International Academic Journal Faculty of Tourism and Hotel Management,
Journal Year:
2023,
Volume and Issue:
9(1), P. 31 - 70
Published: June 1, 2023
The
publication
of
the
ancient
Egyptian
medical
papyri
starting
from
2nd
half
19th
century
revealed
their
ingenuity
in
field
medicine
almost
all
its
specialties;
concern
for
mental
and
psychological
health
was
on
par
with
that
physical
health.
Egyptians
perfectly
balanced
work
leisure,
which
had
a
positive
impact
health;
overall
wellbeing
is
largely
reflected
level
civilizational
superiority.
Nevertheless,
experiencing
negative
emotions,
head
injuries,
or
other
problems
inevitable,
adversely
individuals.
This
study
deals
selection
disorders
diseases
(Depression,
Epilepsy,
Paraphilia,
Dementia,
Hysteria).
It
aims
to
tackle
concept
various
methods
treatment
these
diseases,
whether
magical
approaches,
Egypt
during
Graeco-Roman
Period
mutual
influence
Classical
world.
Journal of Advanced Research,
Journal Year:
2023,
Volume and Issue:
64, P. 249 - 262
Published: Nov. 22, 2023
One-third
of
people
with
epilepsy
continue
to
experience
seizures
despite
treatment
existing
anti-seizure
medications
(ASMs).
The
failure
modern
ASMs
substantially
improve
prognosis
has
been
partly
attributed
overreliance
on
acute
rodent
models
in
preclinical
drug
development
as
they
do
not
adequately
recapitulate
the
mechanisms
human
epilepsy,
are
labor-intensive
and
unsuitable
for
high-throughput
screening
(HTS).
There
is
an
urgent
need
find
human-relevant
HTS
identify
novel
compounds.
This
paper
developed
new
ASMs.
14
natural
compounds
(α-asarone,
curcumin,
vinpocetine,
magnolol,
ligustrazine,
osthole,
tanshinone
IIA,
piperine,
gastrodin,
quercetin,
berberine,
chrysin,
schizandrin
A
resveratrol)
were
assessed
their
ability
suppress
epileptiform
activity
measured
by
multi-electrode
arrays
(MEA)
neural
cultures
derived
from
induced
pluripotent
stem
cells
(iPSCs).
In
parallel,
tested
effects
zebrafish
mouse
models,
which
have
widely
used
these
compared.
Two
approved
positive
controls.
Epileptiform
could
be
iPSCs-derived
neurons
following
4-aminopyridine
(4-AP)
inhibited
standard
ASMs,
carbamazepine,
phenytoin.
Eight
significantly
neurons.
Among
them,
α-asarone,
osthole
showed
significant
both
mice.
Comparative
analysis
that
ineffective
model
also
no
or
models.
Our
findings
support
use
first-line
properties
exclude
Effective
may
then
selected
animal
evaluation
before
clinical
testing.
integrated
approach
efficiency
developing
Brazilian Journal of Medical and Biological Research,
Journal Year:
2024,
Volume and Issue:
57
Published: Jan. 1, 2024
Research
suggests
that
physical
exercise
is
associated
with
prevention
and
management
of
chronic
diseases.
The
influence
on
brain
function
metabolism
the
mechanisms
involved
are
well
documented
in
literature.
This
review
provides
a
comprehensive
overview
potential
implications
molecular
benefits
Parkinson's
disease,
Alzheimer's
epilepsy.
Here,
we
present
an
effects
various
aspects
function.
To
this
end,
conducted
extensive
literature
search
PubMed,
Web
Science,
Google
Scholar
databases
to
identify
articles
published
past
two
decades.
delves
into
key
including
modulation
neuroinflammation,
neurotrophic
factors,
synaptic
plasticity.
Moreover,
explored
role
advancing
therapeutic
strategies
for
these
In
conclusion,
highlights
importance
regular
as
complementary
non-pharmacological
treatment
individuals
neurological
disorders
such
Alzheimer's,
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1524 - 1524
Published: Nov. 28, 2024
Mitochondrial
encephalopathy,
lactic
acidosis,
and
stroke-like
episodes
(MELAS)
syndrome
is
a
complex
mitochondrial
disorder
characterized
by
wide
range
of
systemic
manifestations.
Key
clinical
features
include
recurrent
episodes,
seizures,
muscle
weakness,
exercise
intolerance,
sensorineural
hearing
loss,
diabetes,
progressive
neurological
decline.
MELAS
most
commonly
associated
with
mutations
in
DNA,
particularly
the
m.3243A>G
mutation
MT-TL1
gene,
which
encodes
tRNALeu
(CUR).
These
impair
protein
synthesis,
leading
to
defective
oxidative
phosphorylation
energy
failure
at
cellular
level.
The
presentation
severity
vary
widely
among
patients,
but
often
results
significant
morbidity
reduced
life
expectancy
because
deterioration.
Current
management
largely
focused
on
conservative
care,
including
anti-seizure
medications,
arginine
or
citrulline
supplementation,
high-dose
taurine,
dietary
therapies.
However,
these
therapies
do
not
address
underlying
genetic
mutations,
leaving
many
patients
substantial
disease
burden.
Emerging
experimental
treatments,
such
as
gene
therapy
replacement
techniques,
aim
correct
defects
offer
potential
curative
strategies.
Further
research
essential
understand
pathophysiology
MELAS,
optimize
current
therapies,
develop
novel
treatments
that
may
significantly
improve
patient
outcomes
extend
survival.
International Academic Journal Faculty of Tourism and Hotel Management,
Journal Year:
2023,
Volume and Issue:
9(1), P. 31 - 70
Published: June 1, 2023
The
publication
of
the
ancient
Egyptian
medical
papyri
starting
from
2nd
half
19th
century
revealed
their
ingenuity
in
field
medicine
almost
all
its
specialties;
concern
for
mental
and
psychological
health
was
on
par
with
that
physical
health.
Egyptians
perfectly
balanced
work
leisure,
which
had
a
positive
impact
health;
overall
wellbeing
is
largely
reflected
level
civilizational
superiority.
Nevertheless,
experiencing
negative
emotions,
head
injuries,
or
other
problems
inevitable,
adversely
individuals.
This
study
deals
selection
disorders
diseases
(Depression,
Epilepsy,
Paraphilia,
Dementia,
Hysteria).
It
aims
to
tackle
concept
various
methods
treatment
these
diseases,
whether
magical
approaches,
Egypt
during
Graeco-Roman
Period
mutual
influence
Classical
world.
