Early Detection and Monitoring of Nephrolithiasis: The Potential of Electrochemical Sensors

Sensors, Journal Year: 2025, Volume and Issue: 25(8), P. 2547 - 2547

Published: April 17, 2025

Nephrolithiasis (kidney stone disease) continues to pose a significant global health challenge, affecting millions of individuals and placing substantial economic pressures on healthcare systems. Traditional diagnostic methods—such as computed tomography (CT), ultrasound, basic urinalysis—are often limited by issues including radiation exposure, lower sensitivity in detecting small stones, operator dependency, the inability provide real-time analysis. In response, electrochemical sensors have emerged innovative powerful tools capable rapid, sensitive, specific detection key biomarkers associated with nephrolithiasis. This review highlights advances approaches for monitoring oxalate uric acid, two primary metabolites implicated kidney formation. We discuss principles electrode design fabrication, nanomaterial integration, 3D printing, molecular imprinting, which markedly improved limits selectivity. Furthermore, we critically evaluate practical challenges—such sensor fouling, reproducibility, stability complex biological matrices—that currently impede widespread clinical implementation. The potentials miniaturization point-of-care integration are emphasized, an eye toward continuous or home-based systems that can offer personalized insights into risk formation progression. By consolidating recent findings exploring future trends multi-analyte wearable diagnostics, this provides roadmap translating from research laboratories routine practice, ultimately aiming enhance early intervention improve patient outcomes

Language: Английский

Laser-Induced Graphene-Based microfluidic electrochemical biosensor for clinical analysis

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113734 - 113734

Published: April 1, 2025

Language: Английский

Trimetallic ZIFs-derived nanoarchitecture for portable wireless electrochemical determination of chlorogenic acid in natural medicine and food samples

Microchemical Journal, Journal Year: 2024, Volume and Issue: 207, P. 111877 - 111877

Published: Oct. 9, 2024

Language: Английский