Disarming Staphylococcus aureus: Review of Strategies Combating This Resilient Pathogen by Targeting Its Virulence DOI Creative Commons
Abdelaziz Touati, Nasir A. Ibrahim, Takfarinas Idres

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(4), P. 386 - 386

Published: April 15, 2025

Staphylococcus aureus is a formidable pathogen notorious for its antibiotic resistance and diverse virulence mechanisms, including toxin production, biofilm formation, immune evasion. This article explores innovative anti-virulence strategies to disarm S. by targeting critical factors without exerting bactericidal pressure. Key approaches include inhibiting adhesion neutralizing toxins, disrupting quorum sensing (e.g., Agr system inhibitors), blocking iron acquisition pathways. Additionally, interventions two-component regulatory systems are highlighted. While promising, challenges such as strain variability, resilience, pharmacokinetic limitations, evolution underscore the need combination therapies advanced formulations. Integrating with traditional antibiotics host-directed offers sustainable solution combat multidrug-resistant aureus, particularly methicillin-resistant strains (MRSA), mitigate global public health crisis.

Language: Английский

Disarming Staphylococcus aureus: Review of Strategies Combating This Resilient Pathogen by Targeting Its Virulence DOI Creative Commons
Abdelaziz Touati, Nasir A. Ibrahim, Takfarinas Idres

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(4), P. 386 - 386

Published: April 15, 2025

Staphylococcus aureus is a formidable pathogen notorious for its antibiotic resistance and diverse virulence mechanisms, including toxin production, biofilm formation, immune evasion. This article explores innovative anti-virulence strategies to disarm S. by targeting critical factors without exerting bactericidal pressure. Key approaches include inhibiting adhesion neutralizing toxins, disrupting quorum sensing (e.g., Agr system inhibitors), blocking iron acquisition pathways. Additionally, interventions two-component regulatory systems are highlighted. While promising, challenges such as strain variability, resilience, pharmacokinetic limitations, evolution underscore the need combination therapies advanced formulations. Integrating with traditional antibiotics host-directed offers sustainable solution combat multidrug-resistant aureus, particularly methicillin-resistant strains (MRSA), mitigate global public health crisis.

Language: Английский

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