Magnolol from Magnolia officinalis inhibits Neopestalotiopsis ellipsospora by damaging the cell membrane DOI Creative Commons

Jiying Zhang,

Jianmei Yao,

Chiyu Ma

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 22, 2024

Tea gray blight disease is a significant threat to the tea industry. In this study, biological activity approach was utilized investigate efficacy of green fungicides from Magnolia officinalis stem bark against Neopestalotiopsis ellipsospora. The active compounds were isolated and purified, their structures elucidated. vitro in vivo screenings revealed that n-hexane extract, which contained magnolol honokiol, exhibited strong N. ellipsospora, showing complete inhibition at 100 mg/L. EC50 values honokiol 5.11 6.09 mg/L, respectively. Mechanistically, found disrupt ellipsospora invasion by damaging cell membrane, increasing permeability, causing leakage intracellular substances. Transcriptome analysis treatment downregulates membrane-related genes leads enrichment lipid metabolism pathway genes. This study inhibits growth affecting compromising membrane integrity.

Language: Английский

Lactobacillus-based probiotics restore gut microbial balance in weaned rabbits: Insights into dietary modulation and molecular docking analysis DOI
Khalid Abd El Ghany,

L. O. Mallasiy,

Shimaa A. Haredy

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106466 - 106466

Published: March 1, 2025

Language: Английский

Citations

0
Magnolol from Magnolia officinalis inhibits Neopestalotiopsis ellipsospora by damaging the cell membrane DOI Creative Commons

Jiying Zhang,

Jianmei Yao,

Chiyu Ma

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 22, 2024

Tea gray blight disease is a significant threat to the tea industry. In this study, biological activity approach was utilized investigate efficacy of green fungicides from Magnolia officinalis stem bark against Neopestalotiopsis ellipsospora. The active compounds were isolated and purified, their structures elucidated. vitro in vivo screenings revealed that n-hexane extract, which contained magnolol honokiol, exhibited strong N. ellipsospora, showing complete inhibition at 100 mg/L. EC50 values honokiol 5.11 6.09 mg/L, respectively. Mechanistically, found disrupt ellipsospora invasion by damaging cell membrane, increasing permeability, causing leakage intracellular substances. Transcriptome analysis treatment downregulates membrane-related genes leads enrichment lipid metabolism pathway genes. This study inhibits growth affecting compromising membrane integrity.

Language: Английский

Citations

0