Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

In this study, we synthesized a new material, Schiff base PEI-CA/N-GQDs, from the reaction of 4-hydroxy-3-methoxy-cinnamaldehyde (CA) with polyethyleneimine-functionalized N-doped graphene quantum dots (PEI N-GQDs). The material was experimentally characterized by FT-IR, UV-Vis, SEM, EDX, AFM, XRD, and TGA, as well theoretically DFT method. addition to their biological activities, cytotoxic, apoptotic cell cycle arresting effects were investigated in human epithelial neuroblastoma (SH-SY5Y) cells. According UV-Vis data, observed that exhibits phenol-imine/keto-amine tautomerism, phenomenon common 2-hydroxy bases help explain various properties material. Furthermore, predominantly exists keto-amine form. demonstrated favorable electron transfer properties, making it suitable for electrochemical applications. We showed binds DNA through an electrostatic interaction causes oxidative hydrolytic cleavage DNA, which results increase ROS cell, activation CASPASE-3, leading cells undergo apoptosis, inhibiting division G1/S phase. believe chemical Schiff-based PEI N-GQDs make them superior carrier molecule cancer treatment. Furthermore anticancer PEI-CA/N-GQDs suggest potential therapeutic agent neuroblastoma.

Language: Английский