Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(6), P. 1086 - 1105.e13

Published: May 23, 2024

The olfactory epithelium undergoes neuronal regeneration from basal stem cells and is susceptible to neuroblastoma (ONB), a rare tumor of unclear origins. Employing alterations in Rb1/Trp53/Myc (RPM), we establish genetically engineered mouse model high-grade metastatic ONB exhibiting NEUROD1

Language: Английский

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Update on olfactory neuroblastoma

Virchows Archiv, Journal Year: 2024, Volume and Issue: 484(4), P. 567 - 585

Published: Feb. 22, 2024

Language: Английский

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Advancing Precision Medicine: The Role of Genetic Testing and Sequencing Technologies in Identifying Biological Markers for Rare Cancers

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(8)

Published: April 1, 2025

ABSTRACT Background Genetic testing and sequencing technologies offer a comprehensive understanding of cancer genetics, providing rapid cost‐effective solutions. In particular, these advanced play an important role in assessing the complexities rare types affecting several systems including bone, endocrine, digestive, vascular, soft tissue. This review will explore how genetic have contributed to identification biomarkers across diagnostic, therapeutic, prognostic stages, thereby advancing PM. Methods A literature search was conducted PubMed (MEDLINE), EMBASE, Web Science using keywords related technologies, testing, cancer. There were no restrictions on language, methodology, age, or publication date. Both primary secondary research involving humans animals considered. Results practice, fluorescence situ hybridization, karyotype, microarrays other tests are mainly applied identify specific alterations mutations associated with progression. Sequencing such as next generation sequencing, polymerase chain reaction, whole genome exome enable analysis millions DNA fragments. These techniques assess structure, changes, gene expression profiles, epigenetic variations. Consequently, they help detect main intrinsic markers that crucial for personalizing diagnosis, treatment options, assessments, leading better patient prognosis. highlights why methods now considered tools research. However, still face multiple limitations, false positive results, limited precision, high costs. Conclusion significantly field by enabling key precision treatment, Despite existing their integration into clinical fields continues improve development personalized medicine strategies complex types.

Language: Английский

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Proceedings of the 2023 North American Society of Head and Neck Pathology Companion Meeting, New Orleans, LA, March 12, 2023: Navigating New Developments in High Grade Sinonasal Neuroendocrine and Neuroectodermal Neoplasms

Head and Neck Pathology, Journal Year: 2023, Volume and Issue: 17(2), P. 299 - 312

Published: May 15, 2023

Language: Английский

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Spatiotemporal dynamics exhibited by horizontal basal cells reveal a pro-neurogenic pathway during injury-induced olfactory epithelium regeneration

iScience, Journal Year: 2024, Volume and Issue: 27(5), P. 109600 - 109600

Published: March 27, 2024

Horizontal basal cells (HBCs) mediate olfactory epithelium (OE) regeneration following severe tissue injury. The dynamism of the post-injury environment is well illustrated by

Language: Английский

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Horizontal basal cells self-govern their neurogenic potential during injury-induced regeneration of the olfactory epithelium

Development, Journal Year: 2023, Volume and Issue: 150(12)

Published: June 1, 2023

Horizontal basal cells (HBCs) residing within severely damaged olfactory epithelium (OE) mediate OE regeneration by differentiating into odorant-detecting sensory neurons (OSNs) and other tissue supporting non-neuronal cell types. Depending on both type integrity, the Notch signaling pathway can either positively or negatively regulate resident stem activity. Although Notch1 specifies HBC dormancy in uninjured OE, little is known about how HBCs are influenced following injury. Here, we show that depend a functional inversion of to appropriately regeneration. At 24 h post-injury, enhance Notch1-mediated signaling. Moreover, at 3 days post-injury when regenerating composed multiple layers, enrich ligand, Dll1. Notably, HBC-specific knockout increases quiescence impairs differentiation neuronal progenitors OSNs. Interestingly, complete Dll1 only decreases HBC-derived These data underscore context-dependent nature Furthermore, they reveal their own neurogenic potential after

Language: Английский

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Top IHC/ISH Hacks for and Molecular Surrogates of Poorly Differentiated Sinonasal Small Round Cell Tumors

Head and Neck Pathology, Journal Year: 2024, Volume and Issue: 18(1)

Published: Feb. 5, 2024

Abstract Background Poorly differentiated sinonasal small round cell tumors (SRCTs) are rare and heterogeneous, posing challenges in diagnosis treatment. Methods Recent advances molecular findings diagnostic refinement have promoted better understanding management of these tumors. Results The newly defined emerging entities demonstrate diverse morphologies, specific genomic signatures, clinical behavior from conventional counterparts. In this review SRCTs, emphasis is placed on the approach with employment a pertinent panel immunohistochemistry studies and/or tests, fine-tuned to latest WHO 5 classification sinonasal/paranasal personalized Conclusion Specifically, focuses epithelial neuroectodermal derivation.

Language: Английский

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Olfactory Neuroblastoma and Olfactory Carcinoma

Surgical pathology clinics, Journal Year: 2024, Volume and Issue: 17(4), P. 637 - 652

Published: Aug. 24, 2024

Language: Английский

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Olfactory neuroblastoma

Mini-invasive Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Originating from the olfactory neuroepithelium, neuroblastoma is a rare malignant tumor of nasal cavity that typically affects adults between ages 35 and 70. Clinical presentation predominantly consists nonspecific symptoms such as obstruction, drainage or epistaxis, thus illustrating need for thorough diagnostic workup. In addition to complete head neck examination, rigid endoscopy, biopsy imaging are necessary establish definitive diagnosis well plan treatment. Computed tomography (CT) magnetic resonance (MRI) primary modalities utilized assess bony invasion soft tissue involvement, respectively. Hyams grading system provides histologic assessment disease severity while various staging systems correlate anatomic location/progression. Treatment relies on both surgical intervention radiation. addition, ongoing research trials investigating therapeutic targets. Given risk recurrence, extended post-treatment surveillance remains necessary.

Language: Английский

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Sox2 and βIII-Tubulin as Biomarkers of Drug Resistance in Poorly Differentiated Sinonasal Carcinomas

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(10), P. 1504 - 1504

Published: Oct. 18, 2023

Poorly differentiated sinonasal carcinomas (PDCs) are tumors that have a poor prognosis despite advances in classical treatment. Predictive and prognostic markers new personalized treatments could improve the oncological outcomes of patients. In this study, we analyzed SOX2 βIII-tubulin as biomarkers therapeutic impacts on these tumors. The cohort included 57 cases PDCs: 36 undifferentiated carcinoma (SNUC) cases, 13 olfactory neuroblastoma (ONB) 8 neuroendocrine (SNEC) cases. Clinical follow-up data were available for 26 Sox2 expression was detected using immunohistochemistry 6 (75%) SNEC 19 (53%) SNUC (46%) ONB absence staining correlated with higher rate recurrence (p = 0.015), especially distant recurrence. majority showed expression, strong positivity 85%, 75%, 64% SNEC, ONB, respectively. Tumors stronger demonstrated longer disease-free survival than those no or low 0.049). is common poorly has utility.

Language: Английский

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