Identification of Oxidative Stress-Related Biomarkers for Pain–Depression Comorbidity Based on Bioinformatics DOI Open Access
Tianyun Zhang,

Menglu Geng,

Xiaoke Li

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8353 - 8353

Published: July 30, 2024

Oxidative stress has been identified as a major factor in the development and progression of pain psychiatric disorders, but underlying biomarkers molecular signaling pathways remain unclear. This study aims to identify oxidative stress-related pain-depression comorbidity. Integrated bioinformatics analyses were applied key genes by comparing comorbidity-related genes. A total 580 differentially expressed 35 (DEOSGs) identified. By using weighted gene co-expression network analysis protein-protein interaction network, 43 5 hub screened out, respectively. DEOSGs enriched biological processes related inflammation. The five genes, RNF24, MGAM, FOS, TKT, deemed potential diagnostic prognostic markers for patients with These may serve valuable targets further research aid early diagnosis, prevention strategies, pharmacotherapy tools this particular patient population.

Language: Английский

Mechanistic insights into connexin-mediated neuroglia crosstalk in neurodegenerative diseases DOI Creative Commons
Simona Denaro, Simona D’Aprile, Nunzio Vicario

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 11, 2025

Neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s (PD), Multiple Sclerosis (MS), and Huntington’s (HD), although distinct in their clinical manifestations, share a common hallmark: disrupted neuroinflammatory environment orchestrated by dysregulation of neuroglial intercellular communication. Neuroglial crosstalk is physiologically ensured extracellular mediators the activity connexins (Cxs), forming proteins gap junctions (Gjs) hemichannels (HCs), which maintain intracellular homeostasis. However, accumulating evidence suggests that Cxs can also act pathological pore conditions, thereby contributing to neurodegenerative phenomena synaptic dysfunction, oxidative stress, ultimately cell death. This review explores mechanistic insights Cxs-mediated communication progression diseases discusses therapeutic potential targeting restore cellular

Language: Английский

Citations

1
Mechanisms and Therapeutic Prospects of Microglia-Astrocyte Interactions in Neuropathic Pain Following Spinal Cord Injury DOI

Yinuo Liu,

Xintong Cai, Bowen Shi

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 62(4), P. 4654 - 4676

Published: Oct. 29, 2024

Language: Английский

Citations

4
Sinoatrial node rod cells transplantation into the injured spinal cord as a novel therapeutic approach to improve proper information transmission DOI
Mohammad Saleh Ranaiy,

Dina Rajabi Zadeh,

Mozhgan Abasi

et al.

Medical Hypotheses, Journal Year: 2025, Volume and Issue: unknown, P. 111608 - 111608

Published: March 1, 2025

Language: Английский

Citations

0
Wnt5a in keratinocytes contributes to complex regional pain syndrome through the activation of NR2B and MMP9 in rats DOI Creative Commons
He Zhu, Bei Wen, Jijun Xu

et al.

Regional Anesthesia & Pain Medicine, Journal Year: 2025, Volume and Issue: unknown, P. rapm - 106139

Published: March 12, 2025

Background Complex regional pain syndrome (CRPS) is a chronic condition characterized by inflammatory features, though the underlying mechanisms remain partly understood. Our study examined whether Wnt5a in skin keratinocytes contributes to CRPS-related hypersensitivity activating downstream N-methyl-D-aspartate receptor subunit 2B (NR2B) and matrix metalloproteinase-9 (MMP9) signaling rats. Methods We developed cell-culture model mimic local inflammation of CRPS rat post-ischemia experienced patients. Mechanical heat thresholds hind paw were measured using an electronic von Frey apparatus radiant device. Western blotting immunofluorescence used examine expressions NR2B MMP9 dorsal root ganglion (DRG), staining connexin 43 (Cx43) protein gene product 9.5 (PGP9.5) conducted explore interaction between nerve fibers skin. Results In cell culture, was expressed contributed cellular injury increasing levels MMP9. The mechanical decreased rats, indicating increased sensitivity. inhibition alleviated these hypersensitivities. High Cx43 PGP9.5 observed epidermis suggesting that may contribute CRPS. Additionally, upregulations DRG further exacerbate pain. Conclusions Skin play essential role pathophysiology increase sensitivity upregulating MMP9, thereby contributing

Language: Английский

Citations

0
Physiology of neuroglia of the central nervous system DOI
Alexei Verkhratsky, Alexey Semyanov

Handbook of clinical neurology, Journal Year: 2025, Volume and Issue: unknown, P. 69 - 91

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Double-Edged Effect of Connexins and Pannexins of Glial Cells in Central and Peripheral Nervous System After Nerve Injury DOI

Yue-Yan Cen,

Xiwu Gao,

Yu‐Heng Feng

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Identification of Oxidative Stress-Related Biomarkers for Pain–Depression Comorbidity Based on Bioinformatics DOI Open Access
Tianyun Zhang,

Menglu Geng,

Xiaoke Li

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8353 - 8353

Published: July 30, 2024

Oxidative stress has been identified as a major factor in the development and progression of pain psychiatric disorders, but underlying biomarkers molecular signaling pathways remain unclear. This study aims to identify oxidative stress-related pain-depression comorbidity. Integrated bioinformatics analyses were applied key genes by comparing comorbidity-related genes. A total 580 differentially expressed 35 (DEOSGs) identified. By using weighted gene co-expression network analysis protein-protein interaction network, 43 5 hub screened out, respectively. DEOSGs enriched biological processes related inflammation. The five genes, RNF24, MGAM, FOS, TKT, deemed potential diagnostic prognostic markers for patients with These may serve valuable targets further research aid early diagnosis, prevention strategies, pharmacotherapy tools this particular patient population.

Language: Английский

Citations

1