Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Introduction Cancer remains a significant health challenge, and nanoparticles (NPs) are promising candidates for cancer treatment due to their unique physicochemical properties ability selectively target tumour cells. Two-dimensional (2D) nanomaterials, such as MXenes, have attracted interest electronic structures, optical properties, catalytic abilities, exceptional attributes. MXenes highly suitable surface functionalization or modification, make them various applications in the biological field. Silver-based compounds shown remarkable potential biomedical fields, with silver oxide (Ag₂O) NPs finding domains. The fabrication of titanium carbide (Ti₃C₂)-Ag₂O heterostructures has been investigated anti-cancer by conducting cell viability assays on different lines. Aim To synthesize characterize Ti₃C₂-Ag₂O, assess its vitro activity. Materials methods Ti₃C₂ synthesis begins dissolving Ti₃AlC₂ powder 50% v/v hydrofluoric (HF) acid solution, allowing aluminium be etched away. This process should conducted continuous stirring 24 48 hours at ambient temperature. Following this, filter resulting suspension eliminate particles HF, subsequently wash MXene distilled water until neutral pH is attained. then dispersed ethanol, sonication deionized (DI) an alternative solvent employed achieve exfoliation into monolayer few-layer MXenes. prepare Ag₂O NPs, dissolve nitrate (AgNO₃) DI create 0.1 M concurrently separate sodium hydroxide (NaOH) solution. Introduce NaOH solution AgNO₃ while precipitate observed. mixture filtered, washed water, dried 60°C 12 hours. fabricate MXene-Ag₂O composite, disperse nanoflakes through sonication, incorporate stir Finally, centrifuge resultant isolate it solvent, dry under vacuum conditions. Results presence nanosheets was observed, high crystallinity compound confirmed X-ray diffraction (XRD), energy-dispersive spectroscopy (EDS), scanning electron microscopy (SEM) analyses. These tests verified that free impurities exhibited properties. Conclusion achieved structural characterization methods, including SEM, XRD, EDS. SEM provided detailed insights morphology distribution nanostructures, XRD EDS phase purity elemental composition. Functionalization strategies were enhance stability bioactivity nanocomposites. In evaluations demonstrated activity, indicating Ti₃C₂-Ag₂O composites effectively inhibit growth.

Language: Английский