Preparation of reversible temperature sensitive acrylamide terpolymer hydrogel for cascade drug loadings

Journal of Macromolecular Science Part A, Journal Year: 2025, Volume and Issue: 62(2), P. 187 - 199

Published: Jan. 20, 2025

As a drug delivery system with vast potential applications, hydrogels have garnered significant attention due to their unique loading mechanisms and effectiveness. In this paper, novel reversible thermosensitive hydrogel polymer, synthesized through copolymerization of mono-6-allyl-β-cyclodextrin, N-isopropylacrylamide, acrylamide, is introduced. This polymer formed three-dimensional network structure in water, featuring β-cyclodextrin hydrophobic cavities. The encapsulated molecules could be slowly progressively released from both the IR XRD analysis confirmed successful encapsulation target molecules, sodium salicylate naproxen sodium, within cavity its space. Specifically, when mass ratio N-isopropylacrylamide/acrylamide/mono-6-allyl-β-cyclodextrin was 9.8/0.2/0.5, demonstrated an initial gelation temperature 34.9 °C final 37 °C. expansion rate blank slightly higher than that drug-loaded hydrogel. Both drugs undergo sustained release hydrogel, adhering Fick's diffusion law, ensuring consistent 8 h maintaining for over 24 h, regardless rate. Within 30 days, degradation PBS exceeded 15%, while presence lysozyme more 40%. These properties render versatile candidate targeted biomedical offering strategies treating chronic diseases other conditions.

Language: Английский

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Structural Characterization and Stability Analysis of Lactobacillus Plantarum Heal 19 Microcapsules with Peanut Protein and Polysaccharides

Published: Jan. 1, 2025

Language: Английский

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Approaches for Inclusion Complexes of Ezetimibe with Cyclodextrins: Strategies for Solubility Enhancement and Interaction Analysis via Molecular Docking

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1686 - 1686

Published: Feb. 16, 2025

This study aimed to improve the solubility of ezetimibe (EZT), which has low aqueous solubility, by preparing complexes using β-cyclodextrin (β-CD) derivatives. Phase studies and Job's plot confirmed a high apparent stability constant for EZT with β-CD even higher constants its derivatives, establishing 1:1 stoichiometric ratio. The composites were prepared spray drying over range molar ratios, their physicochemical properties evaluated techniques such as scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR). Saturation in vitro dissolution tests revealed that increased CD ratios. EZT/RM-β-CD inclusion (ICs) EZT/DM-β-CD ICs exhibited similar was greater than EZT/HP-β-CD EZT/SBE-β-CD (where RM, DM, HP, SEB represent H, CH3, -CH2-CHOH-CH3 -(CH2)4-SO3Na synthetic respectively). Most complexes, except at 1:2 or showed superior compared commercial products. Molecular docking simulations within CD, revealing hydrogen bonds binding energies aligned trends. These findings suggest derivatives significantly highlighting potential developing more effective oral solid formulations hyperlipidemia treatment.

Language: Английский

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Advances in cyclodextrin-based materials: Anticancer and antimicrobial applications–A review (2021–2024)

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113672 - 113672

Published: April 1, 2025

Language: Английский

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