Pharmacokinetic Assessments of Ursolic Loaded-Dendrimer Complex DOI
Aditya Singh, Valeed Ahmad Ansari, Tarique Mahmood

et al.

Current Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 20(7), P. 538 - 556

Published: Aug. 29, 2024

Background: This study investigates the application of polyamidoamine (PAMAM) dendrimers as an innovative drug delivery approach for enhancing pharmacokinetic profile ursolic acid (UA), a pentacyclic triterpenoid with multifaceted therapeutic properties. UA, sourced from plants like Sanguisorba officinalis and Salvia officinalis, has been extensively studied its pharmacological characteristics, including anti-inflammatory, antioxidant, anti-diabetic properties, recognized in Traditional Chinese Medicine (TCM). The clinical utility UA is hampered by low bioavailability, which attributed to hydrophobic nature. To address this limitation, we explore use PAMAM dendrimers, known their potential. Methods: UA-PAMAM G0 were synthesized varying molar ratios. Characterization included size analysis, PDI, zeta potential determination. FTIR confirmed chemical structure. Male SD rats acclimatized administered control suspension UA-G0 dendrimer complex orally. Blood samples collected analysis. obtained IAEC approval. Results: complexes exhibited sizes based on ratios, 2:1 ratio showing significantly smaller dimensions. successful conjugation. In study, demonstrated higher plasma concentrations than alone, indicated increased Cmax AUC values. results suggest enhanced oral bioavailability complex. Conclusion: synthesis variations analysis revealed improved compared alone. These findings highlight compounds bridging gap between traditional herbal medicine modern strategies. Further research can broader applications such systems.

Language: Английский

Dendrimer-Encapsulated Curcumin: Illuminating pathways to cancer treatment excellence DOI

Maryam Mahjubin-Tehran,

Niloofar Khandan-Nasab,

Prashant Kesharwani

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 218, P. 113358 - 113358

Published: July 31, 2024

Language: Английский

Citations

1
Pharmacokinetic Assessments of Ursolic Loaded-Dendrimer Complex DOI
Aditya Singh, Valeed Ahmad Ansari, Tarique Mahmood

et al.

Current Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 20(7), P. 538 - 556

Published: Aug. 29, 2024

Background: This study investigates the application of polyamidoamine (PAMAM) dendrimers as an innovative drug delivery approach for enhancing pharmacokinetic profile ursolic acid (UA), a pentacyclic triterpenoid with multifaceted therapeutic properties. UA, sourced from plants like Sanguisorba officinalis and Salvia officinalis, has been extensively studied its pharmacological characteristics, including anti-inflammatory, antioxidant, anti-diabetic properties, recognized in Traditional Chinese Medicine (TCM). The clinical utility UA is hampered by low bioavailability, which attributed to hydrophobic nature. To address this limitation, we explore use PAMAM dendrimers, known their potential. Methods: UA-PAMAM G0 were synthesized varying molar ratios. Characterization included size analysis, PDI, zeta potential determination. FTIR confirmed chemical structure. Male SD rats acclimatized administered control suspension UA-G0 dendrimer complex orally. Blood samples collected analysis. obtained IAEC approval. Results: complexes exhibited sizes based on ratios, 2:1 ratio showing significantly smaller dimensions. successful conjugation. In study, demonstrated higher plasma concentrations than alone, indicated increased Cmax AUC values. results suggest enhanced oral bioavailability complex. Conclusion: synthesis variations analysis revealed improved compared alone. These findings highlight compounds bridging gap between traditional herbal medicine modern strategies. Further research can broader applications such systems.

Language: Английский

Citations

0