BMB Reports,
Journal Year:
2023,
Volume and Issue:
56(9), P. 469 - 481
Published: Aug. 14, 2023
The
gut
microbiome
is
widely
recognized
as
a
dynamic
organ
with
profound
influence
on
human
physiology
and
pathology.Extensive
epidemiological
longitudinal
cohort
studies
have
provided
compelling
evidence
that
disruptions
in
the
early-life
can
long-lasting
health
implications.Various
factors
before,
during,
after
birth
contribute
to
shaping
composition
function
of
neonatal
infant
microbiome.While
these
alterations
be
partially
restored
over
time,
metabolic
phenotypes
may
persist,
necessitating
research
identify
critical
period
for
early
intervention
achieve
phenotypic
recovery
beyond
composition.In
this
review,
we
provide
current
understanding
changes
microbiota
throughout
life
various
affecting
changes.Specifically,
highlight
impact
disruption
development
diseases
later
discuss
perspectives
efforts
recover
from
such
disruptions.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(3), P. 490 - 490
Published: Feb. 22, 2024
In
recent
years,
the
number
of
scientific
publications
on
role
intestinal
microbiota
in
shaping
human
health,
as
well
occurrence
dysbiosis
various
disease
entities,
has
increased
dynamically.
However,
there
is
a
gap
comprehensively
understanding
factors
influencing
child’s
gut
microbiota.
This
review
discusses
establishment
and
immunological
mechanisms
regulating
children’s
microbiota,
emphasising
importance
prioritising
development
appropriate
child
from
planning
stages
pregnancy.
The
databases
PubMed,
Web
Sciences,
Cochrane,
Scopus
Google
Scholar
were
searched
to
identify
relevant
articles.
A
composition
influenced
by
numerous
factors,
such
diet
during
pregnancy,
antibiotic
therapy,
mother’s
vaginal
delivery
method,
and,
later,
feeding
method
environmental
factors.
During
foetus
naturally
acquires
bacterial
strains
mother
through
placenta,
thereby
newborn’s
immune
system.
Inappropriate
maternal
may
increase
risk
preterm
birth.
Formula-fed
infants
typically
exhibit
more
diverse
than
their
breastfed
counterparts.
These
among
others,
shape
maturation
system,
impacting
production
IgA
antibodies
that
are
central
cellular
humoral
defence.
Further
research
should
focus
identifying
specific
microbiota–immune
system
interactions
health
developing
personalised
treatment
strategies
for
immune-related
disorders.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(12), P. 9994 - 9994
Published: June 10, 2023
Sialic
acids
(SAs)
are
α-keto-acid
sugars
with
a
nine-carbon
backbone
present
at
the
non-reducing
end
of
human
milk
oligosaccharides
and
glycan
moiety
glycoconjugates.
SAs
displayed
on
cell
surfaces
participate
in
regulation
many
physiologically
important
cellular
molecular
processes,
including
signaling
adhesion.
Additionally,
sialyl-oligosaccharides
from
act
as
prebiotics
colon
by
promoting
settling
proliferation
specific
bacteria
SA
metabolism
capabilities.
Sialidases
glycosyl
hydrolases
that
release
α-2,3-,
α-2,6-
α-2,8-glycosidic
linkages
terminal
residues
oligosaccharides,
glycoproteins
glycolipids.
The
research
sialidases
has
been
traditionally
focused
pathogenic
microorganisms,
where
these
enzymes
considered
virulence
factors.
There
is
now
growing
interest
commensal
probiotic
their
potential
transglycosylation
activity
for
production
functional
mimics
to
complement
infant
formulas.
This
review
provides
an
overview
exo-alpha-sialidases
gastrointestinal
tract
some
insights
into
biological
role
biotechnological
applications.
Current Oral Health Reports,
Journal Year:
2024,
Volume and Issue:
11(1), P. 15 - 22
Published: Feb. 2, 2024
Abstract
Purpose
of
Review
Individuals
with
Down
syndrome
(DS)
may
be
more
susceptible
to
oral
disorders
as
a
result
combination
genetic
factors,
immunological
disturbances,
anatomical
anomalies,
and
probable
difficulties
in
maintaining
adequate
hygiene.
Within
this
context,
we
provide
comprehensive
review
the
most
important
relationships
between
health
syndrome.
Recent
Findings
investigations
suggest
that
diminished
diversity
microbiome
could
emerge
critical
factor
affecting
individuals
DS.
Plausible
metabolic
peculiarities
inherent
DS,
including
alterations
salivary
characteristics,
presence
obstructive
sleep
apnea,
elevated
end
glycation
product
levels,
hypothyroidism,
exert
significant
influence
on
composition
dynamics
microbiome.
A
analysis
evidence
implies
reduced
occurrence
caries
Furthermore,
recent
meta-analysis
indicates
gingivitis
(OR
1.93;
95%
CI
1.09–3.41)
periodontitis
3.93;
1.81–8.53)
are
frequent
people
DS
strongly
associated.
Oral
function
is
also
affected
resulting
speech,
breathing
eating
problems.
These
findings
underscore
necessity
implement
targeted
educational
awareness
programs,
along
specific
intervention
protocols,
for
younger
generations
their
families,
caregivers.
Summary
Although
trisomy
21
itself
does
not
determine
cause
diseases
common
conditions
such
gingivitis,
periodontitis,
remain
matter
concern.
The
nexus
insufficient
plaque
control,
distinctive
reluctance
engage
treatment
persists
noteworthy
determinants.
professionals
exercise
patience
commitment
when
addressing
care
crucial.
BMB Reports,
Journal Year:
2023,
Volume and Issue:
56(9), P. 469 - 481
Published: Aug. 14, 2023
The
gut
microbiome
is
widely
recognized
as
a
dynamic
organ
with
profound
influence
on
human
physiology
and
pathology.Extensive
epidemiological
longitudinal
cohort
studies
have
provided
compelling
evidence
that
disruptions
in
the
early-life
can
long-lasting
health
implications.Various
factors
before,
during,
after
birth
contribute
to
shaping
composition
function
of
neonatal
infant
microbiome.While
these
alterations
be
partially
restored
over
time,
metabolic
phenotypes
may
persist,
necessitating
research
identify
critical
period
for
early
intervention
achieve
phenotypic
recovery
beyond
composition.In
this
review,
we
provide
current
understanding
changes
microbiota
throughout
life
various
affecting
changes.Specifically,
highlight
impact
disruption
development
diseases
later
discuss
perspectives
efforts
recover
from
such
disruptions.
