Gelatin Nanoemulsion-Based Co-Delivery of Terbinafine and Essential Oils for Treatment of Candida albicans Biofilms DOI Creative Commons
Muhammad Aamir Hassan, Sàdaf Noor, Jungmi Park

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 127 - 127

Published: Jan. 9, 2025

Fungal infections represent a significant global health challenge. Candida albicans is particularly widespread pathogen, with both molecular and biofilm-based mechanisms making it resistant to or tolerant of available antifungal drugs. This study reports combination therapy, active against C. albicans, utilizing terbinafine essential oils incorporated into gelatin-based nanoemulsion system (T-GNE). Eugenol methyl eugenol/terbinafine T-GNEs had an additive efficacy, while carvacrol (CT-GNE) worked synergistically terbinafine, providing effective treatment minimal mammalian cell toxicity. Confocal microscopy demonstrated that CT-GNE penetrated the dense biofilm disrupted fungal membrane. Overall, in GNE provided promising for biofilms.

Language: Английский

Antimicrobial Efficacy of Eugenol and Neem Oil Nanoemulsions Against Foodborne Pathogens and Food Spoilage Fungi DOI Creative Commons

L Susmita Devi,

Avik Mukherjee, Manash R. Das

et al.

Food Bioengineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

ABSTRACT Essential oils are widely recognized for their antimicrobial properties, making them promising natural alternatives food preservation and spoilage prevention. However, practical challenges such as hydrophobicity, instability, strong aroma have limited applications. To overcome these challenges, this study aimed to prepare nanoemulsions of eugenol neem oil using ultrasonication techniques evaluating efficacy, highlighting potential sustainable preservation. The efficacy was evaluated against four foodborne bacteria fungi well diffusion method. Nanoemulsions, formulated with concentrations 5%–20%, exhibited particle sizes ranging from 135 373 d.nm 410 587 eugenol, polydispersity indices indicating variable size distribution (0.27–0.88 0.13–0.60 eugenol). Stability tests confirmed overall stability, although some eugenol‐based minor precipitation due turbidity. Both displayed significant activity, being more effective even at lower concentrations. NNE‐20 showed the largest inhibition zones Bacillus subtilis (17.83 mm), Escherichia coli (14.83 Enterobacter aerogenes (14.16 while NNE‐15 most Staphylococcus aureus (14 mm). Eugenol superior antibacterial achieving 18–23.5 mm higher For fungi, inhibited Colletotrichum gloeosporioides, Rhizopus stolonifer Aspergillus niger (15–20 outperformed oil, showing 24–26 ( ) 20–24 Saccharomyces cerevisiae ). These findings highlight stable, natural, synthetic preservatives improving safety extending shelf life.

Language: Английский

Citations

0
Essentials oils nanoemulsion as food safety and security: A short review DOI Open Access

K Khairan,

Rinaldi Idroes, Nur Balqis Maulydia

et al.

IOP Conference Series Earth and Environmental Science, Journal Year: 2025, Volume and Issue: 1476(1), P. 012093 - 012093

Published: April 1, 2025

Abstract Essential oil is a concentrated hydrophobic liquid, easily evaporated because they contain many volatile chemical compounds. secondary metabolites produced from plant and nutritionally required by living organism. generally used in the perfume, cosmetics, soap, air fresheners, aromatherapy flavouring food beverages. However, an essential limited water solubility, low stability, high volatility. Therefore, alternative product needed that can overcome these problems, one of which nanoemulsion product. Using integrative review methodology, several scientific articles evaluating safety security assessment essentials oils-nanoemusion (EO-NE) were selected. products have become promising due to advances nanotechnology. This article describes potential nanoemulsions against bacteria fungi, as bio pesticides, protect beverages aspergillus contamination contamination, including increasing shelf life products, bioactive packaging materials also been thoroughly discussed.

Language: Английский

Citations

0
Antifungal resistance in dermatophytes: Essential oil-based nanoformulations as new generation therapeutics against dermatophytes DOI

Arati Yadav,

Kishor Kumar Paul,

Monisha Soni

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107622 - 107622

Published: April 1, 2025

Language: Английский

Citations

0
Therapeutic efficacy of chitosan-based hybrid nanomaterials to treat microbial biofilm and their infections – A review DOI

Salim Anisha,

Palanivel Sathishkumar

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137850 - 137850

Published: Nov. 1, 2024

Language: Английский

Citations

3
Gelatin Nanoemulsion-Based Co-Delivery of Terbinafine and Essential Oils for Treatment of Candida albicans Biofilms DOI Creative Commons
Muhammad Aamir Hassan, Sàdaf Noor, Jungmi Park

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 127 - 127

Published: Jan. 9, 2025

Fungal infections represent a significant global health challenge. Candida albicans is particularly widespread pathogen, with both molecular and biofilm-based mechanisms making it resistant to or tolerant of available antifungal drugs. This study reports combination therapy, active against C. albicans, utilizing terbinafine essential oils incorporated into gelatin-based nanoemulsion system (T-GNE). Eugenol methyl eugenol/terbinafine T-GNEs had an additive efficacy, while carvacrol (CT-GNE) worked synergistically terbinafine, providing effective treatment minimal mammalian cell toxicity. Confocal microscopy demonstrated that CT-GNE penetrated the dense biofilm disrupted fungal membrane. Overall, in GNE provided promising for biofilms.

Language: Английский

Citations

0