Dual Antioxidant and Cytotoxic Activities of Novel 1,2,3-Triazole-Decorated Unsymmetrical Monocarbonyl Curcumin Analogues DOI Creative Commons
Bayu Ardiansah,

Ahmad Farhan,

Novita Sari Nurhasanah

et al.

Case Studies in Chemical and Environmental Engineering, Journal Year: 2024, Volume and Issue: unknown, P. 101031 - 101031

Published: Nov. 1, 2024

Language: Английский

Design, Synthesis, and Biological Evaluation of Benzo[d]oxazole-2-thio and Oxazolo[4,5-b]pyridine-2-thio Derivatives: Molecular Docking, POM Analysis, In Silico Pharmacokinetics, and Pharmacophore Insights for Antitumor, GPCR, and Kinase Targets DOI
Pankaj B. Gour, Sumeer Ahmed,

Ramalingam Gajendhiran

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141705 - 141705

Published: Feb. 1, 2025

Language: Английский

Citations

0
The Current Landscape of 1,2,3‐triazole Hybrids With Anticancer Therapeutic Potential: Part II DOI

Zhi Xu,

Junna Liu

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(4)

Published: April 1, 2025

Chemotherapy has been identified as a validated and critically important strategy for the treatment of cancer, but multidrug resistance serious side effects remain grand challenges effective cancer therapy. This highlights urgent need development alternative chemical entities that can modulate more than one biological target with high specificity multitargeted mechanism action in disease progression pathway. 1,2,3-Triazole hybrids have potential to act on dual/multiple targets cells simultaneously possess potent broad-spectrum activity against various cancers, including drug-resistant forms. Thus, 1,2,3-triazole are valuable scaffolds eradication cancer. review provides comprehensive overview evolving landscape their vitro vivo anticancer potential, structure-activity relationships well mechanisms also discussed, covering articles published from 2021 onward.

Language: Английский

Citations

0
Facile synthesis of 6-Substituted Tryptanthrin Derivatives as Promising Anticancer Agents: In vitro, ADMET prediction, and Molecular docking studies DOI
Bhagyashri Rathod, Sachin Puri, Mohamed F. Alajmi

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142541 - 142541

Published: April 1, 2025

Language: Английский

Citations

0
Novel Triazole-Nucleoside Hybrids as Potential Antimicrobial Agents: Design, Synthesis, and Molecular Docking DOI
Mostafa E. Salem, Ibrahim Taha Radwan, Magdi E. A. Zaki

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140207 - 140207

Published: Sept. 1, 2024

Language: Английский

Citations

3
Synthesis and in vitro cytotoxic evaluation of pyrazolo[1,5-c]quinazoline-triazole conjugates DOI

Mohammad Reza Talebian,

Samad Nejad Ebrahimi,

Sajjad Azizi

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1322, P. 140625 - 140625

Published: Nov. 8, 2024

Language: Английский

Citations

2
Pyrazole-based N-phenyl pyrazolines: Synthesis, docking, and pharmacological evaluation DOI Creative Commons

Nargisbano A. Peerzade,

Shravan Y. Jadhav,

Raghunath B. Bhosale

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 11, P. 101793 - 101793

Published: Sept. 20, 2024

Language: Английский

Citations

1
Synthesis of Paracetamol‐Appended Bis 1,2,3‐Triazole Analogues as Anti‐Inflammatory Agents DOI

Vineesha Bathini,

Vishnu Thumma,

Veerabhadraiah Mallikanti

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(42)

Published: Nov. 1, 2024

Abstract Paracetamol‐based bis 1,2,3‐triazole analogues were synthesized involving copper‐catalyzed click chemistry protocol. The new compounds characterized by 1 H NMR, 13 C and mass spectral techniques. All the evaluated for their in vitro anti‐inflammatory properties using diclofenac as standard reference. compound 6b with chlorine fluorine functions displayed outstanding activity IC 50 values of 7.34 ± 0.45 µM 7.84 0.47 µM, respectively. Compound 6g methyl best 9.34 0.22 9.40 0.35 6i , 6k, 6f, 6a, 6e, 6h, 6j 6l exhibited promising respect to diclofenac. Using PyRx tool, molecular docking study against crystal structure COX‐2 proved binding efficacies notable interactions.

Language: Английский

Citations

0
Synthesis, biological screening, and in silico physicochemical analysis of new 1,2,3-triazolyl oleate esters DOI Creative Commons

Hilna Diana Sahaya,

Bayu Ardiansah, Sumi Hudiyono

et al.

Case Studies in Chemical and Environmental Engineering, Journal Year: 2024, Volume and Issue: 10, P. 101014 - 101014

Published: Nov. 9, 2024

Language: Английский

Citations

0
Design, Synthesis, Characterization and antibacterial activity of new 1,2,3-triazole linked nucleosides DOI Creative Commons
Aditya Aggarwal, Vikram Poria, Surender Singh

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 12, P. 101901 - 101901

Published: Nov. 15, 2024

Language: Английский

Citations

0
Dual Antioxidant and Cytotoxic Activities of Novel 1,2,3-Triazole-Decorated Unsymmetrical Monocarbonyl Curcumin Analogues DOI Creative Commons
Bayu Ardiansah,

Ahmad Farhan,

Novita Sari Nurhasanah

et al.

Case Studies in Chemical and Environmental Engineering, Journal Year: 2024, Volume and Issue: unknown, P. 101031 - 101031

Published: Nov. 1, 2024

Language: Английский

Citations

0