Investigation of Anticancer Peptides Derived from Arca Species Using In Silico Analysis DOI Creative Commons

Jixu Wu,

Xiuhua Zhang,

Yuting Jin

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1640 - 1640

Published: April 7, 2025

This study employed an integrated in silico approach to identify and characterize anticancer peptides (ACPs) derived from Arca species. Using a comprehensive bioinformatics pipeline (BIOPEP, ToxinPred, ProtParam, ChemDraw, SwissTargetPrediction, I-TASSER), we screened hydrolyzed bioactive species, identifying seventeen novel peptide candidates. Subsequent vitro validation revealed three (KW, WQIWYK, KGKWQIWYKSL) with significant activity, demonstrating both high biosafety clinical potential. Our findings highlight species proteins as valuable source of therapeutic ACPs establish efficient strategy for rapid discovery peptides. combines computational prediction experimental validation, offering robust framework developing peptide-based therapeutics.

Language: Английский

Investigation of Anticancer Peptides Derived from Arca Species Using In Silico Analysis DOI Creative Commons

Jixu Wu,

Xiuhua Zhang,

Yuting Jin

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1640 - 1640

Published: April 7, 2025

This study employed an integrated in silico approach to identify and characterize anticancer peptides (ACPs) derived from Arca species. Using a comprehensive bioinformatics pipeline (BIOPEP, ToxinPred, ProtParam, ChemDraw, SwissTargetPrediction, I-TASSER), we screened hydrolyzed bioactive species, identifying seventeen novel peptide candidates. Subsequent vitro validation revealed three (KW, WQIWYK, KGKWQIWYKSL) with significant activity, demonstrating both high biosafety clinical potential. Our findings highlight species proteins as valuable source of therapeutic ACPs establish efficient strategy for rapid discovery peptides. combines computational prediction experimental validation, offering robust framework developing peptide-based therapeutics.

Language: Английский

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