ETV5 reduces androgen receptor expression and induces neural stem–like properties during neuroendocrine prostate cancer development DOI Creative Commons
Jongeun Lee, Ji‐Ho Park,

Yunjung Hur

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(12)

Published: March 21, 2025

Neuroendocrine prostate cancer (NEPC), an aggressive subtype induced by hormone therapy, lacks effective treatments. This study explored the role of E26 transformation-specific variant 5 (ETV5) in NEPC development. Analysis multiple datasets revealed that is characterized significantly elevated ETV5 expression compared to other subtypes. increased progressively under therapy through epigenetic modifications. neural stem–like features cells and facilitated their differentiation into treatment conditions, both vitro vivo. Our molecular mechanistic identified PBX3 TLL1 as target genes contribute overexpression–induced castration resistance stemness. Notably, obeticholic acid, inhibitor this study, exhibited promising efficacy suppressing highlights a key transcription factor facilitates development underscores its potential therapeutic for subtype.

Language: Английский

ETV5 reduces androgen receptor expression and induces neural stem–like properties during neuroendocrine prostate cancer development DOI Creative Commons
Jongeun Lee, Ji‐Ho Park,

Yunjung Hur

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(12)

Published: March 21, 2025

Neuroendocrine prostate cancer (NEPC), an aggressive subtype induced by hormone therapy, lacks effective treatments. This study explored the role of E26 transformation-specific variant 5 (ETV5) in NEPC development. Analysis multiple datasets revealed that is characterized significantly elevated ETV5 expression compared to other subtypes. increased progressively under therapy through epigenetic modifications. neural stem–like features cells and facilitated their differentiation into treatment conditions, both vitro vivo. Our molecular mechanistic identified PBX3 TLL1 as target genes contribute overexpression–induced castration resistance stemness. Notably, obeticholic acid, inhibitor this study, exhibited promising efficacy suppressing highlights a key transcription factor facilitates development underscores its potential therapeutic for subtype.

Language: Английский

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