Functional Hydrogels Promote Chronic Infectious Wound Healing by Re-rousing Macrophage M1 and Inducing Bacterial Copper-Like Death DOI Creative Commons
Chaoqun Xiang, Chaoyu Pu,

Xuemei Zhong

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Abstract Background: Traditional antibiotics are often ineffective against biofilm-associated infections, and biofilm-induced macrophage immune evasion directly halts the wound healing process. Disrupting biofilms regulating functions critical to improving healing. Results: In this study, we synthesized g-C3N4 with peroxidase (POD) enzyme activity via thermal polymerization copper alginate microspheres (CAM) gas cutting. These were co-encapsulated into GelMA hydrogels form a functionalized repair system (GelMA/CAM@g-C3N4) both anti-biofilm local microenvironment remodeling capabilities. vitro, exhibited excellent biocompatibility promoted endothelial cell migration, vascular formation, CD31 expression. It also polarized macrophages toward M1 phenotype, restoring their pro-inflammatory functions, upregulating inflammatory cytokines (IL-1, IL-6, TNF-α), inhibiting Staphylococcus aureus Escherichia coli. vivo, suppressed S. growth, angiogenesis collagen deposition, reshaped pathological achieve regeneration. Conclusions: This offers new therapeutic strategy for chronic infectious wounds.

Language: Английский

Eco-Friendly Production of Antimicrobial Nanoparticles for Sustainability DOI
Arunima Biswas,

Jibanjyoti Panda,

Amilia Nongbet

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

1
Combating dental biofilms using plant-derived flavonoids: a simple and potential therapeutic approach DOI

Lekha Sree Venkatesan,

Vinothini Gunasekaran,

Palanivel Sathishkumar

et al.

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 2

Published: Oct. 1, 2024

Language: Английский

Citations

4
Functional Hydrogels Promote Chronic Infectious Wound Healing by Re-rousing Macrophage M1 and Inducing Bacterial Copper-Like Death DOI Creative Commons
Chaoqun Xiang, Chaoyu Pu,

Xuemei Zhong

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101571 - 101571

Published: Feb. 14, 2025

Language: Английский

Citations

0
Contribution of Microbial Nanotechnology to Sustainable Development Goals DOI
Bhupendra Pratap Singh, Nitin Chauhan,

Nisha Agrawal

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Phytochemicals: A Promising Strategy to Combat Biofilm-Associated Antimicrobial Resistance DOI Creative Commons
Jiddu Joseph,

Sanya Boby,

Muhammed Shafeekh Muyyarikkandy

et al.

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

The impact of antimicrobial resistance (AMR) on global health and the economy is gradually increasing over time. This issue further exacerbated by biofilms due to their inherent mechanisms that worsen conditions. Furthermore, can limit effectiveness antibiotics hinder changes in physiology gene expression contribute AMR. There are several ways promote development AMR among various biofilm-associated bacteria. These include obstruct antibiotic penetration matrix, role quorum sensing, horizontal transfer genes. It essential prevent bacterial using safer alternatives both control Recently, phytochemicals have gained attention as natural products with antibiotic-potentiating effects. Various studies shown play different roles disturbing biofilms, from affecting extracellular matrix targeting sensing DNA replication. Additionally, challenges such standardizing action could facilitate approval for therapeutic uses, thus helping demonstrate potential use against biofilms.

Language: Английский

Citations

0
Intersection of artificial intelligence, microbes, and bone and joint infections: a new frontier for improving management outcomes DOI Creative Commons
Mohamed A. Imam,

A. Abdel-Rahman,

Adam Zumla

et al.

The Lancet Microbe, Journal Year: 2024, Volume and Issue: unknown, P. 101008 - 101008

Published: Oct. 1, 2024

Language: Английский

Citations

0
Functional Hydrogels Promote Chronic Infectious Wound Healing by Re-rousing Macrophage M1 and Inducing Bacterial Copper-Like Death DOI Creative Commons
Chaoqun Xiang, Chaoyu Pu,

Xuemei Zhong

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Abstract Background: Traditional antibiotics are often ineffective against biofilm-associated infections, and biofilm-induced macrophage immune evasion directly halts the wound healing process. Disrupting biofilms regulating functions critical to improving healing. Results: In this study, we synthesized g-C3N4 with peroxidase (POD) enzyme activity via thermal polymerization copper alginate microspheres (CAM) gas cutting. These were co-encapsulated into GelMA hydrogels form a functionalized repair system (GelMA/CAM@g-C3N4) both anti-biofilm local microenvironment remodeling capabilities. vitro, exhibited excellent biocompatibility promoted endothelial cell migration, vascular formation, CD31 expression. It also polarized macrophages toward M1 phenotype, restoring their pro-inflammatory functions, upregulating inflammatory cytokines (IL-1, IL-6, TNF-α), inhibiting Staphylococcus aureus Escherichia coli. vivo, suppressed S. growth, angiogenesis collagen deposition, reshaped pathological achieve regeneration. Conclusions: This offers new therapeutic strategy for chronic infectious wounds.

Language: Английский

Citations

0