Advances in food and nutrition research, Journal Year: 2024, Volume and Issue: unknown, P. 199 - 255
Published: Jan. 1, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: May 20, 2024
Abstract Tumor biomarkers, the substances which are produced by tumors or body’s responses to during tumorigenesis and progression, have been demonstrated possess critical encouraging value in screening early diagnosis, prognosis prediction, recurrence detection, therapeutic efficacy monitoring of cancers. Over past decades, continuous progress has made exploring discovering novel, sensitive, specific, accurate tumor significantly promoted personalized medicine improved outcomes cancer patients, especially advances molecular biology technologies developed for detection biomarkers. Herein, we summarize discovery development including history conventional innovative used biomarker classification biomarkers based on tissue origins, application clinical management. In particular, highlight recent advancements biomarker-based anticancer-targeted therapies emerging as breakthroughs promising strategies. We also discuss limitations challenges that need be addressed provide insights perspectives turn into opportunities this field. Collectively, multiple emphasized review may guidance precision medicine, broaden horizons future research directions, expedite patients according their rather than organs origin.
Language: Английский
Citations
141
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2750 - 2750
Published: Feb. 27, 2024
Inflammation is a key contributor to both the initiation and progression of tumors, it can be triggered by genetic instability within as well lifestyle dietary factors. The inflammatory response plays critical role in epigenetic reprogramming tumor cells, cells that comprise microenvironment. Cells microenvironment acquire phenotype promotes immune evasion, progression, metastasis. We will review mechanisms pathways involved interaction between inflammation, nutrition, limitations current therapies, discuss potential future therapeutic approaches.
Language: Английский
Citations
7
BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Dec. 5, 2024
Abstract Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a universally lethal prognosis despite maximal standard therapies. Here, we present consensus treatment protocol based on metabolic requirements of GBM cells for two major fermentable fuels: glucose and glutamine. Glucose source carbon ATP synthesis growth through glycolysis, while glutamine provides nitrogen, carbon, glutaminolysis. As no can grow without anabolic substrates or energy, simultaneous targeting glycolysis glutaminolysis expected to reduce proliferation if not all cells. Ketogenic therapy (KMT) leverages diet-drug combinations that inhibit glutaminolysis, signaling shifting energy metabolism therapeutic ketosis. The glucose-ketone index (GKI) standardized biomarker assessing biological compliance, ideally via real-time monitoring. KMT aims increase substrate competition normalize microenvironment GKI-adjusted ketogenic diets, calorie restriction, fasting, also glycolytic glutaminolytic flux using specific inhibitors. Non-fermentable fuels, such as ketone bodies, fatty acids, lactate, are comparatively less efficient supporting long-term bioenergetic biosynthetic demands cancer cell proliferation. proposed strategy may be implemented synergistic priming baseline well other tumors driven by regardless their residual mitochondrial function. Suggested best practices provided guide future research oncology, offering shared, evidence-driven framework observational interventional studies.
Language: Английский
Citations
6
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 23, 2024
The Fasting-Mimicking Diet (FMD) is a nutritional strategy that involves significantly reducing calorie intake for specific period to mimic the physiological effects of fasting while still providing body with nutrition. Our study aimed conduct bibliometric explore latest publishing trends and areas intense activity within sphere FMD. We extracted data on FMD publications from Web Science Core Collection (WOSCC) database. analysis was conducted by WOSCC Online Analysis Platform VOSviewer 1.6.16. In total, there were 169 945 authors 342 organizations 25 countries/regions, published in 111 journals. most productive country, organization, author, journal United States, University Southern California, Valter D. Longo, Nutrients, respectively. first high-cited document Ageing Research Reviews authored Mattson et al. this study, they discuss various health benefits including improved metabolic health, weight management, even potential delaying aging processes risk chronic diseases. conclusion, our main research hotspots frontiers cancer, metabolic-related diseases, cognitive improvement. may have some multiple diseases which should be further investigated.
