Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(2), P. 702 - 702
Published: Feb. 20, 2023
Advancements
in
the
fields
of
ionic
liquids
(ILs)
broaden
its
applications
not
only
traditional
use
but
also
different
pharmaceutical
and
biomedical
fields.
Ionic
“Solutions
for
Your
Success”
have
received
a
lot
interest
from
scientists
due
to
myriad
industry
drug
delivery
systems
as
well
targeting
diseases.
Solubility
is
critical
physicochemical
property
that
determines
drug’s
fate
at
target
site.
Many
promising
candidates
fail
various
phases
research
poor
solubility.
In
this
context,
are
regarded
effective
poorly
soluble
medicines.
ILs
able
combine
anions/cations
with
other
cations/anions
produce
salts
satisfy
concept
behind
ILs.
The
important
characteristics
modularity
their
properties
depending
on
application.
review
highlights
recent
advancement
further
deliver
drugs
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(1), P. 151 - 151
Published: Jan. 22, 2024
The
unique
properties
of
ionic
liquids
(ILs),
such
as
structural
tunability,
good
solubility,
chemical/thermal
stability,
favorable
biocompatibility,
and
simplicity
preparation,
have
led
to
a
wide
range
applications
in
the
pharmaceutical
biomedical
fields.
ILs
can
not
only
speed
up
chemical
reaction
process,
improve
yield,
reduce
environmental
pollution
but
also
many
problems
field
medicine,
poor
drug
product
crystal
instability,
biological
activity,
low
delivery
efficiency.
This
paper
presents
systematic
concise
analysis
recent
advancements
further
from
aspects
synthesis,
analysis,
solubilization,
engineering.
Additionally,
it
explores
field,
covering
carriers,
stabilization
proteins,
antimicrobials,
bioactive
liquids.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 27, 2024
Abstract
Transdermal
drug
delivery
has
been
regarded
as
an
alternative
to
oral
and
subcutaneous
injection.
However,
needleless
transdermal
of
biomacromolecules
remains
a
challenge.
Herein,
platform
based
on
biocompatible
fluorocarbon
modified
chitosan
(FCS)
is
developed
achieve
highly
efficient
non-invasive
including
antibodies
antigens.
The
formed
nanocomplexes
exhibits
effective
penetration
ability
via
both
intercellular
transappendageal
routes.
Non-invasive
immune
checkpoint
blockade
induces
stronger
responses
for
melanoma
in
female
mice
reduces
systemic
toxicity
compared
intravenous
Moreover,
SARS-CoV-2
vaccine
results
comparable
humoral
immunity
well
improved
cellular
memory
that
achieved
with
Additionally,
FCS-based
protein
systems
demonstrate
rabbit
porcine
skins.
Thus,
may
provide
compelling
opportunity
overcome
the
skin
barrier
bio-therapeutics.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(8), P. 4679 - 4733
Published: April 15, 2024
The
review
presents
a
detailed
discussion
of
the
evolving
field
studying
interactions
between
ionic
liquids
(ILs)
and
biological
systems.
Originating
from
molten
salt
electrolytes
to
present
multiapplication
substances,
ILs
have
found
usage
across
various
fields
due
their
exceptional
physicochemical
properties,
including
excellent
tunability.
However,
with
systems
potential
influence
on
living
organisms
remain
largely
unexplored.
This
examines
cytotoxic
effects
cell
cultures,
biomolecules,
vertebrate
invertebrate
organisms.
Our
understanding
IL
toxicity,
while
growing
in
recent
years,
is
yet
nascent.
established
findings
include
correlations
harmful
ability
disturb
cellular
membranes,
trigger
oxidative
stress
cells,
cause
death
via
apoptosis.
Future
research
directions
proposed
distribution
within
compartments
organelles,
investigating
metabolic
transformations
cells
organisms,
analysis
proteins
involved
apoptosis,
correlation
studies
doses,
exposure
times
resulting
adverse
effects,
examination
subtoxic
concentrations
objects.
aims
serve
as
critical
current
body
knowledge
IL-related
toxicity
mechanisms.
Furthermore,
it
can
guide
researchers
toward
design
less
toxic
informed
use
drug
development
medicine.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(12), P. 2608 - 2608
Published: June 8, 2023
The
proposed
electro-responsive
hydrogel
has
great
benefit
for
transdermal
drug
delivery
system
(TDDS)
applications.
