Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 23, 2025
Covalent
organic
frameworks
(COFs)
are
porous
crystals
of
high
potential
in
biomedical
applications.
The
chemical
bonds
within
COF
structures
critical
for
the
overall
therapeutic
performance.
Here,
design
and
synthesis
radioactive
reported
by
introducing
labile
diselenide
into
structure
backbone.
This
bonded
COF,
PorSe-CuPt,
constructed
from
Cu
Pt
ion
porphyrin
units,
is
capable
bond
cleavage
upon
irradiation,
thus
releasing
drug
molecule,
CBL0137,
carried
pores.
Concerted
with
promotion
X-ray
absorption
Pt2⁺
enrichment
oxygen
Cu2⁺,
robust
PANoptosis
achieved
as
well
improved
immunosuppressive
tumor
microenvironment,
thereby
drastically
enhancing
effectiveness
radiotherapy.
integration
backbone
demonstrates
possible
application
clip-off
chemistry
search
highly
responsible
compatible
biomaterials.
Cell Death and Disease,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 4, 2025
Abstract
Doxorubicin,
a
representative
drug
of
the
anthracycline
class,
is
widely
used
in
cancer
treatment.
However,
Doxorubicin-induced
cardiotoxicity
(DIC)
presents
significant
challenge
its
clinical
application.
Mitochondrial
dysfunction
plays
central
role
DIC,
primarily
through
disrupting
mitochondrial
dynamics.
This
study
aimed
to
investigate
impact
Rnd3
(a
Rho
family
GTPase
3)
on
with
focus
Cardiomyocyte-specific
transgenic
mice
(Rnd3-Tg)
and
LSP/LSP
(N-Tg)
were
established
for
vivo
experiments,
adenoviruses
harboring
(Ad-Rnd3)
or
negative
control
(Ad-Control)
injected
myocardium
vitro
experiments.
The
DIC
model
was
using
wild-type,
N-Tg,
Rnd3-Tg
mice,
subsequent
intraperitoneal
injection
Dox
4
weeks.
molecular
mechanism
explored
RNA
sequencing,
immunofluorescence
staining,
co-immunoprecipitation
assay,
protein-protein
docking.
administration
induced
injury
cardiac
dysfunction,
which
ameliorated
by
overexpression.
Further,
augmentation
expression
mitigated
fragmentation
mediated
dynamin-related
protein
1
(Drp1),
thereby
ameliorating
PANoptosis
(pyroptosis,
apoptosis,
necroptosis)
response
Dox.
Mechanically,
interaction
between
Rho-associated
kinase
(Rock1)
may
impede
Rock1-induced
Drp1
phosphorylation
at
Ser616,
thus
inhibiting
fission
dysfunction.
Interestingly,
Rock1
knockdown
nullified
effects
cardiomyocytes
PANoptosis,
as
well
Dox-induced
remodeling
elicited
Rnd3.
enhances
resilience
against
stabilizing
dynamics
reducing
PANoptosis.
Our
findings
suggest
that
Rnd3/Rock1/Drp1
signaling
pathway
represents
novel
target
mitigating
modulating
could
be
strategic
approach
safeguarding
function
patients
undergoing
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(2), P. e0299577 - e0299577
Published: Feb. 27, 2024
Regulated
cell
death
is
a
key
component
of
the
innate
immune
response,
which
provides
first
line
defense
against
infection
and
homeostatic
perturbations.
However,
can
also
drive
pathogenesis.
The
most
well-defined
pathways
be
categorized
as
nonlytic
(apoptosis)
lytic
(pyroptosis,
necroptosis,
PANoptosis).
While
specific
triggers
are
known
to
induce
each
these
pathways,
it
unclear
whether
all
types
express
proteins
required
activate
pathways.
Here,
we
assessed
protein
expression
compared
responses
non-immune
cells
human
mouse
origin
canonical
pyroptotic
(LPS
plus
ATP),
apoptotic
(staurosporine),
necroptotic
(TNF-α
z-VAD),
PANoptotic
(influenza
A
virus
infection)
stimuli.
