The Therapeutic Effects of Dendropanax morbiferus Lév. Water Leaf Extracts in a Rheumatoid Arthritis Animal Model DOI Creative Commons
Dongho Lee, Jong Min Kim,

Chang-Soo Cho

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 548 - 548

Published: May 1, 2025

(1) Background: Rheumatoid arthritis (RA) is a chronic inflammatory condition known for its symptoms of joint damage and cartilage breakdown. Current treatments frequently result in adverse effects show restricted efficacy the long term. Dendropanax morbiferus, plant recognized bioactive properties, demonstrates promise treatment conditions. The objective this study was to examine therapeutic properties morbiferus Lév. water extract (DMWE) RA through utilization vitro vivo models. (2) Methods: Ultra-high-performance liquid chromatography (UPLC) analysis used identify compounds DMWE. Antioxidant activity evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical-scavenging assays. experiments involved CHON-001 cells with DMWE order assess impacts on inflammation matrix metalloproteinase (MMP) expression. impact Janus Kinase 2 (JAK2) Signal Transducer Activator Transcription (STAT) signaling pathways also assessed. induced Balb/c mice who were subsequently treated varying doses morphology, edema, body weight. (3) Results: demonstrated substantial antioxidant hindered expression MMP-2 MMP-8 chondrocytes IL-1β. It additionally inhibited JAK2/STAT pathway diminished responses. Treatment living organisms led decrease swelling, improved weight regains, maintained structure, higher exhibiting similar those positive control, dexamethasone (Dexa). (4) Conclusions: found have excellent anti-inflammatory activities. In an RA-induced mouse model, DMWE-3 (500 mg/kg BW) effectively treat by reducing concentration pro-inflammatory factors preventing deformation.

Language: Английский

Research Progress on the Therapeutic Mechanisms of Stigmasterol for Multiple Diseases DOI Creative Commons
Juan Li, Xinhua Zheng, Jinxu Qi

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 1874 - 1874

Published: April 23, 2025

Stigmasterol is a plant-derived phytosterol that has attracted considerable attention because of its diverse biological activities and potential therapeutic applications. In this review, the chemical properties, biosynthesis, effects stigmasterol are exhaustively summarized. Furthermore, anti-inflammatory, antioxidant, anticancer, neuroprotective, hypolipidemic have been discussed. Findings from various in vitro vivo studies revealed treating diseases, including cancer, diabetes, neurological disorders, inflammatory conditions. The mechanisms underlying these also discussed, particularly emphasizing regulation key signaling pathways molecular targets, to further clarify role stigmasterol. This review would provide reference for exploring utility as agent, thereby contributing improvement human health.

Language: Английский

Citations

0
The Therapeutic Effects of Dendropanax morbiferus Lév. Water Leaf Extracts in a Rheumatoid Arthritis Animal Model DOI Creative Commons
Dongho Lee, Jong Min Kim,

Chang-Soo Cho

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 548 - 548

Published: May 1, 2025

(1) Background: Rheumatoid arthritis (RA) is a chronic inflammatory condition known for its symptoms of joint damage and cartilage breakdown. Current treatments frequently result in adverse effects show restricted efficacy the long term. Dendropanax morbiferus, plant recognized bioactive properties, demonstrates promise treatment conditions. The objective this study was to examine therapeutic properties morbiferus Lév. water extract (DMWE) RA through utilization vitro vivo models. (2) Methods: Ultra-high-performance liquid chromatography (UPLC) analysis used identify compounds DMWE. Antioxidant activity evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical-scavenging assays. experiments involved CHON-001 cells with DMWE order assess impacts on inflammation matrix metalloproteinase (MMP) expression. impact Janus Kinase 2 (JAK2) Signal Transducer Activator Transcription (STAT) signaling pathways also assessed. induced Balb/c mice who were subsequently treated varying doses morphology, edema, body weight. (3) Results: demonstrated substantial antioxidant hindered expression MMP-2 MMP-8 chondrocytes IL-1β. It additionally inhibited JAK2/STAT pathway diminished responses. Treatment living organisms led decrease swelling, improved weight regains, maintained structure, higher exhibiting similar those positive control, dexamethasone (Dexa). (4) Conclusions: found have excellent anti-inflammatory activities. In an RA-induced mouse model, DMWE-3 (500 mg/kg BW) effectively treat by reducing concentration pro-inflammatory factors preventing deformation.

Language: Английский

Citations

0