A Quantum Chemical, Biological, and Experimental Analysis of Newly Synthesized Schiff-based PEI CA/N-GQDs Nanomaterials: Evaluation of Anticancer Potential in Human Neuroblastoma Cell DOI Creative Commons
Murat Kılıç, Buket Altınok Güneş, Omer Faruk Kırlangıç

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract In this study, we synthesized a new material, Schiff base PEI-CA/N-GQDs, from the reaction of 4-hydroxy-3-methoxy-cinnamaldehyde (CA) with polyethyleneimine-functionalized N-doped graphene quantum dots (PEI N-GQDs). The material was experimentally characterized by FT-IR, UV-Vis, SEM, EDX, AFM, XRD, and TGA, as well theoretically DFT method. addition to their biological activities, cytotoxic, apoptotic cell cycle arresting effects were investigated in human epithelial neuroblastoma (SH-SY5Y) cells. According UV-Vis data, observed that exhibits phenol-imine/keto-amine tautomerism, phenomenon common 2-hydroxy bases help explain various properties material. Furthermore, predominantly exists keto-amine form. demonstrated favorable electron transfer properties, making it suitable for electrochemical applications. We showed binds DNA through an electrostatic interaction causes oxidative hydrolytic cleavage DNA, which results increase ROS cell, activation CASPASE-3, leading cells undergo apoptosis, inhibiting division G1/S phase. believe chemical Schiff-based PEI N-GQDs make them superior carrier molecule cancer treatment. Furthermore anticancer PEI-CA/N-GQDs suggest potential therapeutic agent neuroblastoma.

Language: Английский

Development of Diaryl Hydrazones for Alleviation of Mitochondrial Oxidative Stress in Preeclampsia DOI

Maxim Mastyugin,

R. Bernadett Vlocskó,

Zsuzsanna K. Zsengellér

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Preeclampsia is a pregnancy-specific syndrome, linked to oxidative stress, affecting 5-8% of pregnancies, with no effective treatment available. Here, diaryl-hydrazones have been designed, synthesized, and investigated as mitochondria-targeting antioxidants reduce placental stress mitigate preeclampsia symptoms. The design, based on density functional theory studies, revealed that conjugated electron structure the NH-motif appeared explain their effect. Thirty compounds were synthesized tested in three assays, where they exhibited excellent radical scavenging activity, significantly greater than standard, Trolox. Based data, eight selected for cell-based assays. Oxidative was induced human trophoblast cells assessed whether reduced downstream antiangiogenic responses using ascorbic acid MitoTEMPO standards. pretreatment hydrazones mitochondrial superoxide sFLT-1 production H2O2-exposed cells, indicating anti-angiogenic response can be alleviated by these compounds.

Language: Английский

Citations

0
Excited-state antioxidant activity for Api based on external electric field-modulated ESIPT behavior: TD-DFT and molecular docking calculations DOI

Xingzhu Tang,

Ye Wang, Lingling Wang

et al.

Journal of Photochemistry and Photobiology B Biology, Journal Year: 2024, Volume and Issue: 262, P. 113087 - 113087

Published: Dec. 27, 2024

Language: Английский

Citations

1
Performance Study and Application of Antioxidant Peptides CHCIWM and CHCPWM DOI
Liang Dong, Jun Ma, Yanan Li

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(39)

Published: Oct. 1, 2024

Abstract When the level of reactive oxygen species (ROS) increases abnormally in body, it damages tissue cells and is closely related to occurrence various chronic diseases. Antioxidant peptides (APs) are a class active short with antioxidant capacity, which have great research value. In this paper, two APs were designed synthesized based on structural features APs: CHIWM (AP1) CHCPWM (AP2). The sites activities analyzed using quantum chemical density functional theory (DFT) method. all located indolyl heterocycle tryptophan residues, among AP1 has smaller energy gap single point energy. Multiple free radical scavenging assays showed that AP2 had stronger activity than positive control, glutathione (GSH). For DPPH radicals, IC50s values 0.613 mg/mL 0.606 mg/mL, respectively. cellular assays, both able scavenge ROS attenuate damage. conclusion, paper good potential be applied treatment diseases caused by oxidative

Language: Английский

Citations

0
Quercetin analogues of kojic acid as strong antioxidant derivatives: theoretical insights DOI

Cleison C. Lobato,

Daniel S. de Sousa,

Anne G. B. Cardoso

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140480 - 140480

Published: Oct. 1, 2024

Language: Английский

Citations

0
A Quantum Chemical, Biological, and Experimental Analysis of Newly Synthesized Schiff-based PEI CA/N-GQDs Nanomaterials: Evaluation of Anticancer Potential in Human Neuroblastoma Cell DOI Creative Commons
Murat Kılıç, Buket Altınok Güneş, Omer Faruk Kırlangıç

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract In this study, we synthesized a new material, Schiff base PEI-CA/N-GQDs, from the reaction of 4-hydroxy-3-methoxy-cinnamaldehyde (CA) with polyethyleneimine-functionalized N-doped graphene quantum dots (PEI N-GQDs). The material was experimentally characterized by FT-IR, UV-Vis, SEM, EDX, AFM, XRD, and TGA, as well theoretically DFT method. addition to their biological activities, cytotoxic, apoptotic cell cycle arresting effects were investigated in human epithelial neuroblastoma (SH-SY5Y) cells. According UV-Vis data, observed that exhibits phenol-imine/keto-amine tautomerism, phenomenon common 2-hydroxy bases help explain various properties material. Furthermore, predominantly exists keto-amine form. demonstrated favorable electron transfer properties, making it suitable for electrochemical applications. We showed binds DNA through an electrostatic interaction causes oxidative hydrolytic cleavage DNA, which results increase ROS cell, activation CASPASE-3, leading cells undergo apoptosis, inhibiting division G1/S phase. believe chemical Schiff-based PEI N-GQDs make them superior carrier molecule cancer treatment. Furthermore anticancer PEI-CA/N-GQDs suggest potential therapeutic agent neuroblastoma.

Language: Английский

Citations

0