Applied Organometallic Chemistry,
Journal Year:
2023,
Volume and Issue:
37(4)
Published: Feb. 7, 2023
In
search
of
novel
medications
that
could
be
effective
in
preventing
and
treating
diabetes,
four
new
[Co(L)(H
2
O)
3
]
(
),
[Ni(L)(H
[Cu(L)(H
O)]
4
)
[Zn(L)(H
5
complexes
were
synthesized
from
4‐Chloro‐2‐(((3‐mercapto‐5‐[pyridin‐4‐yl]‐4
H
‐1,2,4‐triazol‐4‐yl)imino)methyl)phenol
ligand
L
which
is
obtained
by
the
condensation
5‐chlorosalicylaldehyde
with
4‐amino‐5‐(pyridin‐4‐yl)‐4
‐1,2,4‐triazole‐3‐thiol
1:1
ratio.
The
Fourier‐transform
infrared
spectroscopy
(FTIR),
nuclear
magnetic
resonance
(NMR)
1
13
C),
elemental
analyses,
UV–visible,
electron
spin
(ESR),
thermogravimetric
analysis
(TGA),
scanning
microscopy,
energy
dispersive
X‐ray
(EDAX),
diffraction
(XRD)
studies
used
to
successfully
characterize
compounds.
act
a
tridentate
manner
coordinates
metal
ions
through
N
azomethine
,
O
phenolic
S
thiol
functionalities.
On
premise
their
spectral
physico‐analytical
data;
octahedral
geometry
for
complex
while
square
planar
tetrahedral
was
proposed.
Theoretical
calculations
compounds
have
been
performed
using
density
functional
theory
(DFT)/B3LYP
method
parameters
such
as
HOMO‐LUMO
values
MESP
calculated.
vitro
examinations
against
α
‐amylase
‐glucosidase
reveal
promising
results
Nickel
(II)
zinc
found
good
inhibitors.
Molecular
docking
experiments
receptors
1BSI
5ZCC
done
support
observation
considerable
binding
energies
interactions
observed.
Additionally,
100‐ns
molecular
dynamics
simulation
(MDS)
assess
stability
structures
generated
during
silico
research,
it
showed
stable
conformation
pattern
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(23), P. 14840 - 14840
Published: Nov. 27, 2022
Metal
complexes
play
a
crucial
role
in
pharmaceutical
sciences
owing
to
their
wide
and
significant
activities.
Schiff
bases
(SBs)
are
multifaceted
pharmacophores
capable
of
forming
chelating
with
various
metals
different
oxidation
states.
Complexes
SBs
extensively
studied
for
numerous
advantages,
including
low
cost
simple
synthetic
strategies.
They
have
been
reported
possess
variety
biological
activities,
antimicrobial,
anticancer,
antioxidant,
antimalarial,
analgesic,
antiviral,
antipyretic,
antidiabetic
ones.
This
review
summarizes
the
most
recent
studies
on
antimicrobial
antiproliferative
activities
SBs-metal
complexes.
Moreover,
regarding
mononuclear
binuclear
described,
antidiabetic,
antileishmanial,
anti-Alzheimer,
catecholase
Chemistry,
Journal Year:
2022,
Volume and Issue:
4(4), P. 1654 - 1671
Published: Dec. 6, 2022
The
chemistry
of
1,3,4-thiadiazole
is
one
the
most
interesting
scaffolds
for
synthesizing
new
drug
molecules
due
to
their
numerous
pharmacological
activities.
Several
modifications
in
thiadiazole
ring
have
been
made,
proving
it
be
more
potent
and
highly
effective
with
a
less
toxic
scaffold
various
biological
There
are
several
marketed
drugs
containing
structure.
In
this
review
article,
we
tried
compile
newly
synthesized
derivatives
possessing
important
pharmaceutical
significance
since
2014.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(20), P. 11369 - 11380
Published: May 10, 2024
In
keeping
with
our
investigation,
a
simple
and
practical
synthesis
of
novel
heterocyclic
compounds
sulfamoyl
moiety
that
can
be
employed
as
insecticidal
agents
was
reported.
The
compound
2-hydrazinyl-