Language: Английский
Citations
5
Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Triple-negative breast cancer (TNBC), lacking expression of estrogen, progesterone, and HER2 receptors, is aggressive lacks targeted treatment options. An RNA editing enzyme, adenosine deaminase acting on 1 (ADAR1), has been shown to play important roles in TNBC tumorigenesis. We posit that ADAR1 functions as a homeostatic factor protecting from internal external pressure, including metabolic stress. tested the hypothesis iron- dependent cell death pathway, ferroptosis, ADAR1-protected vulnerability by showing knockdown sensitizes cells GPX4 inhibitors. By performing single-reaction monitoring-based liquid chromatography coupled mass spectrometry (LC-MS) measure intracellular lipid contents, we showed loss increased abundance polyunsaturated fatty acid phospholipids (PUFA-PL), which peroxidation primary driver ferroptosis. Transcriptomic analyses led discovery proto-oncogene MDM2 contributing remodeling upon loss. A phenotypic drug screen using ferroptosis-focused library was performed identify FDA- approved cobimetinib drug-repurposing candidate synergize with suppress demonstrating regulates fitness through desensitizing aim leverage this inform basic, pre-clinical, clinical studies develop novel therapeutic strategies for TNBC.
Language: Английский
Citations
0
Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 70 - 70
Published: Feb. 7, 2025
In recent years, the exploration of bioactive molecules derived from natural sources has gained interest in several application fields. Among these, macroalgae have garnered significant attention due to their functional properties, which make them interesting therapeutic applications, including cancer treatment. Cancer constitutes a global health burden, and side effects existing treatment modalities underscore necessity for novel models that, line with goal reducing drug treatments, take advantage compounds. This review explores anticancer properties macroalgae, focusing on compounds mechanisms action. The key findings suggest that possess rich array compounds, polysaccharides (e.g., fucoidans alginates), polyphenols phlorotannins), terpenoids, exhibit diverse activities, such as inhibition cell proliferation, angiogenesis, induction apoptosis, modulation immune system. provides an overview current understanding macroalgae’s potential, highlighting most promising While preclinical studies shown results, further research is necessary translate these into effective clinical applications.
Language: Английский
Citations
0
International Journal of Oral and Maxillofacial Surgery, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Experimental Oncology, Journal Year: 2025, Volume and Issue: 46(4), P. 281 - 288
Published: Feb. 20, 2025
In the era of intensive development post-genomic technologies, it is reasonable to review modern strategy for solving problems cancer patients. The current trend new paradigm based on knowledge and possibilities correcting molecular genetic processes principles precision medicine. key role in implementing such an approach belongs innovative among which omics technologies occupy a special place. genesis symbiosis medical-biological cybernetic aimed at processing information databases becomes subject learning functioning complex biological systems. Today, dynamic implementation medicine worth concentrating efforts deep consolidation transdisciplinary approaches that can form algorithm market medical services improving quality life.
Language: Английский
Citations
0
Archives of Cancer Science and Therapy, Journal Year: 2025, Volume and Issue: 9(1), P. 001 - 005
Published: March 3, 2025
The global menace of cancer requires supplementary treatments beyond standard medical approaches for effective intervention. Ketogenic Diet (KD) composed high fats combined with moderate proteins and low carbohydrates has become popular as a metabolic therapy cancer. anti-cancer mechanism KD works through stress induction in cells, reduced insulin IGF-1 signaling pathways, improved mitochondrial function, inflammation, immune regulation. Standard receive enhanced outcomes synergistic action which simultaneously decreases treatment-related side effects. To achieve optimized treatment cancer, ketogenic diet practitioners need to use personalized nutritional planning combination tracking exogenous ketone supplements. It is essential find solutions adherence issues nutrient deficiencies because they determine KD’s effectiveness treatment. fight against needs sustained multipronged clinical research validation establish the proper implementation this method.
Language: Английский
Citations
0