Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown, P. 110221 - 110221
Published: Nov. 1, 2024
Language: Английский
Cell Reports, Journal Year: 2024, Volume and Issue: 43(12), P. 115064 - 115064
Published: Dec. 1, 2024
The metabolic reprogramming of tumor cells is a crucial strategy for their survival and proliferation, involving tissue- condition-dependent remodeling certain pathways. While it has become increasingly clear that integrate extracellular intracellular signals to adapt proliferate, nutrient metabolite sensing also exert direct or indirect influences, although the underlying mechanisms remain incompletely understood. Furthermore, changes not only support rapid growth dissemination but promote immune evasion by metabolically "educating" in microenvironment (TME). Recent studies have highlighted profound impact on TME potential targeting pathways as therapeutic strategy, with several enzyme inhibitors showing promising results clinical trials. Thus, understanding how alter remodel proliferation may offer new strategies therapy immunotherapy.
Language: Английский
Citations
9
Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116810 - 116810
Published: Feb. 1, 2025
Language: Английский
Citations
1
Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Elevated lipid metabolism is one of hallmarks malignant tumors. Lipids not only serve as essential structural components biological membranes but also provide energy and substrates for the proliferation cancer cells tumor growth. Cancer meet their needs by coordinating processes absorption, synthesis, transport, storage, catabolism. As research in this area continues to deepen, numerous new discoveries have emerged, making it crucial scientists stay informed about developments metabolism. In review, we first discuss relevant concepts theories or assumptions that help us understand -based therapies. We then systematically summarize latest advancements including mechanisms, novel targets, up-to-date pre-clinical clinical investigations anti-cancer treatment with targeted drugs. Finally, emphasize emerging directions therapeutic strategies, future prospective challenges. This review aims insights guidance field
Language: Английский
Citations
6
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Conjugated linoleic acid (CLA) is known for antiobesity. However, the role of CLA in regulating high-fat diet (HFD)-impaired pubertal mammary gland development remains undefined. Here, female mice and HC11 cells were treated with HFD or palmitic (PA), supplemented without CLA, respectively. We found that prevented impaired exposed to HFD. In vitro, c9, t11-CLA, but not t10, c12-CLA, promoted PA-suppressed proliferation, accompanied by hindered CD36 palmitoylation localization on plasma membrane. Moreover, t11-CLA reduced formation CD36/Fyn/Lyn complex inhibited JNK pathway while activated ERK PA-treated HC11. mechanism, activation inhibition abolished t11-CLA-stimulated proliferation vivo verification, total cell membrane palmitoylation, suppressed CD36/FYN/LYN complex, HFD-fed mice. conclusion, mitigated HFD-impaired via downstream JNK–ERK pathway. These data suggested potential application ameliorating obesity-impaired development.
Language: Английский
Citations
0
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: March 3, 2025
Aberrant lipid metabolism is a well-recognized hallmark of cancer. Notably, breast cancer (BC) arises from lipid-rich microenvironment and depends significantly on metabolic reprogramming to fulfill its developmental requirements. In this review, we revisit the pivotal role in BC, underscoring impact progression tumor microenvironment. Firstly, delineate overall landscape highlighting roles patient prognosis. Given that lipids can also act as signaling molecules, next describe exchanges between BC cells other cellular components Additionally, summarize therapeutic potential targeting aspects processes, lipid-related transcription factors immunotherapy BC. Finally, discuss possibilities problems associated with clinical applications lipid‑targeted therapy propose new research directions advances spatiotemporal multi-omics.
Language: Английский
Citations
0
Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103693 - 103693
Published: May 1, 2025
Language: Английский
Citations
0
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Dec. 19, 2024
Oral squamous cell carcinoma (OSCC) is a prevalent oral malignancy, which poses significant health risks with high mortality rate. Regulatory T cells (Tregs), characterized by their immunosuppressive capabilities, are intricately linked to OSCC progression and patient outcomes. The metabolic reprogramming of Tregs within the tumor microenvironment (TME) underpins function, key pathways such as tryptophan-kynurenine-aryl hydrocarbon receptor, PI3K-Akt-mTOR nucleotide metabolism significantly contributing suppressive activities. Targeting these offers novel therapeutic approach reduce Treg-mediated immunosuppression enhance anti-tumor responses. This review explores dependencies that sustain Treg function in OSCC, highlighting adaptations glycolysis, fatty acid oxidation, amino signaling pathway enable thrive challenging conditions TME. Additionally, discusses influence microbiome on evaluates potential strategies targeting pathways. Despite promising interventions, challenges selectivity, toxicity, heterogeneity, resistance mechanisms remain. concludes perspectives personalized medicine integrative approaches, emphasizing need for continued research translate findings into effective clinical applications treatment.
Language: Английский
Citations
3
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 18, 2024
Lung cancer has posed a significant challenge to global health, and related study been hot topic in oncology. This article focuses on metabolic reprogramming of lung cells, process adapt energy demands biosynthetic needs, supporting the proliferation development tumor cells. In this study, latest studies metabolism were reviewed, including impact products enzymes occurrence cancer, as well progress field treatment targeting relevant pathways. provides some promising potential directions into exploring helps researchers better understand cancer.
Language: Английский
Citations
3
Process Safety and Environmental Protection, Journal Year: 2024, Volume and Issue: 190, P. 63 - 72
Published: Aug. 8, 2024
Language: Английский
Citations
2
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134662 - 134662
Published: Aug. 13, 2024
Language: Английский
Citations
1