Frontiers in Cell and Developmental Biology,
Journal Year:
2022,
Volume and Issue:
10
Published: March 8, 2022
Chemical
modifications
of
RNA
molecules
regulate
both
metabolism
and
fate.
The
deposition
function
these
are
mediated
by
the
actions
writer,
reader,
eraser
proteins.
At
cellular
level,
several
processes
including
cell
death,
proliferation,
senescence,
differentiation,
migration,
metabolism,
autophagy,
DNA
damage
response,
liquid-liquid
phase
separation.
Emerging
evidence
demonstrates
that
play
active
roles
in
physiology
etiology
multiple
diseases
due
to
their
pervasive
functions.
Here,
we
will
summarize
recent
advances
regulatory
functional
role
functions,
emphasizing
context-specific
mammalian
systems.
As
m
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Sept. 22, 2022
RNA
modifications
have
become
hot
topics
recently.
By
influencing
processes,
including
generation,
transportation,
function,
and
metabolization,
they
act
as
critical
regulators
of
cell
biology.
The
immune
abnormality
in
human
diseases
is
also
a
research
focus
progressing
rapidly
these
years.
Studies
demonstrated
that
participate
the
multiple
biological
processes
cells,
development,
differentiation,
activation,
migration,
polarization,
thereby
modulating
responses
are
involved
some
related
diseases.
In
this
review,
we
present
existing
knowledge
functions
underlying
mechanisms
modifications,
N6-methyladenosine
(m6A),
5-methylcytosine
(m5C),
N1-methyladenosine
(m1A),
N7-methylguanosine
(m7G),
N4-acetylcytosine
(ac4C),
pseudouridine
(Ψ),
uridylation,
adenosine-to-inosine
(A-to-I)
editing,
summarize
their
roles
Via
regulating
can
pathogenesis
diseases,
such
cancers,
infection,
inflammatory
autoimmune
We
further
highlight
challenges
future
directions
based
on
knowledge.
All
all,
review
will
provide
helpful
well
novel
ideas
for
researchers
area.
Annual Review of Biochemistry,
Journal Year:
2023,
Volume and Issue:
92(1), P. 175 - 198
Published: April 5, 2023
Chemical
modifications
on
mRNA
represent
a
critical
layer
of
gene
expression
regulation.
Research
in
this
area
has
continued
to
accelerate
over
the
last
decade,
as
more
are
being
characterized
with
increasing
depth
and
breadth.
have
been
demonstrated
influence
nearly
every
step
from
early
phases
transcript
synthesis
nucleus
through
their
decay
cytoplasm,
but
many
cases,
molecular
mechanisms
involved
these
processes
remain
mysterious.
Here,
we
highlight
recent
work
that
elucidated
roles
throughout
life
cycle,
describe
gaps
our
understanding
remaining
open
questions,
offer
some
forward-looking
perspective
future
directions
field.
Seminars in Cancer Biology,
Journal Year:
2022,
Volume and Issue:
86, P. 18 - 31
Published: May 25, 2022
RNA
binding
proteins
that
act
at
the
post-transcriptional
level
display
a
richness
of
mechanisms
to
modulate
transcriptional
output
and
respond
changing
cellular
conditions.
The
family
IGF2BP
recognize
mRNAs
modified
by
methylation
lengthen
their
lifecycle
in
context
stable
ribonucleoprotein
particles
promote
cancer
progression.
They
are
emerging
as
key
'reader'
epitranscriptomic
field,
driving
fate
bound
substrates
under
physiological
disease
Recent
developments
field
include
recognition
noncoding
play
crucial
roles
mediating
pro-growth
features
family,
not
only
regulated
targets,
but
also
modulators
function
themselves.
In
this
review,
we
summarize
regulatory
link
molecular
role
m6A
modification
readers
phenotype,
thus
providing
comprehensive
insight
into
function.
