Incretin hormones and obesity DOI Creative Commons
Constanza Alcaino, Frank Reimann, Fiona M. Gribble

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Abstract The incretin hormones glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) play critical roles in co‐ordinating postprandial metabolism, including modulation of insulin secretion food intake. They are secreted from enteroendocrine cells the intestinal epithelium following ingestion, act at multiple target sites pancreatic islets brain. With recent development agonists targeting GLP‐1 GIP receptors for treatment type 2 diabetes obesity, ongoing new incretin‐based drugs with improved efficacy, there is great interest understanding physiology pharmacology these hormones. image

Language: Английский

Incretin hormones and obesity DOI Creative Commons
Constanza Alcaino, Frank Reimann, Fiona M. Gribble

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Abstract The incretin hormones glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) play critical roles in co‐ordinating postprandial metabolism, including modulation of insulin secretion food intake. They are secreted from enteroendocrine cells the intestinal epithelium following ingestion, act at multiple target sites pancreatic islets brain. With recent development agonists targeting GLP‐1 GIP receptors for treatment type 2 diabetes obesity, ongoing new incretin‐based drugs with improved efficacy, there is great interest understanding physiology pharmacology these hormones. image

Language: Английский

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