Paper-Based Aptasensor Assay for Detection of Food Adulterant Sildenafil DOI Creative Commons
Murat Kavruk, Veli Cengiz Özalp

Biosensors, Journal Year: 2024, Volume and Issue: 14(12), P. 620 - 620

Published: Dec. 17, 2024

Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension but often illicitly added energy drinks chocolates. This study introduces a lateral flow strip test using aptamers specific sildenafil for detecting its illegal presence in food. The process involved graphene oxide SELEX identify high-affinity aptamers, which were then converted into molecular gate structures on mesoporous silica nanoparticles, creating unique signaling system. system was integrated chromatography strips tested buffers chocolate samples containing sildenafil. method simplifies the assay (LFA) small molecules provides tool signal amplification. detection limit these found be 68.2 nM (31.8 µg/kg) spiked food samples.

Language: Английский

Analytical quality by design guided white analytical chemistry driven green in the development of LC-ICP-MS method for arsenic speciation analysis in HEK-293 cells DOI
Pothuraju Naresh, Sajal Roy,

Prashant Vilas Pawaskar

et al.

Journal of Chromatography B, Journal Year: 2025, Volume and Issue: 1252, P. 124474 - 124474

Published: Jan. 18, 2025

Language: Английский

Citations

1
Insights into the sustainability of liquid chromatographic methods for favipiravir bioanalysis: a comparative study DOI Creative Commons
Ahmed Mostafa

RSC Advances, Journal Year: 2024, Volume and Issue: 14(28), P. 19658 - 19679

Published: Jan. 1, 2024

The introduction of favipiravir as a broad-spectrum antiviral agent, particularly in treating influenza and exploring its potential against COVID-19, emphasizes the necessity for efficient analytical methods.

Language: Английский

Citations

2
UPLC-MS/MS-Based Target Screening of 90 Phosphodiesterase Type 5 Inhibitors in 5 Dietary Supplements DOI Creative Commons
Shaoming Jin, Yaonan Wang, Ning Xiao

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3601 - 3601

Published: July 30, 2024

The aim of individuals consuming health supplements is to attain a robust state through nutritional regulation. However, some unscrupulous manufacturers, motivated by profit, fraudulently incorporate drugs or unauthorized components with therapeutic effects into the product for instant performance enhancement. long-term use these products may inadvertently inflict harm on human and fail promote nutritive healthcare. illegal inclusion substances prevalent in kidney-tonifying sexuality-enhancing products. Developing effective analytical methods identify screen added ingredients can effectively prevent such from reaching remaining market. A target screening method detection quantification 90 phosphodiesterase type 5 inhibitors (PDE-5is) kinds was developed validated. dietary varied tablets, capsules, protein powder wine beverages. Sample preparation completed one-step liquid phase extraction. process PDE-5is done efficiently within 25 min ultra-high chromatography tandem mass spectrometry (UPLC-MS/MS) using dynamic multiple reaction monitoring (dMRM) technique. LODs were detected at levels ranging 85 ng/g ng/mL. This novel targeting methodology be applied routine market supervision. Among 286 batches samples, 8 found positive. Three first healthy demonstrated herein will promising powerful tool rapid PDE-5is.

Language: Английский

Citations

0
Paper-Based Aptasensor Assay for Detection of Food Adulterant Sildenafil DOI Creative Commons
Murat Kavruk, Veli Cengiz Özalp

Biosensors, Journal Year: 2024, Volume and Issue: 14(12), P. 620 - 620

Published: Dec. 17, 2024

Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension but often illicitly added energy drinks chocolates. This study introduces a lateral flow strip test using aptamers specific sildenafil for detecting its illegal presence in food. The process involved graphene oxide SELEX identify high-affinity aptamers, which were then converted into molecular gate structures on mesoporous silica nanoparticles, creating unique signaling system. system was integrated chromatography strips tested buffers chocolate samples containing sildenafil. method simplifies the assay (LFA) small molecules provides tool signal amplification. detection limit these found be 68.2 nM (31.8 µg/kg) spiked food samples.

Language: Английский

Citations

0