Published: Jan. 1, 2025
Language: Английский
Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(2), P. 9 - 9
Published: March 23, 2025
Antibiotic resistance poses a significant global health challenge, undermining the effectiveness of conventional treatments and increasing mortality rates worldwide. Factors such as overuse misuse antibiotics in healthcare agriculture, along with poor infection control practices, have accelerated emergence resistant bacterial strains. The stagnation development new antibiotics, compounded by economic biological challenges, has necessitated alternative approaches to combat infections. Nanotechnology provides promising solution using nanoparticles (NPs), which bacteria through mechanisms like membrane disruption reactive oxygen species (ROS) generation. Metal-based silver zinc oxide possess intrinsic antimicrobial properties, while polymer- carbon-based enhance drug delivery biofilm penetration. Unlike operate multi-mechanistic pathways, reducing likelihood improving treatment efficacy. This review aims provide an updated, in-depth look at recent advances nanoparticle research targeting antibiotic resistance, discussing different types nanoparticles, action, current challenges opportunities. By exploring evolving role nanotechnology addressing this crisis, intends highlight potential for transform landscape infections inspire further into these innovative solutions.
Language: Английский
Citations
2
Microbial Cell Factories, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 7, 2025
Abstract Background Nowadays, researchers are attracted to the phyco-synthesis of selenium nanoparticles (SeNPs) for biotechnological and medical applications as they possess many advantages such safety, nutritional value, easy biodegradation than gold, copper, silver nanoparticles. Spirulina platensis is preferred microalgae SeNPs synthesis because it contains compounds that increase their stability making them fit biomedical treatments. Results The biosynthesized (SP-SeNPs) were spherical crystalline, with a diameter 65 nm net charge -16.7 mV. Furthermore, surrounded by active groups responsible stability. DPPH radical scavenging test assessed antioxidant efficacy SP-SeNPs exposed inhibition 79.234% at 100 µM dosage. ABTS H 2 O assay dose-dependent recording IC50 50.69 116.18 µg/ml, respectively. antibacterial was investigated against 13 G-negative & G-positive bacteria. study demonstrated had antibiofilm efficiencies tested strains MBC 286–333 µg/ml. highest percentages biofilm recorded Bacillus subtilis Klebsiella pneumoniae, ratios 78.8 69.9%, prepared SP-SeNPS efficiently suppressed fungi growth MIC (350 µg/ml) MFCs (480–950 µg/ml). Most notably, biogenic effectively extended clot formation period 170.4 S prothrombin time (PT) 195.6 activated partial thromboplastin (aPTT). reduced cell viability breast adenocarcinoma (MCF-7) ovarian cancer (SKOV-3) lines percentage 17.6009% 14.9484% concentration ug/ml, Moreover, could alleviate inflammation in RAW 264.7 macrophages reduction 8.82% Nitric oxide concentration. Conclusion investigation findings reveal hopeful antimicrobial, anti-tumor, anticoagulant, antioxidant, anti-inflammatory factor can be applied cures.
Language: Английский
Citations
1
Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42739 - e42739
Published: Feb. 1, 2025
This review explores the synergistic potential of natural products and nanotechnology for viral infections, highlighting key antiviral, immunomodulatory, antioxidant properties to combat pandemics caused by highly infectious viruses. These often result in severe public health crises, particularly affecting vulnerable populations due respiratory complications increased mortality rates. A cytokine storm is initiated when an overload pro-inflammatory cytokines chemokines released, leading a systemic inflammatory response. Viral mutations limited availability effective drugs, vaccines, therapies contribute continuous transmission virus. The coronavirus disease-19 (COVID-19) pandemic has sparked renewed interest product-derived antivirals. efficacy traditional medicines against infections examined. Their anti-inflammatory, are highlighted. discusses how enhances herbal combating infections.
Language: Английский
Citations
1
RSC Advances, Journal Year: 2024, Volume and Issue: 14(45), P. 33568 - 33586
Published: Jan. 1, 2024
Antimicrobial mechanism of nanomaterials to combat AMR.
Language: Английский
Citations
7
Published: Jan. 1, 2025
The repair of bone graft defects remains a challenging clinical issue, often accompanied by the risk infection in grafted area. To address this, we have developed novel GO-CS@ZnO composite material specifically designed for defect repair. key innovation this study lies successful synthesis and characterization material, which exhibits excellent antibacterial properties favorable biocompatibility. was synthesized using water bath method characterized XRD, FT-IR, XPS, SEM. material's hydrophilic confirmed through contact angle measurements. Rigorous testing demonstrated its strong properties, while cytotoxicity tests further good These findings highlight significant potential field repair, offering promising new approach to addressing challenge.
Language: Английский
Citations
0
Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 35 - 35
Published: Jan. 4, 2025
In this present study, we developed and characterized a series of supramolecular G4 hydrogels by integrating β-cyclodextrin (β-CD) boronic acid linkers into matrix to enhance antibacterial activity against Staphylococcus aureus (S. aureus). We systematically investigated how varying the number free moieties (ranging from two six), along with guanosine β-CD content, influences both structural integrity antimicrobial efficacy these materials. Comprehensive characterization using FTIR, circular dichroism, X-ray diffraction, SEM, AFM, rheological measurements confirmed successful synthesis revealed that higher content correlated stronger, more organized network. The most effective hydrogel displayed an inhibition zone 25 mm in disk diffusion assays, was further explored as drug delivery platform, aim exploit capacity cavity incorporate hydrophobic drugs. Norfloxacin (Nfx), poorly water-soluble antibiotic, successfully encapsulated within through inclusion complex formation β-CD, improving its solubility enabling sustained, targeted release. Nfx-loaded expanded 49 completely eradicated S. cells 24 h, outperforming unloaded Nfx. These results highlight synergistic effect controlled release, underlining potential versatile platforms for localized therapy, such wound dressings or implant coatings. Nevertheless, vivo studies long-term stability assessments are needed fully establish clinical relevance, safety, scalability before systems can be translated routine healthcare applications.
Language: Английский
Citations
0
Journal of Nanoparticle Research, Journal Year: 2025, Volume and Issue: 27(4)
Published: April 1, 2025
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0