Biogenic Nickel Oxide Nanoparticles: Synthesis, Characterization and Biomedical Potential

Molecular Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

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Synthesis of Nano-Selenium from Bombyx batryticatus Polypeptide and Exploring Its Antioxidant and Skin Whitening Ability

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1153 - 1153

Published: March 4, 2025

To increase the stability of selenium in nano state and further improve its antioxidant skin whitening ability, Bombyx batryticatus polypeptide (BBPP) was prepared. The optimum synthesis conditions nano-selenium (BBPP-SeNPs) were determined by a double-peak method. BBPP-SeNPs characterized transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), particle size analysis (PSS). 1,1-Diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS), superoxide anion free radical scavenging rate, total capacity BBPP, vitamin C (VC), measured for comparison. inhibitory ability BBPP on tyrosinase measured. Using mouse modeling, VC results showed that optimal obtained when concentration 0.16 mg/mL, sodium selenite 0.01 mol/L, ultrasound carried out 30 min, ascorbic added 0.04 stirring temperature 20 °C 4 h. has significantly improved. It can be observed obvious skin-reactive oxygen species through Reactive Oxygen Species (ROS) staining section. Through Hematoxylin-Eosin (H&E) staining, it proven high security threshold.

Language: Английский

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Bio-efficacy of Polyethylene Glycol-coated Selenium Nanocomposite Synthesised using Cocos nucifera Haustorium against HepG2 Cell Line

International Research Journal of Multidisciplinary Technovation, Journal Year: 2025, Volume and Issue: unknown, P. 165 - 183

Published: March 30, 2025

The selenium-based nanoparticles (SeNP) are prepared by the amalgamation of Cocos nucifera haustorium (CNH) with sodium selenite. Further conjugating synthesised CNH-SeNP polyethylene glycol (PEG) to design haustorium-based selenium nanocomposite (CNH-SeNC). work involves characterising and studying their bio-potency. Maximum absorption in UV-visible spectrum was at 315 nm 305 for CNH-SeNC. FT-IR affirms involvement functional groups fabrication CHH-SeNP SEM result conveys spherical structure elongated oval shape EDX analysed elemental proportion X-ray diffraction pattern presents amorphous form increased crystallisation CNH-SeNC than that CNH-SeNP. Regarding antimicrobial activity, not much significant effect is seen. comprised excellent antioxidant activity inferred DPPH, ABTS, H2O2 assays highest inhibition percentage 84.67 ± 0.88 % 86.24 1.00 through ABTS 50 µg/mL. Egg albumin denaturation HRBC showed potent anti-inflammatory properties. In HRBC, inflammation equal diclofenac (positive control) 88.30 0.66 %, followed (87.77 0.87 %) (86.13 0.83 %). Biocompatibility brine shrimp lethality assay revealed no toxicity seen low concentrations (10 µg/mL). Initially, mild 48 h higher dosages (20 µg/mL) viability 93.33±5.77% 96.67±5.77% anticancer exhibited tremendous control growth against HepG2 cells without affecting normal IC50 values 31.11 µg/mL 24.41 µg/mL, respectively. Therefore, study's outcome advantages green synthesis from its conjugation PEG providing efficient pharmacological applications.

Language: Английский

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An Alternative Synergistic Strategy to Combat Wound Pathogens with the Antimicrobial and Antioxidant-Rich Herbal Plant Blend

Published: Jan. 1, 2025

Language: Английский

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