iRadiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
ABSTRACT
Alzheimer's
disease
(AD)
is
a
neurodegenerative
characterized
by
progressive
decline
in
cognitive
functions.
Given
that
AD
undermines
the
quality
of
life
for
millions
and
has
an
extended
asymptomatic
period,
exploring
full
pathogenesis
seeking
optimal
therapeutic
solution
have
become
critical
imperative.
This
allows
researchers
to
intervene,
delay,
potentially
prevent
progression.
Several
clinical
imaging
methods
are
utilized
routinely
diagnose
monitor
AD,
such
as
magnetic
resonance
(MRI),
functional
(fMRI),
positron
emission
tomography
(PET),
single
photon
computed
(SPECT).
Nevertheless,
due
their
intrinsic
drawbacks
restrictions,
radiation
concerns,
high
cost,
long
acquisition
time,
low
spatial
resolution,
applications
research
limited,
especially
at
cellular
molecular
levels.
In
contrast,
optical
microscopic
overcome
these
limitations,
offering
variety
approaches
with
distinct
advantages
explore
pathology
on
diverse
models.
this
review,
we
provide
comprehensive
overview
commonly
techniques
introduce
contributions
image
amyloid
beta
(Aβ)
species.
These
include
fluorescence
microscopy
(FM),
confocal
(CM),
two‐photon
(TPFM),
super‐resolution
(SRM),
expansion
(ExM),
light‐sheet
(LSFM).
addition,
some
related
topics,
development
near‐infrared
(NIR)
Aβ
probes,
plaque
hypothesis,
oligomer
roles
microglia
astrocytes
We
believe
continue
play
indispensable
role
deciphering
advancing
strategies.
physica status solidi (RRL) - Rapid Research Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 16, 2025
Digital
holographic
microscopy
(DHM)
resolution,
constrained
by
the
emission
wavelength
and
numerical
aperture,
can
be
enhanced
through
structured
illumination
techniques.
This
article
introduces
a
method
utilizing
speckle
pattern
generated
Scotch
tape
diffuser
to
achieve
super‐resolution
(SR)
quantitative
phase
imaging.
The
SRAD‐DIHM
system
(SR
using
alternating
direction
of
multipliers
(ADMM)
in
digital
in‐line
microscopy)
combines
speckled
ADMM‐based
computations
for
SR.
By
incorporating
sparsity‐based
regularization,
mitigates
noise
inherent
illumination.
provides
threefold
improvement
lateral
resolution
ninefold
axial
over
conventional
DHM.
work
effectively
uses
label‐free
imaging
metrology
nanoparticles.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 2152 - 2152
Published: Feb. 27, 2025
Mitochondria
are
involved
in
a
wide
array
of
critical
cellular
processes
from
energy
production
to
cell
death.
The
morphology
(size
and
shape)
mitochondrial
compartments
is
highly
responsive
both
intracellular
extracellular
conditions,
making
these
organelles
dynamic.
Nutrient
levels
stressors
inside
outside
the
inform
balance
fission
fusion
recycling
components
known
as
mitophagy.
study
its
implications
human
disease
microbial
engineering
have
gained
significant
attention
over
past
decade.
yeast
Saccharomyces
cerevisiae
offers
valuable
model
system
for
studying
mitochondria
due
ability
survive
without
respiring,
genetic
tractability,
high
degree
similarity
across
eukaryotic
species.
Here,
we
review
how
interplay
between
fission,
fusion,
biogenesis,
mitophagy
regulates
dynamic
nature
networks
mammalian
systems
with
an
emphasis
on
organism.
Additionally,
examine
crucial
role
inter-organelle
interactions,
particularly
endoplasmic
reticulum,
regulating
dynamics.
dysregulation
any
gives
rise
abnormal
morphologies,
which
serve
distinguishing
features
numerous
diseases,
including
Parkinson's
disease,
Alzheimer's
cancer.
Notably,
models
contributed
revealing
underlying
mechanisms
driving
states.
In
addition
furthering
our
understanding
pathologic
processes,
aberrant
morphologies
increasing
interest
seemingly
distant
field
metabolic
engineering,
following
discovery
that
compartmentalization
certain
biosynthetic
pathways
within
can
significantly
improve
chemical
production.
this
review,
utility
organism
healthy
states,
explore
nascent
discuss
methods
available
quantification
classification
key
morphologies.
iRadiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
ABSTRACT
Alzheimer's
disease
(AD)
is
a
neurodegenerative
characterized
by
progressive
decline
in
cognitive
functions.
Given
that
AD
undermines
the
quality
of
life
for
millions
and
has
an
extended
asymptomatic
period,
exploring
full
pathogenesis
seeking
optimal
therapeutic
solution
have
become
critical
imperative.
This
allows
researchers
to
intervene,
delay,
potentially
prevent
progression.
Several
clinical
imaging
methods
are
utilized
routinely
diagnose
monitor
AD,
such
as
magnetic
resonance
(MRI),
functional
(fMRI),
positron
emission
tomography
(PET),
single
photon
computed
(SPECT).
Nevertheless,
due
their
intrinsic
drawbacks
restrictions,
radiation
concerns,
high
cost,
long
acquisition
time,
low
spatial
resolution,
applications
research
limited,
especially
at
cellular
molecular
levels.
In
contrast,
optical
microscopic
overcome
these
limitations,
offering
variety
approaches
with
distinct
advantages
explore
pathology
on
diverse
models.
this
review,
we
provide
comprehensive
overview
commonly
techniques
introduce
contributions
image
amyloid
beta
(Aβ)
species.
These
include
fluorescence
microscopy
(FM),
confocal
(CM),
two‐photon
(TPFM),
super‐resolution
(SRM),
expansion
(ExM),
light‐sheet
(LSFM).
addition,
some
related
topics,
development
near‐infrared
(NIR)
Aβ
probes,
plaque
hypothesis,
oligomer
roles
microglia
astrocytes
We
believe
continue
play
indispensable
role
deciphering
advancing
strategies.