To
improve
the
physical
or
chemical
properties
of
hydrogels,
a
number
researchers
have
previously
studied
mixing
efficiencies
blended
hydrogels.
However,
few
studies
focused
on
improving
electrical
conductivity
and
We
developed
conductive
by
alginate
with
gelatin
methacrylate
(GelMA)
silver
nanowire
(AgNW).
demonstrated
that
tensile
strength
hydrogels
were
increased
factor
1.8
blending
GelMA
was
enhanced
18
addition
AgNW.
Furthermore,
GelMA-alginate-AgNW
(Gel-Alg-AgNW)
patch
enabled
on-off
controllable
release,
indicating
57%
doxorubicin
release
in
response
to
stimulation
(ES)
application.
Therefore,
this
could
be
useful
smart
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(3)
Published: Jan. 16, 2024
Abstract
Microemulsion‐based
gels
(μEGs)
are
smart
colloidal
carriers,
superior
to
traditional
topical
formulations
due
formulation
simplicity,
structural
flexibility,
high
stability,
and
controlled
delivery
of
drugs
through
biofilms.
Here,
we
report
a
new
μEG
for
application
an
anti‐inflammatory
drug,
celecoxib
(CXB).
For
this,
the
μE
system
was
formulated
using
olive
oil
(~10
%),
Water
(~15
Tween‐80
(~67.5
%)
Span‐80
(~7.5
enhanced
loading
CXB
(~2.0
wt.%),
then
gelled
semisolid
by
addition
polyethylene
glycol
6000
(PEG‐6000)
(2.0
wt.%)
modulate
passage
across
skin‐barriers.
Optical
microscopy
showed
transition
from
water‐in‐oil
(w/o)
oil‐in‐water
(o/w)
bicontinuous
networks.
Dynamic
light
scattering
electron
micrographs
demonstrate
very
fine
unimodal
assembly
CXB‐μE
nanodroplets
(~65
nm),
which
didn't
amalgamate
form
spherical
CXB‐μEG
(~95
nm)
after
gelation.
Moreover,
FTIR
analysis
effective
encapsulation
into
hydrophobic
microenvironment
with
no
observable
chemical
interaction
between
excipients,
further
verified
peak‐to‐peak
measurement
fluorescence.
Further,
ex‐vivo
permeation
persistent
(>99
within
10
hours
at
pH=5.5
rabbit
skin
barrier.
This
demonstrates
sustained
release
in
enhancement
transdermal
over
its
conventional
formulations.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(5), P. 3110 - 3123
Published: April 15, 2024
Transdermal
drug
delivery
systems
(TDDS)
are
a
promising
and
innovative
approach
for
breast
cancer
treatment,
offering
advantages
such
as
noninvasiveness,
potential
localized
prolonged
while
minimizing
systemic
side
effects
through
avoiding
first-pass
metabolism.
Utilizing
the
distinctive
characteristics
of
hydrogels,
their
biocompatibility,
versatility,
higher
loading
capabilities,
in
present
work,
we
prepared
ionic
hydrogels
synergistic
interaction
between
liquids
(ILs),
choline
alanine
([Cho][Ala]),
proline
([Cho][Pro])
with
oleic
acid
(OA).
ILs
used
study
biocompatible
enhance
solubility
5-fluorouracil
(5-FU),
whereas
OA
is
known
chemical
penetration
enhancer.
The
concentration-dependent
(OA)
change
morphological
aggregates,
that
is,
from
cylindrical
micelles
to
worm-like
was
formed
both
characterized
by
SANS
measurement,
interactions
involved
were
confirmed
FTIR
spectroscopy.
have
excellent
mechanical
properties,
which
studied
rheology
morphology
FE-SEM
analysis.
vitro
skin
permeation
revealed
penetrated
255
times
([Cho][Ala])
250
more
compared
PBS
after
48
h.
Those
exhibited
capability
lipid
keratin
arrangements
within
layer,
thereby
enhancing
transdermal
5-FU.
Both
exhibit
biocompatibility
normal
cell
lines
(L-132
cells)
well
cancerous
(MCF-7
cells),
demonstrating
over
92%
viability
h
lines.
In
vitro,
cytotoxicity
5-FU-loaded
evaluated
on
MCF-7
HeLa
These
results
indicate
investigated
nontoxic
enable
hydrophilic
drugs,
making
them
viable
option
effectively
treating
cancer.
