Phenolic Compounds from Pyrus communis Residues: Mechanisms of Antibacterial Action and Therapeutic Applications
Antibiotics,
Journal Year:
2025,
Volume and Issue:
14(3), P. 280 - 280
Published: March 8, 2025
Background/Objectives:
The
food
industry
produces
substantial
amounts
of
fruit
byproducts,
which
are
often
discarded
despite
their
high
content
bioactive
compounds
with
potential
therapeutic
applications.
Pyrus
communis
(pear)
residues,
particularly
rich
in
phenolic
compounds,
represent
a
valuable
yet
underutilized
resource.
These
byproducts
have
demonstrated
significant
antioxidant
and
antibacterial
properties,
suggesting
for
medical
pharmaceutical
This
review
aims
to
provide
comprehensive
analysis
the
profile
P.
emphasizing
mechanisms
prospective
use
combating
oxidative
stress
resistance.
Methods:
A
key
from
residues
was
conducted
using
ScienceDirect
Google
Scholar
databases
(from
2014
2024).
Studies
assessing
activities
were
reviewed,
focus
on
action
against
Gram-positive
Gram-negative
bacterial
pathogens.
Results:
minimum
14
distinct
identified
among
residues.
However,
chlorogenic
acid
catechin
as
primary
contributors
activity
Hydroquinone
exhibited
strong
effects
through
membrane
disruption,
enzyme
inhibition,
metabolic
interference.
Despite
this
potential,
hydroquinone’s
cytotoxicity
regulatory
concerns
limit
its
direct
application.
Conclusions:
While
phenolics
show
promise
natural
agents,
future
research
should
address
bioavailability,
extraction
standardization,
safe
formulation
strategies.
Investigating
synergy
conventional
antibiotics
improving
stability
cosmetic
applications
steps
toward
practical
use.
In
vivo
clinical
studies
crucial
validating
ensuring
approval.
Language: Английский
Disarming Staphylococcus aureus: Review of Strategies Combating This Resilient Pathogen by Targeting Its Virulence
Pathogens,
Journal Year:
2025,
Volume and Issue:
14(4), P. 386 - 386
Published: April 15, 2025
Staphylococcus
aureus
is
a
formidable
pathogen
notorious
for
its
antibiotic
resistance
and
diverse
virulence
mechanisms,
including
toxin
production,
biofilm
formation,
immune
evasion.
This
article
explores
innovative
anti-virulence
strategies
to
disarm
S.
by
targeting
critical
factors
without
exerting
bactericidal
pressure.
Key
approaches
include
inhibiting
adhesion
neutralizing
toxins,
disrupting
quorum
sensing
(e.g.,
Agr
system
inhibitors),
blocking
iron
acquisition
pathways.
Additionally,
interventions
two-component
regulatory
systems
are
highlighted.
While
promising,
challenges
such
as
strain
variability,
resilience,
pharmacokinetic
limitations,
evolution
underscore
the
need
combination
therapies
advanced
formulations.
Integrating
with
traditional
antibiotics
host-directed
offers
sustainable
solution
combat
multidrug-resistant
aureus,
particularly
methicillin-resistant
strains
(MRSA),
mitigate
global
public
health
crisis.
Language: Английский
Synergistic Activity of Vancomycin and Gentamicin Against Staphylococcus aureus Biofilms on Polyurethane Surface
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(5), P. 1119 - 1119
Published: May 13, 2025
Background:
Staphylococcus
aureus
are
frequently
associated
with
biofilm
formation
on
intravascular
devices.
Biofilms
limit
antimicrobial
penetration
and
promote
phenotypic
resistance,
challenging
conventional
treatment
strategies.
Vancomycin
(VAN)
gentamicin
(GEN)
have
been
used
clinically,
but
their
combined
antibiofilm
activity
remains
underexplored.
Objectives:
This
study
evaluates
the
efficacy
of
VAN
GEN,
alone
in
combination,
against
biofilms
formed
by
methicillin-resistant
(MRSA)
methicillin-sensitive
S.
(MSSA)
polyurethane.
Methods:
MICs
were
determined
for
GEN.
Biofilm
biomass
metabolic
quantified
using
crystal
violet
MTT
assays,
respectively.
viability
was
assessed
through
fluorescence
microscopy
a
modified
Calgary
Device.
A
continuous-flow
peristaltic
model
developed
to
test
under
simulated
catheter
conditions.
Results:
While
monotherapy
or
GEN
had
modest
effects,
combination
significantly
reduced
activity.
20
mg/L
+
8
40
achieved
over
70%
reduction
MRSA
complete
eradication
MBEC
assays.
Dynamic
assays
confirmed
therapy.
Conclusion:
The
VAN/GEN
exhibits
synergistic
aureus,
particularly
MRSA.
These
findings
support
its
potential
application
salvage
strategies,
including
antibiotic
lock
Language: Английский