Pharmacological Research, Journal Year: 2022, Volume and Issue: 183, P. 106368 - 106368
Published: July 26, 2022
Language: Английский
Experimental Gerontology, Journal Year: 2024, Volume and Issue: 194, P. 112497 - 112497
Published: June 27, 2024
The gut microbiome plays a crucial role in host health throughout the lifespan by influencing brain function during aging. microbial diversity of human decreases aging process and, as consequence, several mechanisms increase, such oxidative stress, mitochondrial dysfunction, inflammatory response, and dysbiosis. Moreover, evidence indicates that neurodegeneration are closely related; consequently, may serve novel marker elderly. In this narrative study, we investigated how changes composition occur influence to various neuropathological disorders, mild cognitive impairment (MCI), dementia, Alzheimer's disease (AD), Parkinson's (PD); which possible govern relationship between impairment. addition, studies suggest be potential target improve hallmarks promote healthy cognition; therefore, current future therapeutic interventions have been also reviewed.
Language: Английский
Citations
12
Allergology International, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
The gut-brain axis exemplifies the bidirectional connection between intestines and brain, as evidenced by impact of severe stress on gastrointestinal symptoms including abdominal pain diarrhea, conversely, influence discomfort mood. Clinical observations support notion connection, an increased prevalence inflammatory bowel disease (IBD) in patients with depression anxiety, well association changes gut microbiota neurological disorders such multiple sclerosis, Parkinson's disease, stroke Alzheimer's disease. brain communicate via complex mechanisms involving cytokines, immune cells, autonomic nerves, microbiota, which contribute to pathogenesis certain diseases. Two primary pathways mediate information exchange intestinal tract brain: signal transduction through bloodstream factors, bacterial metabolites neural pathways, neurotransmitters cytokines within nervous system interaction nerve cells beyond. In recent years, basic pathophysiology have been gradually elucidated. Beyond interaction, emerging evidence suggests extends other organs, liver lungs, intricate inter-organ communication pathways. An increasing number reports this clinical cross-organ interactions underscore potential for better understanding novel therapeutic strategies targeting inter-organs networks. Further clarification multiorgans premises transformative insights into strategies.
Language: Английский
Citations
1
Pharmacological Research, Journal Year: 2025, Volume and Issue: 214, P. 107694 - 107694
Published: March 10, 2025
Language: Английский
Citations
1
Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9
Published: March 16, 2022
The integrity of intestinal barrier determines homeostasis, which could be affected by various factors, like physical, chemical, and biological stimuli. Therefore, it is considerable interest importance to maintain function. Fortunately, many plant polyphenols, including resveratrol, affect the health barrier. Resveratrol has functions, such as antioxidant, anti-inflammation, anti-tumor, anti-cardiovascular diseases. Accumulating studies have shown that resveratrol affects tight junction, microbial composition, inflammation. In this review, we summarize effects on barriers well potential mechanisms (e.g., inhibiting growth pathogenic bacteria fungi, regulating expression junction proteins, increasing anti-inflammatory T cells while reducing pro-inflammatory cells), highlight applications in ameliorating
Language: Английский
Citations
36
Pharmacological Research, Journal Year: 2022, Volume and Issue: 183, P. 106368 - 106368
Published: July 26, 2022
Language: Английский
Citations
35