Neuroepidemiology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 23
Published: March 26, 2024
<b><i>Background:</i></b>
The
gut
microbiota
(GM)
of
the
human
body
comprises
several
species
microorganisms.
This
microorganism
plays
a
significant
role
in
physiological
and
pathophysiological
processes
various
diseases.
<b><i>Methods:</i></b>
literature
review
includes
studies
that
describe
causative
factors
influence
GM.
GM
is
sensitive
to
like
circadian
rhythms,
environmental
agents,
physical
activity,
nutrition,
hygiene
together
impact
functioning
composition
microbiome.
affects
health
host,
including
psycho-neural
aspects,
due
interconnectivity
between
brain
gut.
Hence,
this
paper
examines
relationship
with
neurodegenerative
disorders
context
these
aforesaid
factors.
<b><i>Conclusion:</i></b>
Future
identify
regulatory
pathways
associated
microbes
can
provide
causal
link
degeneration
at
molecular
level.
Together,
could
be
helpful
designing
preventive
treatment
strategies
aimed
GM,
so
diseases
treated.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: March 7, 2025
The
gut
microbiota
is
the
collective
term
for
microorganisms
that
reside
in
human
gut.
In
recent
years,
advances
sequencing
technology
and
bioinformatics
gradually
revealed
role
of
health.
Dramatic
changes
occur
during
pregnancy
due
to
hormonal
dietary
changes,
these
have
been
associated
with
certain
gestational
diseases
such
as
preeclampsia
(PE)
diabetes
mellitus
(GDM).
Modulation
has
also
proposed
a
potential
treatment
diseases.
present
article
aims
review
current
reports
on
association
between
diseases,
explore
possible
mechanisms,
discuss
probiotics
Uncovering
link
could
lead
new
therapeutic
approach.
Annals of Medicine,
Journal Year:
2025,
Volume and Issue:
57(1)
Published: March 17, 2025
Background/Introduction
Antimicrobial
resistance
(AMR)
and
the
evolution
of
multiple
drug-resistant
(MDR)
bacteria
is
grave
public
health
concern.
To
combat
pandemic
AMR,
it
necessary
to
focus
on
novel
alternatives
for
drug
development.
Within
host,
interaction
pathogen
with
microbiome
plays
a
pivotal
role
in
determining
outcome
pathogenesis.
Therefore,
microbiome-pathogen
one
potential
targets
be
explored
antimicrobials.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 7, 2025
Abstract
The
gut
microbiome
undergoes
substantial
modifications
during
pregnancy,
yet
its
postpartum
adaptations
remain
poorly
understood,
particularly
with
respect
to
the
influence
of
parity.
Here,
we
investigated
impact
childbirth
history
on
maternal
composition
and
function
one
month
postpartum.
By
conducting
metagenomic
sequencing
analysis
60
participants
(34
mothers
26
controls),
demonstrated
significant
differences
in
microbial
diversity
community
structure
between
control,
as
well
subtle
first-time
multiple-birth
mothers.
We
identified
parity-specific
signatures,
showing
enrichment
Dysosmobacter
welbionis,
Candidatus
Saccharibacteria,
Anaerotruncus
species.
Functional
revealed
distinct
metabolic
reprogramming
patterns,
including
increased
amino
acid
biosynthesis
modified
fermentation
pathways
supporting
recovery.
observed
correlations
specific
bacterial
taxa
pathways,
energy
metabolism
immune
modulation.
Notably,
enhanced
capacity
for
short-chain
fatty
production
primiparous
mothers,
mediated
by
AnaerotruncusD.
welbionis,
suggests
a
potential
role
shaping
breast
milk
composition,
which
may
neonatal
development.
These
findings
establish
concept
parity-dependent
programming
provide
insights
into
biological
mechanisms
underlying
adaptation
pregnancy
childbirth.
Discover Immunity.,
Journal Year:
2024,
Volume and Issue:
1(1)
Published: Aug. 20, 2024
Abstract
This
study
is
a
crucial
step
in
understanding
the
dynamics
of
maternal
immune
response
directed
at
paternal
human
leukocyte
antigen
(HLA)
molecules.
