Deciphering the Gut–Liver Axis: A Comprehensive Scientific Review of Non-Alcoholic Fatty Liver Disease DOI Creative Commons
Samradhi Singh, Mona Kriti, Roberto Catanzaro

et al.

Livers, Journal Year: 2024, Volume and Issue: 4(3), P. 435 - 454

Published: Sept. 12, 2024

Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant global health issue. The condition is closely linked to metabolic dysfunctions such obesity and type 2 diabetes. gut–liver axis, bidirectional communication pathway between the gut, plays crucial role in pathogenesis of NAFLD. This review delves into mechanisms underlying exploring influence gut microbiota, intestinal permeability, inflammatory pathways. also explores potential therapeutic strategies centered on modulating microbiota fecal transplantation; phage therapy; use specific probiotics, prebiotics, postbiotics managing By understanding these interactions, we can better comprehend development advancement NAFLD identify targets.

Language: Английский

Utilizing machine learning to analyze trunk movement patterns in women with postpartum low back pain DOI Creative Commons
Doaa A. Abdel Hady, Tarek Abd El‐Hafeez

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 12, 2024

Abstract This paper presents an analysis of trunk movement in women with postnatal low back pain using machine learning techniques. The study aims to identify the most important features related and develop accurate models for predicting pain. Machine approaches showed promise analyzing biomechanical factors (LBP). applied regression classification algorithms proposed dataset from 100 postpartum women, 50 LBP without. Optimized optuna Regressor achieved best performance a mean squared error (MSE) 0.000273, absolute (MAE) 0.0039, R2 score 0.9968. In classification, Basic CNN Random Forest Classifier both attained near-perfect accuracy 1.0, area under receiver operating characteristic curve (AUC) precision recall F1-score outperforming other models. Key predictive included (correlation -0.732 flexion range motion), motion measures (flexion extension correlation 0.662), average movements 0.957 flexion). Feature selection consistently identified pain, flexion, extension, lateral as influential across methods. While limited this initial constrained by generalizability, offered quantitative insight. Models accurately regressed (MSE < 0.01, > 0.95) classified (accuracy 0.94) biomechanics distinguishing LBP. Incorporating additional demographic, clinical, patient-reported may enhance individualized risk prediction treatment personalization. preliminary application advanced analytics supported learning's potential utility determination outcome improvement. provides valuable insights into use techniques can potentially inform development more effective treatments. Trial registration : trial was designed observational cross-section study. approved Ethical Committee Deraya University, Faculty Pharmacy, (No: 10/2023). According ethical standards Declaration Helsinki. complies principles human research. Each patient signed written consent form after being given thorough description trial. conducted at outpatient clinic February 2023 till June 30, 2023.

Language: Английский

Citations

10
Exploring Inflammatory Changes in the Peripheral Blood of Type 2 Diabetes Mellitus in China DOI Creative Commons
Dan Li, Zhiru Zhang, Wen Li

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1679 - 1688

Published: Feb. 1, 2025

Objective: Type 2 diabetes mellitus (T2DM) is a serious, chronic metabolic disease globally and its pathogenesis not completely understood yet. This study aimed to thoroughly investigate the fluctuation of inflammatory markers in peripheral blood patients with T2DM, which are rarely reported. Methods: Peripheral samples from T2DM healthy individuals, as well their clinical information, were collected at Second Affiliated Hospital Soochow University. Flow cytometry was used analyse immune cells cytokines blood. CCK-8 assay performed detect viability THP-1 cell after treatment 5 m&Mgr; or 50 glucose. cytometry, Western Blotting qPCR apoptosis monocytes cells. Results: The numbers white cells, lymphocytes, neutrophils substantially increased elevated IL-6 levels. There significant decrease due caused by sustained high glucose stimulation. Hyperglycemia reduced monocyte altered subgroups increasing number intermediate non-classical monocytes. Conclusion: In summary, our work reveals that do have variations inflammation biomarkers, especially Keywords: mellitus, inflammation,

Language: Английский

Citations

0
Exploring the Antidiabetic Potential of Salvia officinalis Using Network Pharmacology, Molecular Docking and ADME/Drug-Likeness Predictions DOI Creative Commons
Chimaobi James Ononamadu, Véronique Seidel

Plants, Journal Year: 2024, Volume and Issue: 13(20), P. 2892 - 2892

Published: Oct. 16, 2024

A combination of network pharmacology, molecular docking and ADME/drug-likeness predictions was employed to explore the potential

Language: Английский

Citations

2
Deciphering the Gut–Liver Axis: A Comprehensive Scientific Review of Non-Alcoholic Fatty Liver Disease DOI Creative Commons
Samradhi Singh, Mona Kriti, Roberto Catanzaro

et al.

Livers, Journal Year: 2024, Volume and Issue: 4(3), P. 435 - 454

Published: Sept. 12, 2024

Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant global health issue. The condition is closely linked to metabolic dysfunctions such obesity and type 2 diabetes. gut–liver axis, bidirectional communication pathway between the gut, plays crucial role in pathogenesis of NAFLD. This review delves into mechanisms underlying exploring influence gut microbiota, intestinal permeability, inflammatory pathways. also explores potential therapeutic strategies centered on modulating microbiota fecal transplantation; phage therapy; use specific probiotics, prebiotics, postbiotics managing By understanding these interactions, we can better comprehend development advancement NAFLD identify targets.

Language: Английский

Citations

0