Phillygenin inhibits neuroinflammation and promotes functional recovery after spinal cord injury via TLR4 inhibition of the NF-κB signaling pathway

Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 48, P. 133 - 145

Published: Aug. 8, 2024

Spinal cord injuries (SCIs) trigger a cascade of detrimental processes, encompassing neuroinflammation and oxidative stress (OS), ultimately leading to neuronal damage. Phillygenin (PHI), isolated from forsythia, is used in number biomedical applications, known exhibit anti-neuroinflammation activity. In this study, we investigated the role mechanistic ability PHI activation microglia-mediated subsequent apoptosis following SCI.

Language: Английский

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High concentration hydrogen attenuates sepsis-induced acute kidney injury by promoting mitochondrial biogenesis and fusion

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113410 - 113410

Published: Oct. 20, 2024

Sepsis is a major cause of mortality among critical patients. Acute kidney injury (AKI) the common complication in patients with sepsis, characterized by rapid deterioration renal function. The purpose this study to assess impact inhaling high concentration hydrogen on septic mice AKI and examine involvement mitochondria process. High does not hypoxia can alleviate improve 7-day survival mice. Inflammatory factors are markedly elevated serum tissues CLP group which dramatically down-regulated hydrogen. activities both antioxidant enzymes significantly reduced after CLP, whereas increases SOD CAT. MMP found be lower effect reversed trend ATP content corresponded that MMP. There substantial downregulation PGC-1α, Nrf2, TFAM protein group. Drp1 expression higher compared Sham group, while opposite observed for MFN2. Hydrogen reverse these changes. Inhalation acute injury, survival, inflammatory response oxidative stress mechanism may related inhibit mitochondrial fission promote fusion biogenesis.

Language: Английский

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Important Role of Mitochondrial Dysfunction in Immune Triggering and Inflammatory Response in Rheumatoid Arthritis

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 11631 - 11657

Published: Dec. 1, 2024

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, primarily characterized by chronic symmetric synovial inflammation and erosive bone destruction.Mitochondria, the primary site of cellular energy production, play a crucial role in metabolism possess homeostatic regulation capabilities. Mitochondrial function influences differentiation, activation, survival both immune non-immune cells involved RA pathogenesis. If organism experiences hypoxia, genetic predisposition, oxidative stress, it leads to mitochondrial dysfunction, which further affects cell metabolism, proliferation, apoptosis, signaling, causing onset progression RA; and, becoming increasingly important treatment RA.In this review, we examine structure mitochondria, analyze potential causes dysfunction RA, focus on mechanisms triggers disorders RA. We also explore effects osteoblasts, emphasizing its key response processes Furthermore, discuss biological that regulate homeostasis, are great importance for prevention

Language: Английский

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The genomic mosaic of mitochondrial dysfunction: Decoding nuclear and mitochondrial epigenetic contributions to maternally inherited diabetes and deafness pathogenesis

Heliyon, Journal Year: 2024, Volume and Issue: 10(14), P. e34756 - e34756

Published: July 1, 2024

Maternally inherited diabetes and deafness (MIDD) is a complex disorder characterized by multiorgan clinical manifestations, including diabetes, hearing loss, ophthalmic complications. This pilot study aimed to elucidate the intricate interplay between nuclear mitochondrial genetics, epigenetic modifications, their potential implications in pathogenesis of MIDD.

Language: Английский

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The multifaceted modulation of mitochondrial metabolism in tumorigenesis

Mitochondrion, Journal Year: 2024, Volume and Issue: 80, P. 101977 - 101977

Published: Nov. 4, 2024

Language: Английский

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Genetic landscape of primary mitochondrial diseases in children and adults using molecular genetics and genomic investigations of mitochondrial and nuclear genome

Orphanet Journal of Rare Diseases, Journal Year: 2024, Volume and Issue: 19(1)

Published: Nov. 12, 2024

Primary mitochondrial diseases (PMD) are one of the most common metabolic genetic disorders. They due to pathogenic variants in genome (mtDNA) or nuclear (nDNA) that impair function and/or structure. We hypothesize there is overlap between PMD and other mimicking PMD. For this reason, we performed a retrospective cohort study.

Language: Английский

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S32, a Novel 3-Acetylaminocoumarin Compound, Exerts Neuroprotective Effects through the Inhibition of Neuroinflammation and Oxidative Stress In Vitro and In Vivo

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 16(1), P. 85 - 94

Published: Dec. 12, 2024

Neuroinflammation and oxidative stress are key factors leading to neuronal injury. In this study, we investigated the role of S32, a novel 3-acetylaminocoumarin compound, in ameliorating injury induced by neuroinflammation vitro vivo. First, found that S32 reduced expression levels p-P65 p-P38, inhibited nuclear translocation P65, lowered pro-inflammatory LPS-induced BV2 cells, which indicated had an antineuroinflammatory effect. Second, cell culture medium was used as conditioned establish model damage PC12 cells. It level ROS increased mitochondrial membrane potential can protect cells against medium-induced Next, decrease viability caused H2O2, damage, decreased ROS, MMP, activated AKT ERK pathways, Bcl-2 levels, Bax Cleaved-Caspase3 indicating ameliorated damaging effects H2O2-induced Finally, exerted apoptosis-inhibiting mice. conclusion, study first demonstrated reduce neuroinflammation-induced injury, exerting indirect protective effect on neurons, also exert direct neurons reducing stress.

Language: Английский

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Mitochondrial Oncology: Present Insights and Future Perspectives

Advances in biochemistry in health and disease, Journal Year: 2024, Volume and Issue: unknown, P. 181 - 199

Published: Jan. 1, 2024

Language: Английский

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