Archiv der Pharmazie,
Journal Year:
2024,
Volume and Issue:
357(10)
Published: July 9, 2024
Globally,
breast
cancer
(BC)
has
the
highest
prevalence
among
malignant
diseases.
BC
is
also
primary
cause
of
death
women.
Notably,
morbidity
been
increasing
continuously
at
an
approximate
growth
rate
2.2%
per
year.
Persistent
a
major
public
health
issue
worldwide.
Consequently,
novel
chemotherapeutic
agents
to
combat
this
lethal
disease
should
be
developed
urgently.
Coumarins
with
interesting
structural
and
mechanistic
variations
exhibit
promising
activity
in
several
forms
BC,
including
BCs
multidrug
resistance.
In
particular,
coumarin
hybrids
composed
one
or
more
anti-BC
pharmacophores
can
target
different
biological
components
cells
simultaneously.
Thus,
are
useful
scaffolds
that
help
improve
efficacy
coumarins,
reduce
side
effects,
pharmacokinetics,
minimize
drug-drug
interactions,
circumvent
drug
This
review,
which
articles
published
from
2020
present
day
have
evaluated,
highlights
landscape
therapeutic
effects
against
cancer.
These
findings
aid
further
investigations
on
antibreast-cancer
therapeutics.
Journal of Heterocyclic Chemistry,
Journal Year:
2024,
Volume and Issue:
61(4), P. 600 - 610
Published: Jan. 29, 2024
Abstract
In
this
study,
we
designed
and
synthesized
several
novel
fused
[1,2,3]triazolo
[4′,5′:3,4]pyrrolo[1,2‐
a
]thieno[2,3‐
d
]pyrimidine
derivatives
using
in
single
[3
+
2]
reaction
cycloaddition
of
3‐(3‐iodoprop‐2‐yn‐1‐yl)thieno[2,3‐d]pyrimidin‐4(3H)‐one
(
4
)
followed
by
C‐C
bond
coupling
with
various
aryl
azides
PEG‐400
medium.
All
the
newly
compounds
were
evaluated
vitro
for
EGFR
kinase
inhibitory
action
as
well
anti‐breast
cancer
activity
against
MDA‐MB‐231
MCF‐7
breast
cell
lines.
When
compared
to
reference
molecule,
erlotinib,
majority
demonstrated
adequate
efficacy.
The
most
promising
compounds,
5g
5i
,
excellent
anticancer
both
lines,
IC
50
values
ranging
from
04.17
±
0.55
8.65
0.89
μ
M,
respectively,
activities
(EGFR:
=
0.467
0.063
0.412
0.081
M).
silico
studies
five
potent
5f
5h
5k
also
carried
out
identify
interactions
receptor
found
that
energy
calculations
covenant
obtained
values.
Results in Chemistry,
Journal Year:
2024,
Volume and Issue:
7, P. 101490 - 101490
Published: Jan. 1, 2024
Epidermal
Growth
Factor
Receptor
is
a
multifunctional
receptor
and
an
important
member
of
tyrosine
kinase
family.
Investigation
on
mechanism
tumour
progression
its
suppression
has
identified
prominent
role
EGFR,
which
was
the
first
amongst
EGFR
various
cellular
functions
but
aberration
results
in
development.
About
half
breast
cancer
cases
overexpresses
making
it
as
appropriate
target
for
discovery
molecular
based
targeted
therapeutics
i.e.,
inhibitors.
This
review
focusses
structural
features,
signaling
pathways
cancer.
In
addition
to
this,
recent
developments
TKIs
targeting
are
discussed
along
with
activity
relationships.
Also,
article
highlights
inhibitors
that
under
clinical
study
patents.
Polymers for Advanced Technologies,
Journal Year:
2024,
Volume and Issue:
35(6)
Published: May 29, 2024
Abstract
Reactant
solubility,
which
dictates
achievable
concentrations,
and
the
stability
of
reaction
intermediates
(excited
states),
solvents
modulate
potential
energy
landscape
influence
rates.
Consequently,
solvent
selection
is
pivotal
in
optimizing
process
productivity,
economic
feasibility,
environmental
footprint.
At
present,
organic
synthesis
pivots
around
idea
sustainability.
In
particular,
PEG‐400,
a
popular
phase
transfer
catalyst,
considered
greener
as
it
can
be
reused
several
times
without
significant
loss
its
catalytic
activity,
checks
box
regarding
This
review
highlights
emerging
Polyethylene
Glycol
400
(PEG‐400)
dual‐threat
agent
sustainable
synthesis.
We
explore
efficacy
promoting
various
reactions
under
mild
conditions
often
eliminating
need
for
traditional
metal
catalysts.
Additionally,
PEG‐400's
role
green
addressed,
emphasizing
biodegradability,
low
toxicity,
ability
to
facilitate
hazardous
Volatile
Organic
Compounds
(VOCs).
The
examines
recent
research
on
PEG‐400
mediated
reactions,
showcasing
effectiveness
diverse
transformations,
thus
exploring
PEG
facilitator
heterocycle
both
multicomponent
stepwise
approaches.
It
identifies
exciting
directions
that
promise
expand
boundaries
polymer‐based
heterocyclic
chemistry.
Archiv der Pharmazie,
Journal Year:
2025,
Volume and Issue:
358(3)
Published: March 1, 2025
Abstract
Cancer,
with
its
steadily
increasing
morbidity
and
mortality,
will
continue
to
pose
a
threat
humanity
over
an
extended
period.
Chemotherapeutics
play
indispensable
role
in
cancer
treatment,
hundreds
of
drugs
have
been
approved
for
this
purpose.
Nevertheless,
the
fight
against
remains
formidable
challenge.
This
is
mainly
due
emergence
multidrug
resistance
severe
side
effects
associated
currently
available
anticancer
drugs.
Consequently,
there
urgent
imperative
explore
novel
chemotherapeutic
agents.
1,2,3‐Triazoles
belong
one
most
privileged
classes
nitrogen‐containing
five‐membered
heterocycles
are
regarded
as
prominent
sources
development
innovative
chemotherapeutics.
1,2,3‐Triazole
hybrids,
which
possess
multitargeted
mechanisms
action
within
progression
pathway,
hold
potential
overcome
mitigate
effects.
Furthermore,
several
1,2,3‐triazole
hybrids
already
therapy
or
under
clinical
evaluation.
clearly
demonstrates
that
valuable
scaffolds
treatment
eradication
cancer.
review
aims
provide
insights
into
therapeutic
along
their
action,
crucial
aspects
design,
structure–activity
relationships
(SARs).
It
encompasses
articles
published
from
2021
onward.
