Lipid Metabolism and Statin Therapy in Neurodegenerative Diseases: An Endocrine View

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 282 - 282

Published: April 18, 2025

Background/aim: A growing body of evidence suggests a link between dyslipidemias and neurodegenerative diseases, highlighting the crucial role lipid metabolism in health central nervous system. The aim our work was to provide an update on this topic, with focus clinical practice from endocrinological point view. Endocrinologists, being experts management dyslipidemias, can play key prevention treatment conditions, through precocious effective profile optimization. Methods: literature scanned identify trials correlation studies association dyslipidemia, statin therapy, following diseases: Alzheimer’s disease (AD), Parkisons’s (PD), Multiple sclerosis (MS), Amyotrophic lateral (ALS). Results: Impaired homeostasis, such as that frequently observed patients affected by obesity diabetes, is related AD, PD, other cognitive deficits aging. AD dementias are now real priority problem. In United States, there approximately 7 million subjects aged 65 older living dementias, number projected grow 12 coming decades. Lipid-lowering therapy statins strategy reducing serum low-density lipoprotein cholesterol normal range concentrations and, therefore, cardiovascular risk; moreover, have been reported positive effect diseases. Conclusions: Several pieces research found inconsistent information review. There no use ALS incidence. More has emerged regarding AD/PD. However, further large-scale prospective randomized control required properly understand issue.

Language: Английский

Update on the correlation between mitochondrial function and osteonecrosis of the femoral head osteocytes

Redox Report, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 18, 2025

Mitochondrial health is maintained in a steady state through mitochondrial dynamics and autophagy processes. Recent studies have identified healthy mitochondria as crucial regulators of cellular function survival. This process involves adenosine triphosphate (ATP) synthesis by oxidative phosphorylation (OXPHOS), regulation calcium metabolism inflammatory responses, intracellular stress management. In the skeletal system, they participate behaviors responses osteoblasts, osteoclasts, chondrocytes, osteocytes to external stimuli. Indeed, damage or dysfunction occurs development few bone diseases. For example, may lead an imbalance osteoblasts resulting osteoporosis, osteomalacia, poor production, chondrocyte death infiltration osteoarthritis are main causes cartilage degeneration due damage. However, opposite exists for osteosarcoma, where overactive able accelerate proliferation migration osteosarcoma cells, which major disease feature. Bone dynamic organ play fundamental role all regions tissue involved regulating integrity. review examines impact physiological on osteocyte summarizes microscopic molecular mechanisms underlying its effects. It highlights that targeted therapies focusing be beneficial survival, providing new insight diagnosis, prevention, treatment diseases associated with death.

Language: Английский

Triglyceride-Glucose Index and 28-Day All-Cause Mortality in Critically Ill Obese Patients: A MIMIC-IV Database Analysis

Journal of clinical lipidology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский