Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(8), P. 4679 - 4733
Published: April 15, 2024
The
review
presents
a
detailed
discussion
of
the
evolving
field
studying
interactions
between
ionic
liquids
(ILs)
and
biological
systems.
Originating
from
molten
salt
electrolytes
to
present
multiapplication
substances,
ILs
have
found
usage
across
various
fields
due
their
exceptional
physicochemical
properties,
including
excellent
tunability.
However,
with
systems
potential
influence
on
living
organisms
remain
largely
unexplored.
This
examines
cytotoxic
effects
cell
cultures,
biomolecules,
vertebrate
invertebrate
organisms.
Our
understanding
IL
toxicity,
while
growing
in
recent
years,
is
yet
nascent.
established
findings
include
correlations
harmful
ability
disturb
cellular
membranes,
trigger
oxidative
stress
cells,
cause
death
via
apoptosis.
Future
research
directions
proposed
distribution
within
compartments
organelles,
investigating
metabolic
transformations
cells
organisms,
analysis
proteins
involved
apoptosis,
correlation
studies
doses,
exposure
times
resulting
adverse
effects,
examination
subtoxic
concentrations
objects.
aims
serve
as
critical
current
body
knowledge
IL-related
toxicity
mechanisms.
Furthermore,
it
can
guide
researchers
toward
design
less
toxic
informed
use
drug
development
medicine.
