TheDrosophilaEstrogen-Related Receptor promotes triglyceride storage within the larval fat body DOI Creative Commons

Tess D. Fasteen,

Melody R. Hernandez,

Robert A. Policastro

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 15, 2024

The Estrogen-Related Receptor (ERR) family of nuclear receptors (NRs) serve key roles in coordinating triglyceride (TAG) accumulation with juvenile growth and development. In both insects mammals, ERR activity promotes TAG storage during the post-embryonic phase, loss-of-function mutations mouse

Language: Английский

Non-canonical hepatic androgen receptor mediates glucagon sensitivity in female mice through the PGC1α/ERRα/mitochondria axis DOI Creative Commons
Jie Chen, Yuanyuan Wu,

Wanyu Hao

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(1), P. 115188 - 115188

Published: Jan. 1, 2025

Language: Английский

Citations

1
The Drosophila Estrogen-Related Receptor promotes triglyceride storage within the larval fat body DOI Creative Commons

Tess D. Fasteen,

Melody R. Hernandez,

Robert A. Policastro

et al.

Journal of Lipid Research, Journal Year: 2025, Volume and Issue: unknown, P. 100815 - 100815

Published: April 1, 2025

Language: Английский

Citations

0
An ERRα-ZEB1 transcriptional signature predicts survival in triple-negative breast cancers DOI

Jingru Shi,

Coralie Poulard, Catherine Cerutti

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Abstract Background. Transcription factors (TFs) act together with co-regulators to modulate the expression of their target genes, which eventually dictates pathophysiological effects. Depending on co-regulator, TFs can exert different activities. The Estrogen Related Receptor α (ERRα) acts as a transcription factor that regulates several phenomena. In particular, interactions PGC-1 co-activators are responsible for metabolic activities ERRα. breast cancers, ERRα exerts tumor-promoting, metabolism-unrelated do not depend PGC1, questioning identity involved in these cancer-related Methods. We used bio-computing methods identify potential co-factors could be cancer progression. Experimental validations were conducted cell lines, using determination mRNA expression, ChIP-qPCR and proximity ligation assays. Results. ZEB1 is proposed major co-factor direct targets triple-negative cancers (TNBC). establish interact bound promoters genes they transcriptionally regulate. Our further analyses show ERRα-ZEB1 downstream signature predict survival TNBC patients. Conclusions. complex actor progression its transcriptional overall

Language: Английский

Citations

0
TheDrosophilaEstrogen-Related Receptor promotes triglyceride storage within the larval fat body DOI Creative Commons

Tess D. Fasteen,

Melody R. Hernandez,

Robert A. Policastro

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 15, 2024

The Estrogen-Related Receptor (ERR) family of nuclear receptors (NRs) serve key roles in coordinating triglyceride (TAG) accumulation with juvenile growth and development. In both insects mammals, ERR activity promotes TAG storage during the post-embryonic phase, loss-of-function mutations mouse

Language: Английский

Citations

0