The role of autophagy in neurodegenerative disease

Nature Medicine, Journal Year: 2013, Volume and Issue: 19(8), P. 983 - 997

Published: Aug. 1, 2013

Language: Английский

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Oxidative stress and autophagy: the clash between damage and metabolic needs

Cell Death and Differentiation, Journal Year: 2014, Volume and Issue: 22(3), P. 377 - 388

Published: Sept. 26, 2014

Autophagy is a catabolic process aimed at recycling cellular components and damaged organelles in response to diverse conditions of stress, such as nutrient deprivation, viral infection genotoxic stress. A growing amount evidence recent years argues for oxidative stress acting the converging point these stimuli, with reactive oxygen species (ROS) nitrogen (RNS) being among main intracellular signal transducers sustaining autophagy. This review aims providing novel insight into regulatory pathways autophagy glucose amino acid well their tight interconnection metabolic networks redox homeostasis. The role nitrosative also discussed light its harmful both biomolecules mediator through reversible posttranslational modifications thiol-containing proteins. redox-independent relationship between antioxidant response, occurring p62/Keap1/Nrf2 pathway, addressed order provide wide perspective upon Herein, we attempt afford an overview complex crosstalk DNA damage (DDR), focusing on activated ROS RNS overproduction. Along lines, direct indirect DDR dissected depth.

Language: Английский

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Autophagy promotes ferroptosis by degradation of ferritin

Autophagy, Journal Year: 2016, Volume and Issue: 12(8), P. 1425 - 1428

Published: June 1, 2016

Macroautophagy/autophagy is an evolutionarily conserved degradation pathway that maintains homeostasis. Ferroptosis, a novel form of regulated cell death, characterized by production reactive oxygen species from accumulated iron and lipid peroxidation. However, the relationship between autophagy ferroptosis at genetic level remains unclear. Here, we demonstrated contributes to ferritin in fibroblasts cancer cells. Knockout or knockdown Atg5 (autophagy-related 5) Atg7 limited erastin-induced with decreased intracellular ferrous levels, Remarkably, NCOA4 (nuclear receptor coactivator 4) was selective cargo for autophagic turnover (namely ferritinophagy) ferroptosis. Consistently, inhibition inhibited suppressed In contrast, overexpression increased promoted These findings provide insight into interplay death.

Language: Английский

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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Nature, Journal Year: 2014, Volume and Issue: 509(7498), P. 105 - 109

Published: March 28, 2014

Language: Английский

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Early versus Late Parenteral Nutrition in Critically Ill Adults

New England Journal of Medicine, Journal Year: 2011, Volume and Issue: 365(6), P. 506 - 517

Published: June 30, 2011

Controversy exists about the timing of initiation parenteral nutrition in critically ill adults whom caloric targets cannot be met by enteral alone.In this randomized, multicenter trial, we compared early (European guidelines) with late (American and Canadian intensive care unit (ICU) to supplement insufficient nutrition. In 2312 patients, was initiated within 48 hours after ICU admission (early-initiation group), whereas 2328 not before day 8 (late-initiation group). A protocol for applied both groups, insulin infused achieve normoglycemia.Patients late-initiation group had a relative increase 6.3% likelihood being discharged alive earlier from (hazard ratio, 1.06; 95% confidence interval [CI], 1.00 1.13; P=0.04) hospital CI, P=0.04), without evidence decreased functional status at discharge. Rates death rates survival 90 days were similar two groups. Patients group, as early-initiation fewer infections (22.8% vs. 26.2%, P=0.008) lower incidence cholestasis (P<0.001). The reduction 9.7% proportion patients requiring more than 2 mechanical ventilation (P=0.006), median 3 duration renal-replacement therapy (P=0.008), mean health costs €1,110 (about $1,600) (P=0.04).Late associated faster recovery complications, initiation. (Funded Methusalem program Flemish government others; EPaNIC ClinicalTrials.gov number, NCT00512122.).

Language: Английский

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Ferroptosis is an autophagic cell death process

Cell Research, Journal Year: 2016, Volume and Issue: 26(9), P. 1021 - 1032

Published: Aug. 12, 2016

Language: Английский

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Sugar for the brain: the role of glucose in physiological and pathological brain function

Trends in Neurosciences, Journal Year: 2013, Volume and Issue: 36(10), P. 587 - 597

Published: Aug. 20, 2013

Language: Английский

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Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

Biochemical Journal, Journal Year: 2011, Volume and Issue: 441(2), P. 523 - 540

Published: Dec. 21, 2011

Reactive oxygen and nitrogen species change cellular responses through diverse mechanisms that are now being defined. At low levels, they signalling molecules, at high damage organelles, particularly the mitochondria. Oxidative associated mitochondrial dysfunction may result in energy depletion, accumulation of cytotoxic mediators cell death. Understanding interface between stress adaptation death then is important for understanding redox biology disease pathogenesis. Recent studies have found one major sensor this switch autophagy. Autophagic activities mediated by a complex molecular machinery including more than 30 Atg (AuTophaGy-related) proteins 50 lysosomal hydrolases. Autophagosomes form membrane structures, sequester damaged, oxidized or dysfunctional intracellular components direct them to lysosomes degradation. This autophagic process sole known mechanism turnover. It has been speculated autophagy abnormal function oxidative nitrative stress. Emerging investigations provided new how mitochondria (also as mitophagy) controlled, impact on The present review highlights recent regulation autophagy, context basic mitophagy. Furthermore, we discuss reactive species. relevant degenerative diseases which occurs over time, both pathways play role.

Language: Английский

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Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

Molecular and Cellular Biology, Journal Year: 2011, Volume and Issue: 32(1), P. 2 - 11

Published: Oct. 25, 2011

Living cells are adaptive self-sustaining systems. They strictly depend on the sufficient supply of oxygen, energy, and nutrients from outside in order to sustain their internal organization. However, as autonomous entities they able monitor appropriately adapt any critical fluctuation environment. In case insufficient external nutrient or augmented energy demands, start extensively digest own interior. This process, known macroautophagy, comprises transport cytosolic portions entire organelles lysosomal compartment via specific double-membrane vesicles, called autophagosomes. Although upregulated under restriction, a low level basal autophagy is likewise crucial cellular homeostasis. On other hand, have avoid excessive enduring self-digestion. The delicate balance between production consumption demanding task. complex protein network that senses precisely reacts environmental changes thus mainly regulated by rapid reversible posttranslational modifications such phosphorylation. review focuses serine/threonine kinases AMP-activated kinase, mammalian target rapamycin (mTOR), unc-51-like kinase 1/2 (Ulk1/2), three interconnected major junctions within regulating signaling network.

Language: Английский

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NRF2 and the Hallmarks of Cancer

Cancer Cell, Journal Year: 2018, Volume and Issue: 34(1), P. 21 - 43

Published: May 3, 2018

Language: Английский

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