Therapeutic Potential of Nitrogen‐Substituted Oleanolic Acid Derivatives in Neuroinflammatory and Cytokine Pathways: Insights From Cell‐Based and Computational Models DOI
Gurbet Çelik Turgut,

Nicole Pepe,

Yağmur Ceylan Ekiz

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT This study was conducted to investigate the mechanism of potential and anti‐inflammatory properties nitrogen‐substituted oleanolic acid derivatives that can be used treat neuroinflammatory diseases. Nitrogen‐containing have been evaluated for their anti‐neuroinflammatory effects in vitro neuronal monocytic cell lines at nontoxic doses, production cytokines (TNF‐α, IL‐6 IL‐17), inflammatory enzyme induced nitric oxide synthase (iNOS) NF‐κB signalling under LPS‐stimulated conditions, expression genes associated with Alzheimer's disease assessed. In addition, molecular docking dynamics simulation assessments are silico. Key protein markers neurodegenerative diseases, especially neuroinflammation, TAU levels, microglial activation, as well ionised calcium‐binding adaptor protein‐1 (IBA1) were significantly reduced addition derivatives. LPS‐induced luciferase reporter activity iNOS inhibited, approaching levels uninduced controls. The mRNA proinflammatory critical such TNF‐α, NF‐κB, IL‐17, twofold sevenfold. Furthermore, MD analyses revealed interactions TNF‐α proteins. These findings underscore derivatives, particularly compound 16 , candidates further development therapeutic agents diseases chronic inflammation.

Language: Английский

Therapeutic Potential of Nitrogen‐Substituted Oleanolic Acid Derivatives in Neuroinflammatory and Cytokine Pathways: Insights From Cell‐Based and Computational Models DOI
Gurbet Çelik Turgut,

Nicole Pepe,

Yağmur Ceylan Ekiz

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT This study was conducted to investigate the mechanism of potential and anti‐inflammatory properties nitrogen‐substituted oleanolic acid derivatives that can be used treat neuroinflammatory diseases. Nitrogen‐containing have been evaluated for their anti‐neuroinflammatory effects in vitro neuronal monocytic cell lines at nontoxic doses, production cytokines (TNF‐α, IL‐6 IL‐17), inflammatory enzyme induced nitric oxide synthase (iNOS) NF‐κB signalling under LPS‐stimulated conditions, expression genes associated with Alzheimer's disease assessed. In addition, molecular docking dynamics simulation assessments are silico. Key protein markers neurodegenerative diseases, especially neuroinflammation, TAU levels, microglial activation, as well ionised calcium‐binding adaptor protein‐1 (IBA1) were significantly reduced addition derivatives. LPS‐induced luciferase reporter activity iNOS inhibited, approaching levels uninduced controls. The mRNA proinflammatory critical such TNF‐α, NF‐κB, IL‐17, twofold sevenfold. Furthermore, MD analyses revealed interactions TNF‐α proteins. These findings underscore derivatives, particularly compound 16 , candidates further development therapeutic agents diseases chronic inflammation.

Language: Английский

Citations

0