Anti-inflammatory activity of essential oil from medicinal plants: An insight into molecular mechanism, in-silico studies and signaling pathways

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156364 - 156364

Published: Jan. 2, 2025

Language: Английский

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Bioactive Compounds and Probiotics Mitigate Mastitis by Targeting NF-κB Signaling Pathway

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 1011 - 1011

Published: Aug. 15, 2024

Mastitis is a significant inflammatory condition of the mammary gland in dairy cows. It caused by bacterial infections and leads to substantial economic losses worldwide. The disease can be either clinical or sub-clinical presents challenges such as reduced milk yield, increased treatment costs, need cull affected pathogenic mechanisms mastitis involve activation Toll-like receptors (TLRs), specifically TLR2 TLR4. These play crucial roles recognizing pathogen-associated molecular patterns (PAMPs) initiating immune responses through NF-κB signaling pathway. Recent vitro studies have emphasized importance TLR2/TLR4/NF-κB pathway development mastitis, suggesting its potential therapeutic target. This review summarizes recent research on role mastitis. focuses how TLRs production proinflammatory cytokines, which, turn, exacerbate response activating tissues. Additionally, discusses various bioactive compounds probiotics that been identified agents for preventing treating targeting Overall, this highlights significance develop effective strategies against which enhance cow health reduce industry.

Language: Английский

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Investigating the Cytoprotective Effect of Syzygium aromaticum and Elettaria cardamomum in Arsenic‐Induced Toxicity in the HCT‐116 Cell Model: A Luminesce‐Based Study

Luminescence, Journal Year: 2025, Volume and Issue: 40(3)

Published: March 1, 2025

Arsenic is a highly menacing environmental pollutant that substantially affects the quality of life, even in traces. It develops various diseases through increasing intracellular ROS interacts with vital organs. Chelation therapy currently recommended for arsenic toxicity. However, these treatment options are not specific and only target symptoms. Besides, they also show toxic effects irreversibly damage crucial Hence, there an urgent need potential safer therapeutic strategy can prevent Therefore, this study, we have investigated SA EC individually combination against toxicity HCT-116 cells. The results obtained from experiments revealed both plant materials comparably inhibited arsenic-induced cellular by antioxidant function. Conversely, combining plants showed better cytoprotection FT-IR HPLC analysis active fractions presence polyphenol compounds (ferulic acid gallic acid) responsible pharmacological effect. This finding unique because no cytoprotective impact has been reported yet on combination.

Language: Английский

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Angelica sinensis Polysaccharide Alleviates Staphylococcus aureus-Induced Mastitis by Regulating The Intestinal Flora and Gut Metabolites

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

The modulation of intestinal flora by various polysaccharides has been shown to mitigate disease progression. Recent research reveals a significant link between and the progression mastitis. This study demonstrates that oral administration

Language: Английский

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Integrating A Role of Injectable Hydrogel for Localized Cancer Therapy

International Journal of Advanced Research in Science Communication and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 425 - 438

Published: Jan. 7, 2025

Traditional intravenous chemotherapy is often associated with adverse effects in normal cells and tissues including liver or kidney dysfunction neurotoxicity, myelosupression. As an alternative approach Localized can minimise the toxicity side effects. method, injectable hydrogel effectively reduce this type of by releasing drugs topically at tumor site . Based on different types stages Cancer a number Hydrogel based drug delivery have been developed that thermo sensitive ,pH sensitive, photo dual hydrogel. The recent advancement hydrogels related discovery mostly for localised cancer therapy used more than traditional chemotherapy. This briefly discussed article.

Language: Английский

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A Comprehensive Guide to Hydrogel-Based Controlled Drug Delivery for Cancer Treatment

Journal of Drug Delivery and Therapeutics, Journal Year: 2024, Volume and Issue: 14(8), P. 195 - 200

Published: Aug. 15, 2024

Common kinds of chemotherapy may cause harm to normal cells and tissues. Localised chemotherapy, unlike systemic can lessen side effects by providing a consistent supply chemotherapeutic chemicals directly the tumour location. This emphasises importance controlled-release biodegradable hydrogels as drug delivery systems. study looks at employing methods for HCC, including thermosensitive, pH-sensitive, photosensitive, dual-sensitive, glutathione-responsive hydrogels. Hydrogel-based systems outperform traditional in cancer treatment. Cancer immunotherapy has emerged new paradigm The development discovery therapeutic molecules increased use clinical studies. article discusses current state functional effective immunotherapy. First, we will discuss fundamental principles benefits implement these mechanisms. Finally, briefly explore existing issues potential applications Keywords: Cancer, controlled system, postoperative radiotherapy, Immunotherapy.

Language: Английский

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Realizing Strength-Controllable and Selective Bactericidal Valorization of Hydrothermal Liquefaction Wastewater from Biowaste by Temperature and Feedstock Regulation

ACS ES&T Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Hydrothermal liquefaction can convert biowaste into biocrude oil, and its wastewater byproduct (HTL-WP) has been confirmed with a wide antimicrobial spectrum. Here, we engineered strength-controllable selective bactericides from HTL-WP via regulation of feedstock operational temperature. Results showed that different feedstocks exhibited significantly inhibition on Escherichia coli Staphylococcus aureus. Increasing temperature varied effects antibacterial strength components. Thereby, HTL temperatures be used as switches to prepare HTL-WPs, showing S. aureus maximum zone 12.08 mm. Meanwhile, conducted interaction analysis characterization, component identification, conversion path reveal the changing mechanism The controllable intensity selectivity was analyzed two aspects: components target strains. This study preliminarily establishes an approach for achieving targeted intensity, which significant reference value environmental-friendly reuse functional (liquid byproduct) in specialized engineering-oriented perspective. It also provides novel utilization prospects valorization treatment solid promote development application technology.

Language: Английский

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Echinacea purpurea and Onopordum acanthium Combined Extracts Cause Immunomodulatory Effects in Lipopolysaccharide-Challenged Rats

Plants, Journal Year: 2024, Volume and Issue: 13(23), P. 3397 - 3397

Published: Dec. 3, 2024

and

Language: Английский

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