When
fibroblasts,
both
cells,
macrophages,
expressed
higher
levels
activated
effectors
more
robustly,
including
caspase-1,
gasdermins,
caspase-8,
RIPKs,
in
response
Our
findings
highlight
importance
considering
type
when
examining
mechanisms
regulating
inflammation
death.
Improved
understanding
that
contain
machinery
execute
different
forms
their
link
critical
identify
new
strategies
target
cellular
populations
for
treatment
infectious
diseases,
inflammatory
disorders,
cancer.
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: May 4, 2024
Abstract
Renal
ischemia‒reperfusion
injury
(IRI)
is
one
of
the
main
causes
acute
kidney
(AKI),
which
a
potentially
life-threatening
condition
with
high
mortality
rate.
IRI
complex
process
involving
multiple
underlying
mechanisms
and
pathways
cell
dysfunction.
Additionally,
various
types
death
have
been
linked
to
IRI,
including
necroptosis,
apoptosis,
pyroptosis,
ferroptosis.
These
processes
operate
differently
varying
degrees
in
different
patients,
but
each
plays
role
pathological
conditions
AKI.
Advances
understanding
pathophysiology
will
lead
development
new
therapeutic
approaches
that
hold
promise
for
improving
outcomes
patients
This
review
provides
an
overview
recent
research
on
molecular
IRI-AKI,
focus
regulated
(RCD)
forms
such
as
Overall,
targeting
RCD
shows
potential
approach
treating
IRI-AKI.
Pathogens,
Journal Year:
2025,
Volume and Issue:
14(1), P. 43 - 43
Published: Jan. 8, 2025
PANoptosis
is
a
newly
identified
programmed
cell
death
pathway
that
integrates
characteristics
of
apoptosis,
pyroptosis,
and
necroptosis.
It
plays
dual
role
in
the
host
immune
response
to
bacterial
infections.
On
one
hand,
acts
as
protective
mechanism
by
inducing
infected
cells
eliminate
pathogens
releasing
pro-inflammatory
cytokines
amplify
response.
other
bacteria
can
exploit
evade
defenses.
This
nature
underscores
potential
target
for
developing
novel
therapies
against
review
summarizes
molecular
mechanisms
PANoptosis,
along
with
crosstalk
integration
different
pathways
various
pathogens.
We
also
discuss
roles
infectious
diseases,
including
sepsis,
pulmonary
infections,
intestinal
Elucidating
underlying
how
manipulate
this
offers
critical
insights
into
host-pathogen
interactions.
These
provide
foundation
designing
targeted
antibacterial
strategies,
modulating
inflammation,
advancing
precision
medicine
improve
clinical
outcomes.
European Journal of Pharmacology,
Journal Year:
2025,
Volume and Issue:
995, P. 177414 - 177414
Published: Feb. 20, 2025
Cell
death
occurs
continuously
throughout
individual
development.
By
removing
damaged
or
senescent
cells,
cell
not
only
facilitates
morphogenesis
during
the
developmental
process,
but
also
contributes
to
maintaining
homeostasis
after
birth.
In
addition,
reduces
spread
of
pathogens
by
eliminating
infected
cells.
is
categorized
into
two
main
forms:
necrosis
and
programmed
death.
Programmed
encompasses
several
types,
including
autophagy,
pyroptosis,
apoptosis,
necroptosis,
ferroptosis,
PANoptosis.
Autophagy,
a
mechanism
that
maintains
cellular
equilibrium
via
breakdown
reutilization
proteins
organelles,
implicated
in
regulating
almost
all
forms
pathological
contexts.
Notably,
PANoptosis
are
directly
classified
as
autophagy-mediated
Therefore,
autophagy
presents
therapeutic
approach
for
treating
diseases
such
inflammation
tumors
arise
from
abnormalities
other
This
review
focuses
on
crosstalk
between
modalities,
providing
new
perspectives
clinical
interventions
inflammatory
neoplastic
diseases.
