The curvilinear relationship between hepatic steatosis index and depression: Findings from the NHANES

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 375, P. 35 - 43

Published: Jan. 19, 2025

Language: Английский

Metabolic Dysfunction‐Associated Steatotic Liver Disease Is Associated With Accelerated Brain Ageing: A Population‐Based Study

Liver International, Journal Year: 2025, Volume and Issue: 45(6)

Published: April 29, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to cognitive decline and dementia risk. We aimed investigate the association between MASLD brain ageing explore role of low-grade inflammation. Within UK Biobank, 30 386 chronic neurological disorders-free participants who underwent magnetic resonance imaging (MRI) scans were included. Individuals categorised into no MASLD/related SLD (including subtypes MASLD, with increased alcohol intake [MetALD] other combined aetiology). Brain age was estimated using machine learning by 1079 MRI phenotypes. gap (BAG) calculated as difference chronological age. Low-grade inflammation (INFLA) based on white blood cell count, platelet, neutrophil granulocyte lymphocyte ratio C-reactive protein. Data analysed linear regression structural equation models. At baseline, 7360 (24.2%) had SLD. Compared SLD, those significantly larger BAG (β = 0.86, 95% CI 0.70, 1.02), well 0.59, 0.41, 0.77) or MetALD 1.57, 1.31, 1.83). The significant across middle-aged (< 60) older (≥ adults, males females, APOE ɛ4 carriers non-carriers. INFLA mediated 13.53% (p < 0.001). MetALD, associated accelerated ageing, even among adults systemic may partially mediate this association.

Language: Английский

Possible link between steatotic liver diseases, severe COVID-19 and cognitive impairment in post-COVID-19 syndrome

Infection, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Purpose Steatotic liver diseases (SLD) have become more prevalent over the last decade and are associated not only with cardiometabolic but also psychological symptoms (depression, fatigue). These common in post-COVID syndrome (PCS). Therefore, aim of study was to analyze burden SLD PCS patients. Methods We systematically screened all patients from our outpatient clinic using transient elastography, structured questionnaires for neurocognitive evaluation blood sample analysis. Controls without known were recruited assessed same approach. Results 560 103 healthy controls included. The overall prevalence high both cohorts (57 vs. 53%). frequently male (41 24%), older (52 44 years) had (87.0 46.4%). Cognitive impairment related than no-SLD group (OR: 1.68, CI: 1.14–2.46, p = 0.008). presence severe COVID-19 hospitalization 2.91, 1.85–4.56, < 0.001). Within 1 year follow-up, 152 289 described a resolution irrespective or absence (log-rank 0.96). Conclusions is cognitive dysfunction PCS. Longitudinal studies needed assess role hepatic steatosis, development post-acute infection regulation (e.g., SARS-CoV-2) differentiate between SLD-associated

Language: Английский