ChemistrySelect,
Journal Year:
2023,
Volume and Issue:
8(45)
Published: Dec. 1, 2023
Abstract
Ethyl
2‐amino‐4,5‐diphenylfuran‐3‐carboxylate
(
2
),
a
reactive
synthon,
was
successfully
used
to
synthesize
novel
series
of
furan
and
furo[2,3–
d
]pyrimidinone
analogues
by
interactions
with
the
proper
chemical
reagents.
With
aid
precise
spectroscopic
data
(FT‐IR,
Mass,
1
H‐NMR,
13
C‐NMR
spectra),
structures
products
were
clearly
established.
The
cytotoxic
results
MTT
assay
showed
that
4
(IC
50
=6.1±0.8
&
10.2±2.5
μM),
6
=9.2±2.1
17.8±0.5
11
=7.1±0.5
9.2±1.8
12
=5.4±2.3
9.8±1.7
15
=5.2±2.0
8.8±2.0
18
=4.2±2.4
10.7±1.8
21
=12.8±1.9
18.8±0.9
μM)
had
strong
in
vitro
activities
inhibit
growth
colorectal
carcinoma
(HCT‐116),
prostate
cancer
(PC3)
cell
lines,
respectively.
However,
their
effects
on
normal
lung
fibroblast
(WI‐38)
weak
comparison
5‐fluorouracil
as
positive
control.
On
other
hand,
biological
evaluations
supported
presence
antioxidant
activity
for
,
17
(%
inhibition=89.10,
84.16,
82.09,
88.11,
80.23
%,
respectively)
when
compared
ascorbic
acid
(88.42
%).
It
has
been
proven
most
powerful
compounds
have
superior
protective
influence
DNA
against
bleomycin‐induced
damage.
Expert Opinion on Drug Discovery,
Journal Year:
2024,
Volume and Issue:
19(4), P. 471 - 491
Published: Feb. 19, 2024
Introduction
Tuberculosis
remains
a
significant
concern
in
global
public
health
due
to
its
intricate
biology
and
propensity
for
developing
antibiotic
resistance.
Discovering
new
drugs
is
protracted
expensive
endeavor,
often
spanning
over
decade
incurring
costs
the
billions.
However,
computer-aided
drug
design
(CADD)
has
surfaced
as
nimbler
more
cost-effective
alternative.
CADD
tools
enable
us
decipher
interactions
between
therapeutic
targets
novel
drugs,
making
them
invaluable
quest
tuberculosis
treatments.
Advances in Pharmacological and Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
2024, P. 1 - 14
Published: March 28, 2024
Tuberculosis,
also
known
as
TB,
is
a
widespread
bacterial
infection
that
remains
significant
global
health
issue.
This
study
focuses
on
conducting
thorough
investigation
into
the
synthesis,
evaluation
of
anti-Tb
activity,
molecular
docking,
and
dynamic
simulation
substituted
benzimidazole
derivatives.
A
series
twelve
derivatives
(
Polycyclic aromatic compounds,
Journal Year:
2023,
Volume and Issue:
44(8), P. 5439 - 5459
Published: Oct. 10, 2023
AbstractWe
herein
report
the
synthesis,
spectral
analysis,
DFT
calculations,
in
vitro
and
silico
biological
activities
of
novel
N'-((2-thioxo-1,2-dihydroquinolin-3
yl)methylene)isonicotinohydr-azide
with
its
Cu(II),
Co(II),
Ni(II),
Zn(II)
complexes
have
been
successfully
prepared.
The
ligand
were
characterized
by
analytical,
FT-IR,
1H
NMR,
mass,
UV–visible
spectroscopy,
molar
conductivity,
magnetic
susceptibility
measurements.
Density
Functional
Theory
(DFT)
estimations
for
at
DFT/B3LYP
level
via
6-31
G++
(d,
p)
replicate
structure
geometry.
Furthermore,
molecular
docking
ADME
calculations
also
performed
to
correlate
interpret
experimental
results.
antimicrobial
activity
study
illustrated
enhancement
free
upon
complex
formation,
Cu(II)
(MIC
25
µg
mL−1)
may
be
considered
a
promising
antibacterial
agent,
Ni(II)
as
antifungal
agent.
Also,
synthesized
metal
3.125
showed
anti-TB
against
Mycobacterium
tuberculosis.
In
antioxidant
activity,
excellent
compared
standard
drugs
studies
carried
out
Cytochrome
c
Peroxidase
(PDB
ID:
2X08).Keywords:
AntimicrobialADME-ToxantioxidantDFTisoniazidtransition
complexesquinoline
AcknowledgementsThe
authors
are
grateful
UGC-CPE,
New
Delhi
K
FIST
(VGST,
Government
Karnataka)
providing
grants
form
laboratory
facilities.
thankful
Principal,
Guru
Nanak
First
Grade
College,
Bidar
We
STIC
Cochin
University
SAIF
Punjab
University,
data.
author
BSM
thanks
UGC
funding
(2029-MRP/15-16KABA057/UGC-SWRO).
Director,
Skanda
Life
Sciences
Pvt.
Ltd.,
Sunkadakatte,
Bengaluru
studies.Disclosure
statementNo
potential
conflict
interest
was
reported
authors.
Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi,
Journal Year:
2025,
Volume and Issue:
29(1), P. 44 - 53
Published: April 25, 2025
This
work
aims
to
show
the
relationship
between
photochemical
and
sonophotocehmical
features
of
novel
zinc
phthalocyanine
having
furan-imine
substituent
along
with
synthesis
characterization
complex
(3).
Both
sono-photochemical
techniques
were
applied
in
order
calculate
compare
singlet
oxygen
quantum
yield
(3)
DMSO.
The
was
determined
as
0.12
by
PDT
method
(irradiated
only
light),
while
value
0.78
reached
SPDT
approach
(combination
light
ultrasound).
Considering
efficiency
formation,
it
can
be
said
that
modality
is
a
more
powerful
therapeutic
solution
than
technique
also
may
suitable
sono/photosensitizer
candidate
both
tecniques.
study
will
contribute
field
on
enhancing
generation
using
approach.