HLA
molecules
are
proteins
on
cell
surfaces
that
play
critical
role
system
regulation.
Our
findings
focus
pivotal
antibodies
targeting
fetal
inhibiting
antigen-induced
activation
uterine
cells,
which
essential
for
successful
pregnancies.
Antibodies
produced
by
recognize
and
neutralize
foreign
substances.
The
primary
to
unravel
anti-fetal
rejection
drawing
parallels
transplant
emphasizing
allorecognition—the
process
an
individual’s
recognizes
responds
antigens
from
another
individual
same
species—in
both
cellular
(involving
cells)
humoral
antibodies)
refusal.
Although
exploring
anti-HLA
preventing
loss
patients
with
recurrent
spontaneous
abortion
captivating,
there
still
significant
knowledge
gaps
need
be
addressed.
Further
studies
imperative
reveal
precise
mechanism
these
generate
prevent
responses,
determinants
pregnancy
outcomes.
It
vital
investigate
specificity
whether
they
exclusively
target
specific
trophoblasts
(cells
forming
outer
layer
blastocyst,
providing
nutrients
embryo).
review
paper
not
only
offers
insights
into
development
protective
but
also
lays
foundation
future
research
therapeutic
implications,
particularly
cases
abortion.
Obesity Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 17, 2024
Fathers
remain
under-represented
in
early
childhood
obesity
prevention
research
and
interventions,
despite
growing
evidence
that
paternal
biopsychosocial
factors
behaviors
from
pre-
post-conception
can
influence
lifelong
offspring
health.
Informed
by
a
literature
review
of
high-quality
evidence,
"CO-Parent"
(childhood
obesity-Parent)
is
new
conceptual
model
underpinned
couple
interdependence
theory
socioecological
framework.
Literature
was
searched
for
the
concepts
parental
AND
weight-related
child
weight
or
behaviors,
databases
including
MEDLINE,
PsycINFO,
Global
Health,
Scopus,
SocINDEX.
Prior
syntheses
were
prioritized
as
source
data
to
inform
development.
illustrates
interdependent
independent
effects
maternal
weight,
well-being,
across
preconception,
pregnancy,
postpartum,
years
on
up
age
five.
The
influences
public
policy,
social,
environmental,
economic,
community,
other
complex
modifiable
mediating
are
included
model.
paves
way
paradigm
shift
recognizing
fathers
key
figures
initiatives,
encouraging
them
"share
motherload."
It
highlights
both
roles
play
epidemiology
starting
preconception.
CO-Parent
also
provides
foundations
necessary
guide
future
be
more
inclusive
further
understanding
parents
prevention.
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(8)
Published: Aug. 8, 2024
Abstract
Adverse
intrauterine
conditions
may
cause
fetal
growth
restriction
(FGR),
a
pregnancy
complication
frequently
linked
to
perinatal
morbidity
and
mortality.
Although
many
studies
have
focused
on
FGR,
the
pathophysiological
processes
underlying
this
disorder
are
complex
incompletely
understood.
We
recently
determined
that
galectin-3
(gal-3),
β-galactoside-binding
protein,
regulates
pregnancy-associated
processes,
including
uterine
receptibility,
maternal
vascular
adaptation
placentation.
Because
gal-3
is
expressed
at
both
sides
of
maternal-fetal
interface,
we
unraveled
contribution
maternal-
paternal-derived
fetal-placental
development
in
prenatal
window
its
effects
post-natal
period.
Deficiency
induced
gut
microbiome
dysbiosis,
resulting
sex-specific
mainly
observed
female
fetuses
offspring.
In
addition,
poor
placental
metabolic
adaptions
(characterized
by
decreased
trophoblast
glycogen
content
insulin-like
factor
2
(
Igf2
)
gene
hypomethylation)
were
only
associated
with
lack
maternal-derived
gal-3.
Paternal
deficiency
caused
compromised
vascularization
labyrinth
without
affecting
trajectory.
Thus,
play
key
role
through
gut-placenta
axis.
