Therapeutic Frontiers in Nanozyme-Based Cancer Treatment: Advances, Challenges, and Future Directions DOI Open Access

D.M. Silva,

A.I. Kuruppu

Vidyodaya Journal of Science, Journal Year: 2024, Volume and Issue: 27(02)

Published: Dec. 30, 2024

Nanozymes, artificial nanomaterials mimicking enzyme activity, are at the forefront of innovative cancer therapies, particularly in chemodynamic therapy (CDT), photodynamic (PDT), and photothermal (PTT). Their capacity to selectively generate reactive oxygen species under tumor-specific conditions, including low pH high H₂O₂ levels, facilitates targeted induction cell death while minimizing damage healthy tissues. When integrated with PDT or PTT, nanozymes enhance oxidative stress promote immunogenic death, further amplifying anti-tumor immune responses. Recent advances single-atom intelligent have shown promise overcoming therapeutic limitations, such as tumor hypoxia suppression modulating microenvironment boost treatment efficacy. Additionally, ongoing preclinical clinical evaluations highlight potential synergistically immunotherapy outcomes. advantages over traditional enzymes, stability, tunability, cost-effectiveness, ability maintain catalytic activity hostile environments, position transformative agents therapy. However, their translation faces significant challenges, biocompatibility concerns, delivery inefficiencies sites, stringent regulatory hurdles, which require comprehensive research solutions address. Despite these advancements nanozyme design functionalization continue pave way for more effective safer applications will be discussed detail this review.Keywords: Cancer therapy, Nanomaterial, ROS, (PTT)

Language: Английский

3D-Printed Metal Organic Frameworks-Based Supramolecular Hydrogel as Biological Materials DOI Creative Commons
Moses Kumi, Bridget Kpomah, Onome Ejeromedoghene

et al.

Supramolecular Materials, Journal Year: 2025, Volume and Issue: unknown, P. 100100 - 100100

Published: Feb. 1, 2025

Language: Английский

Citations

0
Multifunctional Metal-Organic Frameworks in Breast Cancer Therapy: Advanced Nanovehicles for Effective Treatment DOI
Shefali Shukla, Debasis Bagchi,

Divya divya

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 289, P. 117424 - 117424

Published: Feb. 20, 2025

Language: Английский

Citations

0
Preparation of Starch Biopolymer Decorated Bimetallic Metal-Organic Framework (Mn-Zn) Bio-nanocomposite for pH-Controlled Drug Delivery DOI
Malihe Pooresmaeil,

Rahim Safarpour,

Hassan Namazi

et al.

Journal of Polymers and the Environment, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Encapsulation of NH2-MIL-101(Fe) with dialdehyde starch through Schiff-base imine: A development of a pH-responsive core-shell fluorescent nanocarrier for doxorubicin delivery DOI Creative Commons
Ali Mohammadzadeh, Siamak Javanbakht, Réza Mohammadi

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100794 - 100794

Published: April 1, 2025

Language: Английский

Citations

0
Efficient Photocatalytic Degradation of Rhodamine B With Heterostructured CdS/Mn‐MOF Composite DOI

Huan Zhang,

Jin Wei-bin,

Peng Li

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(5)

Published: April 8, 2025

ABSTRACT A highly efficient photocatalyst, the CdS/Mn‐MOF composite, was synthesized by first preparing a new 2D Mn‐MOF (Mn(L)·H 2 O, H L = 5‐(2‐benzothiazolyl)isophthalic acid) precursor through solvothermal method and subsequently growing CdS nanoparticles. X‐ray diffraction (XRD), scanning electron microscopy (SEM), photoelectron spectroscopy (XPS), UV–vis spectroscopy, other techniques were utilized to characterize structural, morphological, textural, compositional, optical properties of composites. The prepared photocatalysts, designated as X‐CdS/Mn‐MOF (where X 50, 25, 10, represents mass percentage CdS), tested for photocatalytic performance. Among them, 50‐CdS/Mn‐MOF sample exhibits optimized degradation efficiency 99.1% Rhodamine B (RhB, 20 mg/L) in 50 min under visible light irradiation, which is 7.3 times 2.4 higher than that CdS, respectively. Various test results indicate improved activity composites can be attributed formation heterojunctions. Specifically, heterojunctions enhance separation photogenerated carriers effectively suppress recombination electrons holes, thereby improving overall reaction. Moreover, presence optimizes material's band structure, facilitating more carrier transport, further enhances photodegradation Radical quenching experiments confirmed hydroxyl radicals (·OH − ) superoxide radical anions (·O played dominant roles process. Additionally, composite material also demonstrates good stability reproducibility. research provides evidence dye significantly rational design catalysts consisting semiconductors MOFs.

Language: Английский

Citations

0
Therapeutic Frontiers in Nanozyme-Based Cancer Treatment: Advances, Challenges, and Future Directions DOI Open Access

D.M. Silva,

A.I. Kuruppu

Vidyodaya Journal of Science, Journal Year: 2024, Volume and Issue: 27(02)

Published: Dec. 30, 2024

Nanozymes, artificial nanomaterials mimicking enzyme activity, are at the forefront of innovative cancer therapies, particularly in chemodynamic therapy (CDT), photodynamic (PDT), and photothermal (PTT). Their capacity to selectively generate reactive oxygen species under tumor-specific conditions, including low pH high H₂O₂ levels, facilitates targeted induction cell death while minimizing damage healthy tissues. When integrated with PDT or PTT, nanozymes enhance oxidative stress promote immunogenic death, further amplifying anti-tumor immune responses. Recent advances single-atom intelligent have shown promise overcoming therapeutic limitations, such as tumor hypoxia suppression modulating microenvironment boost treatment efficacy. Additionally, ongoing preclinical clinical evaluations highlight potential synergistically immunotherapy outcomes. advantages over traditional enzymes, stability, tunability, cost-effectiveness, ability maintain catalytic activity hostile environments, position transformative agents therapy. However, their translation faces significant challenges, biocompatibility concerns, delivery inefficiencies sites, stringent regulatory hurdles, which require comprehensive research solutions address. Despite these advancements nanozyme design functionalization continue pave way for more effective safer applications will be discussed detail this review.Keywords: Cancer therapy, Nanomaterial, ROS, (PTT)

Language: Английский

Citations

0