Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(3)
Published: Feb. 5, 2025
ABSTRACT
In
this
study,
mononuclear
Ni(II),
Cu(II),
Zn(II),
and
Pd(II)
complexes
of
a
diimine
molecule
(H
2
L)
were
synthesized,
their
structures
elucidated
by
NMR,
FT‐IR,
UV–Vis,
ICP‐OES,
molar
conductivity,
magnetic
susceptibility,
elemental
analysis
techniques.
Stoichiometric
spectroscopic
data
revealed
that
the
have
metal:ligand
ratio
1:1
Schiff
base
coordinates
with
metal(II)
ion
via
nitrogen
atoms
two
imine
groups
oxygen
anions
phenolate
moieties
square
planar
geometry.
The
cytotoxic
activity
properties
ligand
its
metal
screened
in
distinct
cancer
cell
lines:
lung
(A549)
colon
(DLD‐1).
optimized
molecular
geometries,
electrostatic
potential
diagrams,
total
density
states
plots,
frontier
orbitals
H
L
all
at
ground
level
calculated
using
functional
theory.
LANL2DZ
basis
set
containing
effective
core
potentials
for
transition
metals
was
used
quantum
chemical
calculations.
calculations
supported
geometry
ions
complexes.
molecules
to
inhibit
MLK4
kinase
domain
(PDB
ID:
4UYA)
involved
progression
examined
docking
study
best
inhibition
belonged
binding
energy
−10.8
kcal/mol.
stability
L–4UYA
complex
physiological
media
also
confirmed
dynamics
simulation
100
ns.
Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(3)
Published: Feb. 25, 2025
ABSTRACT
Formation
of
a
tridentate
mono‐basic
hydrazone‐quinoxalyl
ligand
was
done
through
condensation
quinoxalyl‐2‐carbohydrazide
with
2‐hydroxy‐1‐naphthaldehyde
(H
2
dip).
The
coordination
capability
H
dip
Ni
(II)
and
V
(IV)
ions
examined
at
molar
ratios
1:1
leading
to
the
synthesis
two
distinct
complexes,
Ni(dip)
VO(dip),
respectively.
chemical
structure
validated
by
many
spectroscopic
techniques.
characterization
included
carbon,
hydrogen,
nitrogen
elemental
analyses
assessments
magnetic
properties
conductivity
behavior.
inhibited
effects
(organic
molecules)
its
chelating
agents
on
constrained
proliferation
three
specific
bacterial/fungal
types,
beside
established
human
cancer
cell
lines,
have
been
evaluated
in
relation
structural
impact
VO(dip)
compared
their
free
research
aimed
determine
nature
influence
metal
chelates
binding
affinity
dip,
Ni(dip),
for
ct‐DNA,
that
is,
calf
thymus
DNA,
depending
viscometric/spectrophotometric
alterations
characters.
Furthermore,
assessment
constants
(13.12,
15.19,
14.88
×
10
7
mol
−1
dm
3
),
Gibbs
energy
(−40.21,
−44.51,
−45.01
kJ
chromism
modes
respectively,
used
examine
interaction
mechanisms
attributing
increased
ct‐DNA
comparison
dip.
antioxidant
potential
within
SOD
(superoxide
dismutase)
DPPH
(2,2‐diphenyl‐1‐picrylhydrazyl)
assays,
reporting
respectable
reactivity.
catalysts
represented
superior
catalytic
oxidative
activity
1,2‐cyclooctene
(unsaturated
hydrocarbons,
CyO)
using
hydrogen
peroxide
homogenous
manner.
At
80°C,
yield
percentage
selective
epoxy‐cyclooctane
(CyOO)
90%
after
h
93%
acetonitrile
(the
best
solvent)
disparity
optimum
actions
these
pertained
differences
electronegativity
Lewis's
acidity,
suggested
mechanistic
pathway.
Applied Organometallic Chemistry,
Journal Year:
2022,
Volume and Issue:
36(5)
Published: March 11, 2022
In
this
study,
Cu
2+
,
Co
Ni
Mn
Zn
Fe
3+
VO
and
UO
2
complexes
derived
from
a
NNO
tridentate
chelating
hydrazone–oxime,
namely,
N
′‐((2E,3Z)‐3‐(hydroxyimino)butan‐2‐ylidene)benzohydrazide
(H
L,1)
were
prepared.
The
elemental,
thermo‐gravimetric,
spectral,
molar
conductivity,
magnetic
measurements
applied
to
elucidate
the
compositions
structures
of
these
new
compounds.
addition
density
functional
theory
(DFT),
studies
employed
acquire
optimal
quantum
chemical
parameters.
analyses
indicate
that
chelator
reacted
as
neutral
or
mononegative
ligand
bonded
metal
ions
via
enolic/ketonic
carbonylic
oxygen,
protonated/deprotonated
oximatic
nitrogen,
azomethine
nitrogen
atoms
adopting
square
planar
distorted
octahedral
geometry.
structural
characterization
hydrazone–oxime
its
was
supported
by
DFT
calculations
according
DFT‐B3LYP
procedure
6‐311+G(d,p)
basis
set.
theoretical
data
revealed
reactivity
is
greater
than
free
L,1),
there
good
agreement
between
practical
data.
thermogravimetric
investigation
shows
break
down
in
two
four
decomposing
steps
temperature
range
extended
50
1000°C.
vitro
antimicrobial
activity
demonstrated
an
increase
upon
chelation,
some
show
enhanced
antibacterial
antifungal
agents.
RSC Advances,
Journal Year:
2022,
Volume and Issue:
12(8), P. 4813 - 4827
Published: Jan. 1, 2022
In
this
study
the
solvent
free
catalytic
oxidation
of
olefins
by
a
new
silica
supported
hydrazone-dioxidotungsten(
vi
)
coordination
compound
is
investigated.
Applied Organometallic Chemistry,
Journal Year:
2022,
Volume and Issue:
37(2)
Published: Oct. 22, 2022
A
dioxidotungsten(VI)
complex,
[WO
2
L(CH
3
OH)]·0.5(CH
OH)
(
1
),
was
prepared
by
the
reaction
of
WCl
6
and
tridentate
ONO‐donor
Schiff
base
ligand
H
L
)
that
obtained
from
2‐hydroxy‐1‐naphthaldehyde
with
4‐aminobenzoic
hydrazide.
Both
were
characterized
various
analyses
including
nuclear
magnetic
resonance
(NMR),
Fourier
transform
infrared
spectroscopy
(FT‐IR)
UV–Vis
spectroscopy,
elemental
analysis.
Single
crystal
X‐ray
analysis
used
to
determine
structure
which
revealed
there
is
a
free
‐NH
group
in
its
structure.
Therefore,
heterogeneous
catalyst
supporting
on
propionyl
chloride‐functionalized
silica
gel.
The
synthesized
supported
Si‐W
diffuse
reflectance
(DRS),
thermogravimetric
(TGA),
FT‐IR,
scanning
electron
microscope
(SEM),
photoelectron
(XPS),
energy‐dispersive
(EDS),
powder
diffraction
(XRD)
analyses.
utilized
oxidation
benzyl
alcohol
derivatives
O
under
reflux
condition
at
air
atmosphere.
effects
concentration
oxidant,
temperature,
nature
solvent
catalytic
performance
resulting
compound
investigated
results
indicated
they
have
considerable
effect
activity
selectivity
.
recovered
several
times
reused
for
reaction.
FT‐IR
SEM,
TGA,
EDS,
XRD
are
no
differences
between
fresh
one.
show
complex
active
stable
benzylic
alcohols
depends
condition.
