Impact of β-Carotene on the Structural and Thermal Behavior of β-Lactoglobulin: A Study Integrating Spectroscopy, Docking, and MD DOI

Bahareh Yousefi,

Saad Ali Alshehri, Sadegh Farhadian

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141965 - 141965

Published: March 1, 2025

Language: Английский

A multifaceted approach to explore the formation of EM of paracetamol with improved solubility and its composite with graphene oxide DOI

Madhur Babu Singh,

M. Aslam,

Arun Arun

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: 425, P. 127220 - 127220

Published: Feb. 22, 2025

Language: Английский

Citations

0
Biophysical and structural insights into Azamethiphos-DNA interactions DOI
Pratik Singh, Priyanka Gopi,

Majji Sai Sudha Rani

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 334, P. 125934 - 125934

Published: Feb. 23, 2025

Language: Английский

Citations

0
Electric field-induced conformational dynamics of CA9: a potential biomarker for glioblastoma multiforme DOI
Jiajia Shi,

Yanwei Fang,

Zhuo Zuo

et al.

Journal of Biomolecular Structure and Dynamics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: Feb. 26, 2025

GBM, a malignant brain tumor prevalent in adults, can be treated using Electric field (EF) therapy. However, the underlying mechanism of EF-based GBM therapy is not well understood. In this study, we used bioinformatics and MD analysis to explore CA9 EF for GBM. was identified as differentially expressed gene (DEG) sensitive stimulation GEO TCGA integrated analysis. Elevated expression associated with reduced overall survival patients, indicating that an adverse prognostic factor. Single-cell data demonstrated significantly higher cells than normal cells, suggesting could EF-sensitive biomarker GSVA suggested related hypoxia glucose metabolism glioblastoma. simulations were employed examine impact (0 V/nm ≤ E 0.5 V/nm) on conformation protein, including RMSF, RMSD, Rg, secondary structure, dipole moment. The protein structure altered different intensities, affecting motion atoms intensity-dependent manner. number hydrogen bonds intensity increased, disrupted bonds. Additionally, affected moment characteristic time. Besides, family highly conserved. Overall, showed potential EF, presenting prospective target therapeutic interventions EF-mediated treatment.

Language: Английский

Citations

0
β-Lactoglobulin and sorghum phenolic compounds molecular binding: Interaction mechanism and thermal stability impact DOI
Carolina Thomaz dos Santos D’Almeida, Anne Caroline de Albuquerque Sales, Ana Augusta Odorissi Xavier

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 478, P. 143632 - 143632

Published: Feb. 28, 2025

Language: Английский

Citations

0
Impact of β-Carotene on the Structural and Thermal Behavior of β-Lactoglobulin: A Study Integrating Spectroscopy, Docking, and MD DOI

Bahareh Yousefi,

Saad Ali Alshehri, Sadegh Farhadian

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141965 - 141965

Published: March 1, 2025

Language: Английский

Citations

0