Pathogens,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1075 - 1075
Published: Dec. 7, 2024
Non-typhoidal
Salmonella
species
are
one
of
the
leading
causes
gastrointestinal
disease
in
North
America,
to
a
significant
burden
on
healthcare
system
resulting
huge
economic
impact.
Consequently,
early
detection
food
supply,
accordance
with
safety
regulations,
is
crucial
for
protecting
public
health,
preventing
outbreaks,
and
avoiding
serious
losses.
A
variety
techniques
have
been
employed
detect
presence
this
pathogen
including
culture-based,
immunological,
molecular
methods.
The
present
review
summarizes
these
methods
highlights
recent
updates
promising
emerging
technologies,
aptasensors,
Surface
Plasmon
Resonance
(SPR),
Enhanced
Raman
Spectroscopy
(SERS).
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(4), P. 352 - 352
Published: April 11, 2024
Salmonella
enterica
serovar
Typhimurium
(S.
Typhimurium),
a
foodborne
pathogen
that
poses
significant
public
health
risks
to
humans
and
animals,
presents
formidable
challenge
due
its
antibiotic
resistance.
This
study
explores
the
potential
of
Lactobacillus
acidophilus
(L.
1.3251)
probiotics
as
an
alternative
strategy
combat
resistance
associated
with
S.
infection.
In
this
investigation,
twenty-four
BALB/c
mice
were
assigned
four
groups:
non-infected,
non-treated
group
(CNG);
infected,
(CPG);
fed
L.
but
not
infected
(LAG);
challenged
(LAST).
The
results
revealed
reduction
in
levels
feces
mice,
along
restored
weight
improved
overall
LAST
compared
CPG.
feeding
was
found
downregulate
pro-inflammatory
cytokine
mRNA
induced
by
while
upregulating
anti-inflammatory
cytokines.
Additionally,
it
influenced
expression
transcript,
encoding
tight
junction
protein,
oxidative
stress-induced
enzymes,
apoptosis-related
expression.
Furthermore,
LEfSe
analysis
demonstrated
shift
abundance
critical
commensal
genera
LAST,
essential
for
maintaining
gut
homeostasis,
metabolic
reactions,
responses,
butyrate
production.
Transcriptomic
2173
upregulated
506
downregulated
differentially
expressed
genes
(DEGs)
vs.
Functional
these
DEGs
highlighted
their
involvement
immunity,
metabolism,
cellular
development.
Kyoto
Encyclopedia
Genes
Genome
(KEGG)
pathway
indicated
role
tumor
necrosis
factor
(TNF),
mitogen-activated
protein
kinase
(MAPK),
chemokine,
Forkhead
box
O
(FOXO),
transforming
growth
(TGF-β)
signaling
pathway.
Moreover,
fecal
metabolomic
identified
929
differential
metabolites,
enrichment
observed
valine,
leucine,
isoleucine,
taurine,
glycine,
other
metabolites.
These
findings
suggest
supplementation
promotes
beneficial
mitigating
Salmonella-induced
intestinal
disruption
modulating
barrier
integrity,
metabolism.
Biotechnology Journal,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 1, 2025
Abstract
Salmonella
is
a
common
foodborne
zoonotic
pathogen
that
poses
great
threat
to
human
health
and
breeding
industry.
The
rapid
detection
of
necessary
for
early
prevention
control.
In
this
study,
subtractive
inhibition
assay
(SIA)
based
on
surface
plasmon
resonance
(SPR)
the
was
developed.
Mouse‐specific
monoclonal
antibody
3B3
against
membrane
protein
PagN
first
incubated
with
.
unbound
free
separated
using
sequential
process
centrifugation
then
detected
an
immobilized
goat
anti‐mouse
immunoglobulin
G
polyclonal
SPR
sensor
chip.
This
SIA‐SPR
method
showed
excellent
sensitivity
limit
about
300
CFU
mL
−1
sensitive
different
serotypes
strains
but
not
non‐
strains.
It
able
detect
in
contaminated
water
milk
powder
at
less
than
10
2
3
,
respectively,
which
consistent
bacterial
plate
count
results.
addition,
could
be
used
evaluate
lysis
effect
phages
bacteria.
Since
culturing
needs
more
48
h,
has
potential
clinical
For
our
knowledge,
report
method.
Foods,
Journal Year:
2025,
Volume and Issue:
14(5), P. 744 - 744
Published: Feb. 22, 2025
Biosensors
are
innovative
and
cost-effective
analytical
devices
that
integrate
biological
recognition
elements
(bioreceptors)
with
transducers
to
detect
specific
substances
(biomolecules),
providing
a
high
sensitivity
specificity
for
the
rapid
accurate
point-of-care
(POC)
quantitative
detection
of
selected
biomolecules.
In
meat
production
chain,
their
application
has
gained
attention
due
increasing
demand
enhanced
food
safety,
quality
assurance,
fraud
detection,
regulatory
compliance.
can
foodborne
pathogens
(Salmonella,
Campylobacter,
Shiga-toxin-producing
E.
coli/STEC,
L.
monocytogenes,
etc.),
spoilage
bacteria
indicators,
contaminants
(pesticides,
dioxins,
mycotoxins),
antibiotics,
antimicrobial
resistance
genes,
hormones
(growth
promoters
stress
hormones),
metabolites
(acute-phase
proteins
as
inflammation
markers)
at
different
modules
along
from
livestock
farming
packaging
in
farm-to-fork
(F2F)
continuum.
By
real-time
data
biosensors
enable
early
interventions,
reducing
health
risks
(foodborne
outbreaks)
associated
contaminated
meat/meat
products
or
sub-standard
products.
Recent
advancements
micro-
nanotechnology,
microfluidics,
wireless
communication
have
further
sensitivity,
specificity,
portability,
automation
biosensors,
making
them
suitable
on-site
field
applications.
The
integration
blockchain
Internet
Things
(IoT)
systems
allows
acquired
management,
while
artificial
intelligence
(AI)
machine
learning
(ML)
enables
processing,
analytics,
input
risk
assessment
by
competent
authorities.
This
promotes
transparency
traceability
within
fostering
consumer
trust
industry
accountability.
Despite
biosensors'
promising
potential,
challenges
such
scalability,
reliability
complexity
matrices,
approval
still
main
challenges.
review
provides
broad
overview
most
relevant
aspects
current
state-of-the-art
development,
challenges,
opportunities
prospective
applications
regular
use
safety
monitoring,
clarifying
perspectives.
Discover Nano,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: April 2, 2025
This
paper
provides
a
comprehensive
overview
of
the
diverse
applications
and
innovations
nanoparticles
in
detection
Salmonella.
It
encompasses
range
novel
methods,
including
efficient
enrichment,
nucleic
acid
extraction,
immunoassays,
tests,
biosensors,
emerging
strategies
with
potential
for
future
applications.
The
surface
modification
specific
antibodies
or
ligands
enables
to
achieve
highly
selective
capture
Salmonella,
while
optimizing
extraction
process
improving
efficiency.
employment
immunological
tests
markedly
enhances
specificity
sensitivity
reaction,
thereby
determination
results.
Moreover,
distinctive
physicochemical
properties
enhance
sensitivity,
selectivity,
stability
facilitating
rapid
advancement
bio-detection
technologies.
is
particularly
noteworthy
that
there
has
been
significant
application
innovative
research
nanozymes
molecular
assays.
progress
not
only
resulted
enhanced
efficiency
but
also
facilitated
innovation
improvement
As
nanotechnologies
continue
advance,
use
metal
oxide
Salmonella
likely
become
more
promising
reliable
strategy
ensuring
food
safety
public
health.
