S-nitrosylation of peroxiredoxin 2 exacerbates hyperuricemia-induced renal injury through regulation of mitochondrial homeostasis
Fei Han,
No information about this author
Ya Dong,
No information about this author
Qiaoyan Liu
No information about this author
et al.
Free Radical Biology and Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Language: Английский
Interplay of ROS, mitochondrial quality, and exercise in aging: potential role of spatially discrete signaling
Siobhan M. Craige,
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Rebecca Mammel,
No information about this author
Niloufar Amiri
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et al.
Redox Biology,
Journal Year:
2024,
Volume and Issue:
77, P. 103371 - 103371
Published: Sept. 24, 2024
Language: Английский
Research progress on the anti‐aging effect of polysaccharides of traditional Chinese medicine: Using Caenorhabditis elegans as an animal model
Jiazi Lin,
No information about this author
Jiamin Yu,
No information about this author
Xiao Wang
No information about this author
et al.
The FASEB Journal,
Journal Year:
2025,
Volume and Issue:
39(6)
Published: March 14, 2025
With
the
growing
elderly
population
and
increasing
incidence
of
various
aging-related
diseases,
scientific
community
is
faced
with
an
urgent
challenge
to
identify
natural
anti-aging
agents.
Traditional
Chinese
medicine
(TCM)
polysaccharides
have
been
proven
good
activities.
This
article
reviews
literature
on
pathways
traditional
applied
Caenorhabditis
elegans
models
in
past
decade.
In
our
study,
we
found
that
45
TCM
from
28
genera
26
families
could
delay
aging
process
C.
elegans.
mainly
by
anti-oxidative
stress,
eliminating
free
radicals,
repairing
DNA
damage,
insulin/insulin-like
growth
factor
signaling
pathway
(IIS
pathway).
addition,
number
prolong
lifespan
reducing
inflammation,
regulating
intestinal
flora,
affecting
immune
cell
function.
this
paper,
was
used
as
animal
model
clarify
polysaccharides,
so
provide
theoretical
guidance
for
future
research
clinical
experiments
effect
polysaccharides.
Language: Английский
Neuronal PRDX-2-Mediated ROS Signaling Regulates Food Digestion via peripheral UPRmt Activation
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Dec. 4, 2024
All
organisms
depend
on
food
digestion
for
survival,
yet
the
brain-gut
signaling
mechanisms
that
regulate
this
process
are
not
fully
understood.
Here,
using
an
established
C.
elegans
model,
we
uncover
a
pathway
in
which
neuronal
ROS
(free
radicals)
signal
intestine
to
suppress
digestion.
Genetic
screening
reveals
reducing
genes
responsible
maintaining
balance
increases
free
radicals
and
decreases
PRDX-2
knockout
olfactory
neurons
(AWC)
elevates
reduces
digestive
capacity,
mediated
by
neuropeptide
NLP-1
activation
of
mitochondrial
unfolded
protein
response
(UPRmt)
intestine.
Additionally,
over-expressing
nlp-1
or
ablating
AWC
both
trigger
UPRmt
inhibit
These
findings
reveal
connection
PRDX-2-mediated
modulates
digestion,
highlighting
critical
role
shutting
down
alleviate
stress
reduce
consumption.
Neuronal
reactive
oxygen
species
(ROS)
triggers
intestinal
response,
halting
cellular
stress.
This
discovery
regulating
intake
via
signaling.
Language: Английский
Peroxiredoxin 2 mediates redox-stimulated adaptations to oxidative phosphorylation induced by contractile activity in human skeletal muscle myotubes
Free Radical Biology and Medicine,
Journal Year:
2024,
Volume and Issue:
227, P. 395 - 406
Published: Dec. 4, 2024
Language: Английский