Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 23, 2025
Covalent
organic
frameworks
(COFs)
are
porous
crystals
of
high
potential
in
biomedical
applications.
The
chemical
bonds
within
COF
structures
critical
for
the
overall
therapeutic
performance.
Here,
design
and
synthesis
radioactive
reported
by
introducing
labile
diselenide
into
structure
backbone.
This
bonded
COF,
PorSe-CuPt,
constructed
from
Cu
Pt
ion
porphyrin
units,
is
capable
bond
cleavage
upon
irradiation,
thus
releasing
drug
molecule,
CBL0137,
carried
pores.
Concerted
with
promotion
X-ray
absorption
Pt2⁺
enrichment
oxygen
Cu2⁺,
robust
PANoptosis
achieved
as
well
improved
immunosuppressive
tumor
microenvironment,
thereby
drastically
enhancing
effectiveness
radiotherapy.
integration
backbone
demonstrates
possible
application
clip-off
chemistry
search
highly
responsible
compatible
biomaterials.
BioChem,
Journal Year:
2025,
Volume and Issue:
5(1), P. 3 - 3
Published: Feb. 11, 2025
The
Ebola
virus
(EBOV),
a
highly
lethal
pathogen
causing
hemorrhagic
fever,
poses
persistent
public
health
threat,
with
devastating
multi-organ
complications
and
high
transmission
potential
through
bodily
fluids.
EBOV’s
pathogenesis
is
marked
by
severe
oxidative
stress
immune
dysregulation,
where
increased
reactive
oxygen
species
(ROS)
levels
foster
cellular
damage,
hinder
defenses,
facilitate
viral
replication.
Through
evasion
suppression
of
responses,
EBOV
affects
both
innate
adaptive
immunity,
activating
pyroptosis,
PANoptosis,
necroptosis,
lymphocyte
apoptosis,
thereby
amplifying
inflammation
disease
severity.
Recent
research
suggests
that
bioactive
molecules,
including
quercetin,
curcumin,
eugenol,
p-anisaldehyde,
may
offer
therapeutic
due
to
their
antioxidant,
anti-inflammatory,
immunomodulatory
effects.
This
review
also
underscores
the
conventional
treatments,
amiodarone,
favipiravir,
remdesivir,
azithromycin,
chloroquine,
nitazoxanide,
as
agents
against
EBOV,
thanks
antiviral
anti-inflammatory
properties,
although
efficacy
varies
across
experimental
models.
These
natural
compounds
could
enhance
resilience
scavenging
ROS,
modulating
inflammation,
mitigating
presenting
promising
adjunctive
strategies
support
therapies.
Arteriosclerosis Thrombosis and Vascular Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 13, 2025
BACKGROUND:
Mechanisms
driving
the
development
of
type
A
aortic
dissection
(TAD)
are
currently
poorly
understood,
and
animal
models
spontaneous
TAD
limited.
In
present
study,
we
developed
a
novel
mouse
model
evaluated
role
GSDMD
(gasdermin
D)
in
development.
METHODS:
TADs
were
created
by
treating
ascending
aorta
adult
C57BL/6J
mice
with
Act
E
(active
elastase)
β-aminopropionitrile.
The
temporal
progress
pathology
was
rigorously
characterized
histological
evaluation
scanning
electron
microscopy,
while
potential
mechanisms
explored
using
bulk
RNA
sequencing
specimens
collected
at
multiple
time
points.
With
this
model,
conducted
additional
experiments
to
investigate
impact
deficiency
on
formation.
RESULTS:
Ascending
aortas
challenged
β-aminopropionitrile
featuring
early
onset
intimomedial
tears
(complete
penetration)
intramural
hematomas,
followed
progressive
medial
loss
dilation.
Ingenuity
pathway
analysis
functional
annotation
differentially
expressed
genes
suggested
that
unique
inflammatory
microenvironment,
rather
than
general
inflammation,
promotes
specifically
recruiting
neutrophils
wall.
At
later
stages,
T
cell–mediated
immune
injury
emerged
as
primary
driver
pathology.
Gsdmd
attenuated
loss,
adventitial
fibrosis,
dilation
TADs.
This
protective
effect
correlated
reduced
cell
death
decreased
T-cell
infiltration
Notably,
cleaved
detected
human
but
absent
healthy
aortas.
CONCLUSIONS:
developed,
targeting
aorta.
generates
microenvironment
activates
specific
subsets,
subsequent
remodeling
Consistently,
mitigates
development,
likely
modulating
responses.
provides
valuable
tool
for
studying
pathogenesis.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 23, 2025
Covalent
organic
frameworks
(COFs)
are
porous
crystals
of
high
potential
in
biomedical
applications.
The
chemical
bonds
within
COF
structures
critical
for
the
overall
therapeutic
performance.
Here,
design
and
synthesis
radioactive
reported
by
introducing
labile
diselenide
into
structure
backbone.
This
bonded
COF,
PorSe-CuPt,
constructed
from
Cu
Pt
ion
porphyrin
units,
is
capable
bond
cleavage
upon
irradiation,
thus
releasing
drug
molecule,
CBL0137,
carried
pores.
Concerted
with
promotion
X-ray
absorption
Pt2⁺
enrichment
oxygen
Cu2⁺,
robust
PANoptosis
achieved
as
well
improved
immunosuppressive
tumor
microenvironment,
thereby
drastically
enhancing
effectiveness
radiotherapy.
integration
backbone
demonstrates
possible
application
clip-off
chemistry
search
highly
responsible
compatible
biomaterials.
