Hormonal
drugs
in
biological
samples
are
usually
low
concentration
and
highly
intrusive.
It
is
of
great
significance
to
enhance
the
sensitivity
specificity
detection
process
hormone
by
utilizing
appropriate
sample
pretreatment
methods
for
drugs.
In
this
study,
a
method
was
developed
effectively
enrich
estrogens
serum
combining
molecularly
imprinted
solid-phase
extraction,
which
has
high
specificity,
deep
eutectic
solvent-dispersive
liquid-liquid
microextraction,
enrichment
ability.
The
theoretical
basis
effective
solvent
also
computed
simulation.
results
showed
that
combination
extraction
microextraction
could
improve
HPLC
33~125
folds,
at
same
time
reduce
interference.
addition,
relatively
solvation
energy
estrogen
possesses
surface
charge
similar
estrogen,
thus
can
estrogen.
study
provides
ideas
separation
low-concentration
application
extraction.
Hormonal
drugs
in
biological
samples
are
usually
low
concentration
and
highly
intrusive.
It
is
of
great
significance
to
enhance
the
sensitivity
specificity
detection
process
hormone
by
utilizing
appropriate
sample
pretreatment
methods
for
drugs.
In
this
study,
a
method
was
developed
effectively
enrich
estrogens
serum
combining
molecularly
imprinted
solid-phase
extraction,
which
has
high
specificity,
deep
eutectic
solvent-dispersive
liquid-liquid
microextraction,
enrichment
ability.
The
theoretical
basis
effective
solvent
also
computed
simulation.
results
showed
that
combination
extraction
microextraction
could
improve
HPLC
33~125
folds,
at
same
time
reduce
interference.
addition,
relatively
solvation
energy
estrogen
possesses
surface
charge
similar
estrogen,
thus
can
estrogen.
study
provides
ideas
separation
low-concentration
application
extraction.